Article Archive

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Transabdominal ultrasonography for small-bowel lesions in Crohn's disease: a prospective comparison with balloon-assisted enteroscopy.
Intestinal research

Transabdominal ultrasonography for small-bowel lesions in Crohn's disease: a prospective comparison with balloon-assisted enteroscopy.

Noninvasive TUS can help detect small-bowel inflammation and stenosis in Crohn's disease with high specificity, potentially reducing the need for immediate invasive testing. However, its sensitivity varies by small-bowel...

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Diagnostic accuracy of magnetic resonance enterography and intestinal ultrasound for treatment response assessment in Crohn's disease (MANTRA): protocol for a multicentre, non-randomised, multiple-arm, prospective cohort comparison study.
BMJ open

Diagnostic accuracy of magnetic resonance enterography and intestinal ultrasound for treatment response assessment in Crohn's disease (MANTRA): protocol for a multicentre, non-randomised, multiple-arm, prospective cohort comparison study.

This study could clarify which imaging test—MRE or IUS—is more accurate or appropriate for monitoring treatment response in Crohn's disease, potentially standardising follow-up and informing patient and clinician...

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The Impact of Fistulizing Disease, Treatment Modalities, and Clinical Activity on Health-Related Quality of Life in Crohn's Disease.
Digestive diseases and sciences

The Impact of Fistulizing Disease, Treatment Modalities, and Clinical Activity on Health-Related Quality of Life in Crohn's Disease.

The study indicates that active inflammation—measured by CDAI and PDAI—drives poorer quality of life in Crohn's disease more than the mere presence of fistulas. That shifts focus toward controlling inflammation to...

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"The role of red cell distribution width in inflammatory bowel disease evaluation: a comprehensive systematic review and meta-analysis".
BMC gastroenterology

"The role of red cell distribution width in inflammatory bowel disease evaluation: a comprehensive systematic review and meta-analysis".

The review suggests RDW, an inexpensive and widely available blood test parameter, is higher in IBD and correlates with disease activity—meaning it might help clinicians monitor disease alongside other tests.

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Long-term efficacy and safety of vedolizumab compared with infliximab in biologic-naive ulcerative colitis: a systematic review and meta-analysis
Intestinal Research

Long-term efficacy and safety of vedolizumab compared with infliximab in biologic-naive ulcerative colitis: a systematic review and meta-analysis

This meta-analysis pooled long‑term comparative data suggesting vedolizumab may have advantages over infliximab for treatment persistence, 12‑month remission, and safety in biologic‑naive ulcerative colitis — information...

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Beyond Colectomy—Interpreting Long‐Term Disease Burden and Clinical Trajectories in Moderate‐to‐Severe Ulcerative Colitis
Journal of Gastroenterology and Hepatology

Beyond Colectomy—Interpreting Long‐Term Disease Burden and Clinical Trajectories in Moderate‐to‐Severe Ulcerative Colitis

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Colectomy. The original article is from Journal of Gastroenterology and...

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Creatine Preserves Colonic Epithelial and Vascular Barrier Integrity and Epithelial Scutoid Geometry Across Active and Remission Phases of Chronic Colitis with Sex-Specific Effects
MDPI AG

Creatine Preserves Colonic Epithelial and Vascular Barrier Integrity and Epithelial Scutoid Geometry Across Active and Remission Phases of Chronic Colitis with Sex-Specific Effects

If findings translate to humans, creatine might help protect the gut lining and blood vessels during flare and remission, potentially supporting recovery of gut barrier function in ulcerative colitis.

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Microbial metabolite hyodeoxycholic acid induces macrophage immunometabolic reprogramming and alleviates ulcerative colitis.
Cell reports

Microbial metabolite hyodeoxycholic acid induces macrophage immunometabolic reprogramming and alleviates ulcerative colitis.

The work links a missing bacterial metabolite (HDCA) to macrophage metabolism and reduced intestinal inflammation in experimental models, highlighting a potential microbiome-derived pathway that could be targeted for...

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Chemical Profiling of Commiphora gileadensis, Salsola incanescens, and Savignya parviflora and Their Protective Effects in an Acute Rat Model of Ulcerative Colitis
Pharmaceuticals

Chemical Profiling of Commiphora gileadensis, Salsola incanescens, and Savignya parviflora and Their Protective Effects in an Acute Rat Model of Ulcerative Colitis

This study identifies plant extracts—especially Commiphora gileadensis—that reduced inflammation and tissue injury in cell assays and an acute rat model of ulcerative colitis, suggesting new leads for future IBD drug...

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Transient receptor potential vanilloid channels in inflammatory bowel diseases: linking inflammation, angiogenesis, and oxidative stress.
Inflammopharmacology

Transient receptor potential vanilloid channels in inflammatory bowel diseases: linking inflammation, angiogenesis, and oxidative stress.

TRPV channels are proposed as integrative mediators of inflammation, angiogenesis, and oxidative stress in IBD, suggesting new mechanistic targets that could eventually yield novel therapies for Crohn's disease and...

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Synergistic Effect of VSL#3TM and Vedolizumab for Ulcerative colitis: Preliminary Evidence from a Real-world Single-Arm study

The report suggests a probiotic (VSL#3TM) added to vedolizumab may speed or increase early response in ulcerative colitis, which could interest patients and clinicians seeking ways to improve biologic induction outcomes....

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How Complex Dietary Fibers Can Be Used to Shape the Human Gut Microbiome Toward Reduced Inflammatory Potential: A Pilot Study
Molecules

How Complex Dietary Fibers Can Be Used to Shape the Human Gut Microbiome Toward Reduced Inflammatory Potential: A Pilot Study

The study suggests that combining different fermentable fibers may steer the gut microbiome toward more butyrate-producing bacteria and away from pro-inflammatory lineages—changes that could be relevant to IBD-related...

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Switching from sulphasalazine or oral 5-aminosalicylic acid to another oral 5-aminosalicylic acid drug in the maintenance of remission in ulcerative colitis
Cochrane Database of Systematic Reviews

Switching from sulphasalazine or oral 5-aminosalicylic acid to another oral 5-aminosalicylic acid drug in the maintenance of remission in ulcerative colitis

Based on the title and source metadata, this appears to be a systematic review or meta analysis related to Ulcerative colitis and Research and clinical trials. The original article is from Cochrane Database of Systematic...

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Letter to the Editor: 5-Year Outcomes and Disease Trajectories in Moderate-to-Severe Ulcerative Colitis: A Korean Multicenter Inception Cohort.
Journal of gastroenterology and hepatology

Letter to the Editor: 5-Year Outcomes and Disease Trajectories in Moderate-to-Severe Ulcerative Colitis: A Korean Multicenter Inception Cohort.

Cure8 found this source from Journal of gastroenterology and hepatology, but the page could not be read reliably yet. It is tagged for Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials....

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Environmental pollutants and the rising burden of inflammatory bowel disease in East Asia: a narrative review.
Intestinal research

Environmental pollutants and the rising burden of inflammatory bowel disease in East Asia: a narrative review.

Environmental pollutants that are increasing in many East Asian settings — air pollution, heavy metals, pesticides, and microplastics — may contribute to rising IBD rates by affecting the gut microbiome and intestinal...

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Norcantharidin Ameliorates Experimental Ulcerative Colitis Through Epigenetic and Metabolic Reprogramming Involving IL-6/DNMT1/SOCS3 and AMPK/SIRT1/FOXO3a-Nrf2 Signaling
International Journal of Molecular Sciences

Norcantharidin Ameliorates Experimental Ulcerative Colitis Through Epigenetic and Metabolic Reprogramming Involving IL-6/DNMT1/SOCS3 and AMPK/SIRT1/FOXO3a-Nrf2 Signaling

The study identifies a candidate compound (NCTD) that reduced inflammation and tissue damage in a rat ulcerative colitis model and implicates specific inflammatory, epigenetic, metabolic, and antioxidant pathways —...

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Anti-Inflammatory Components of Artemisia scoparia Alleviate Ulcerative Colitis: An Integrated Study Combining UPLC-Q-Exactive Orbitrap MS/MS, Network Pharmacology, Molecular Docking, and In Vivo/In Vitro Validation
Foods

Anti-Inflammatory Components of Artemisia scoparia Alleviate Ulcerative Colitis: An Integrated Study Combining UPLC-Q-Exactive Orbitrap MS/MS, Network Pharmacology, Molecular Docking, and In Vivo/In Vitro Validation

The study identifies specific anti-inflammatory compounds in Artemisia scoparia and shows they reduce inflammation in cell and mouse models of ulcerative colitis, suggesting potential new leads for drug or...

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Letter to the Editor: 5‐Year Outcomes and Disease Trajectories in Moderate‐to‐Severe Ulcerative Colitis: A Korean Multicenter Inception Cohort
Journal of Gastroenterology and Hepatology

Letter to the Editor: 5‐Year Outcomes and Disease Trajectories in Moderate‐to‐Severe Ulcerative Colitis: A Korean Multicenter Inception Cohort

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of...

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Environment shapes gut microbiome and determines susceptibility to DSS-colitis in Adamdec1-/- mice
Frontiers in Immunology

Environment shapes gut microbiome and determines susceptibility to DSS-colitis in Adamdec1-/- mice

The paper highlights how the gut microbiome and environment can strongly influence colitis severity in genetically susceptible mice, illustrating a gene–environment–microbiome axis that may help explain heterogeneity in...

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Physiologically Based Pharmacokinetic Modeling of Vedolizumab in Healthy Adults and Patients with Inflammatory Bowel Disease
Clinical Pharmacokinetics

Physiologically Based Pharmacokinetic Modeling of Vedolizumab in Healthy Adults and Patients with Inflammatory Bowel Disease

Vedolizumab blood levels can vary with disease activity; a model that links intestinal α4β7 expression to drug exposure helps explain why some patients have lower drug levels and may need different dosing. This could...

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UNRAVELLING A HIDDEN SUBTYPE: MULTIOMICS REVEAL PSORIASIS-LIKE SIGNATURE WITH SURGICAL RELEVANCE IN A SUBSET OF PERIANAL FISTULIZING CROHN'S DISEASE

This study suggests there are distinct molecular subtypes of perianal fistulizing Crohn’s disease, and some subtypes may be more likely to benefit from surgical repair while others have higher inflammatory burden and...

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Optimised mesalazine therapy reduces ulcerative colitis recurrence across the mild-to-moderate disease spectrum: the IMPACT study
Frontiers in Gastroenterology

Optimised mesalazine therapy reduces ulcerative colitis recurrence across the mild-to-moderate disease spectrum: the IMPACT study

Higher, optimised doses of prolonged-release mesalazine were linked with fewer clinical recurrences over 12 months in adults with mild-to-moderate UC, which could influence treatment decisions about mesalazine dose and...

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Quince Gel Attenuates Experimental Ulcerative Colitis Through Antioxidant, Anti-Inflammatory and Mucosal Repair Mechanisms: Integrated Histopathological, Bioinformatic and Molecular Docking Analyses
Pharmaceuticals

Quince Gel Attenuates Experimental Ulcerative Colitis Through Antioxidant, Anti-Inflammatory and Mucosal Repair Mechanisms: Integrated Histopathological, Bioinformatic and Molecular Docking Analyses

This preclinical study suggests quince gel reduced inflammation, oxidative stress, and tissue injury in a rat model of ulcerative colitis and identifies quercetin as a likely active component. Findings point to possible...

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Preclinical and limited clinical evidence for metformin in ulcerative colitis: a systematic review and meta-analysis
Naunyn-Schmiedeberg's Archives of Pharmacology

Preclinical and limited clinical evidence for metformin in ulcerative colitis: a systematic review and meta-analysis

Metformin is a common, inexpensive drug with possible anti-inflammatory effects; this review compiles preclinical and early clinical data suggesting it might influence ulcerative colitis biology. Readers may want to know...

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Ziwu-Liuzhu-guided combined external therapy promotes wound healing in postoperative perianal fistulizing Crohn’s disease
World Journal of Gastrointestinal Surgery

Ziwu-Liuzhu-guided combined external therapy promotes wound healing in postoperative perianal fistulizing Crohn’s disease

Perianal fistulizing Crohn’s disease causes delayed healing and high recurrence after surgery. This study suggests a specific time-guided external traditional therapy may speed wound healing, reduce inflammation, and...

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Benzoylpaeoniflorin regulates macrophage polarization via the RNF31-DPEP2 axis to ameliorate intestinal mucosal barrier damage in ulcerative colitis.
International immunopharmacology

Benzoylpaeoniflorin regulates macrophage polarization via the RNF31-DPEP2 axis to ameliorate intestinal mucosal barrier damage in ulcerative colitis.

This preclinical study identifies benzoylpaeoniflorin (BPF) as a compound that improved experimental colitis in mice by changing macrophage polarization via the RNF31–DPEP2–NF-κB pathway. It highlights a possible...

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Phlegmon, Not Abscess: Multimodal Transperineal Ultrasound Altering Surgical Approach in a Case of Complex Perianal Fistulizing Crohn's Disease
Journal of Clinical Ultrasound

Phlegmon, Not Abscess: Multimodal Transperineal Ultrasound Altering Surgical Approach in a Case of Complex Perianal Fistulizing Crohn's Disease

For people with perianal Crohn’s disease, better bedside imaging that distinguishes phlegmon from abscess can change surgery plans and may avoid unnecessary wide drainage procedures.

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ĐẶC ĐIỂM RỐI LOẠN TRẦM CẢM Ở NGƯỜI BỆNH CROHN ĐIỀU TRỊ TẠI TRUNG TÂM TIÊU HÓA- GAN MẬT BỆNH VIỆN BẠCH MAI
Tạp chí Y học Cộng đồng

ĐẶC ĐIỂM RỐI LOẠN TRẦM CẢM Ở NGƯỜI BỆNH CROHN ĐIỀU TRỊ TẠI TRUNG TÂM TIÊU HÓA- GAN MẬT BỆNH VIỆN BẠCH MAI

Depression is common in people with Crohn’s disease and can affect quality of life and ability to manage IBD. Knowing prevalence and common symptoms locally helps clinicians and patients recognize and seek appropriate...

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The hostile abdomen dilemma: the safety of primary anastomosis in the presence of an intraoperative abscess in Crohn disease.
Inflammatory bowel diseases

The hostile abdomen dilemma: the safety of primary anastomosis in the presence of an intraoperative abscess in Crohn disease.

If surgeons can safely perform a primary bowel reconnection when they encounter an intra-abdominal abscess during Crohn surgery, some patients may avoid a temporary stoma and its associated morbidity.

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