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Crohn's disease

Crohn's disease news across medications, symptoms, tests, procedures, complications, research, access, and daily life.

Page 11 of 53 · 2515 articles

Decoding Personalized Nutritional, Microbiome and Host Patterns Impacting Clinical and Prognostic Features in Crohn's Disease
ClinicalTrials.gov

Decoding Personalized Nutritional, Microbiome and Host Patterns Impacting Clinical and Prognostic Features in Crohn's Disease

Understanding how individual diet and microbiome patterns relate to disease activity could help create personalized dietary approaches for children with Crohn's disease and improve monitoring using home fecal...

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Long-term clinical outcomes of stem cell-based interventions in Crohn's-related perianal fistula: A systematic review and meta-analysis.
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

Long-term clinical outcomes of stem cell-based interventions in Crohn's-related perianal fistula: A systematic review and meta-analysis.

Perianal fistulas in Crohn’s disease are often hard to treat; this review suggests stem cell therapies can produce durable closure for many patients and appear safe over 1–4 years of follow-up.

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B.C. couple gives $10 million gift for digestive health centre at St. Paul's Hospital - Vancouver Sun
vancouversun.com

B.C. couple gives $10 million gift for digestive health centre at St. Paul's Hospital - Vancouver Sun

A dedicated Digestive Health Centre could make it easier for people with IBD (including children and teens) to access coordinated care—fewer separate visits and more centralized specialist services in one location.

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Brief report: Effectiveness and safety of recombinant zoster vaccine in inflammatory bowel disease patients aged 18 years and older: A matched cohort and self-controlled case series study.
Human vaccines & immunotherapeutics

Brief report: Effectiveness and safety of recombinant zoster vaccine in inflammatory bowel disease patients aged 18 years and older: A matched cohort and self-controlled case series study.

People with IBD are at higher risk for shingles; this study suggests the recombinant zoster vaccine reduces that risk and did not increase short-term IBD flares in the populations studied. That could inform vaccine...

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Patient Perspectives on Climate Change and Sustainable Healthcare Practices: A Cross-Sectional Survey Study in Patients with Inflammatory Bowel Disease.
Journal of gastrointestinal and liver diseases : JGLD

Patient Perspectives on Climate Change and Sustainable Healthcare Practices: A Cross-Sectional Survey Study in Patients with Inflammatory Bowel Disease.

Many IBD patients in this survey expressed concern about climate change and willingness to support sustainable healthcare options—information that could influence how care pathways, device reuse, or treatment-choice...

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Evaluation of a Mental Health Care App-Based Fatigue Management Program for Patients With Inflammatory Bowel Disease in Remission: Protocol for a Randomized Controlled Trial.
JMIR research protocols

Evaluation of a Mental Health Care App-Based Fatigue Management Program for Patients With Inflammatory Bowel Disease in Remission: Protocol for a Randomized Controlled Trial.

Fatigue greatly affects quality of life for people with IBD even in remission; if effective and scalable, a mobile CBT program could offer accessible symptom support. The trial will also examine engagement factors...

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A Comprehensive Self-Management Intervention for Individuals With Inflammatory Bowel Disease
ClinicalTrials.gov

A Comprehensive Self-Management Intervention for Individuals With Inflammatory Bowel Disease

Self-management programs that teach cognitive behavioral strategies, symptom tracking, relaxation, sleep and diet skills could help people with IBD manage symptoms and day-to-day quality of life without relying solely on...

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Palisade Bio to Present Clinical and Translational Data for PALI-2108 in Ulcerative Colitis and Crohn’s Disease at UEG Week 2026
finance.yahoo.com

Palisade Bio to Present Clinical and Translational Data for PALI-2108 in Ulcerative Colitis and Crohn’s Disease at UEG Week 2026

This press release announces upcoming presentations of early clinical and biomarker data for PALI-2108, a gut‑targeted oral PDE4 prodrug being developed for UC and Crohn’s disease. Patients and clinicians may see new...

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Functional Gut Microbiota Alterations in Patients with Inflammatory Bowel Disease Receiving Long-Term Biologic Therapy: A Pilot Comparative Study.
Journal of clinical medicine

Functional Gut Microbiota Alterations in Patients with Inflammatory Bowel Disease Receiving Long-Term Biologic Therapy: A Pilot Comparative Study.

This study suggests that even when people with IBD are in clinical and biological remission on long-term biologic therapy, their gut microbiome composition and inferred functions can still differ from laboratory...

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Medical Therapies Beyond Infliximab for Perianal Fistulizing Crohn's Disease: Current Evidence and Future Perspectives.
Journal of clinical medicine

Medical Therapies Beyond Infliximab for Perianal Fistulizing Crohn's Disease: Current Evidence and Future Perspectives.

Perianal fistulas are a common, hard-to-heal complication of Crohn's disease. This review collects current options beyond infliximab and explains where evidence is stronger or still emerging, which can help patients and...

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Persistence, Safety and Pharmacokinetics of Vedolizumab After Switching to the Subcutaneous Route in a Prospective French National Cohort Study
Alimentary Pharmacology & Therapeutics

Persistence, Safety and Pharmacokinetics of Vedolizumab After Switching to the Subcutaneous Route in a Prospective French National Cohort Study

If you or your clinician are considering switching from IV to subcutaneous vedolizumab, this multicentre cohort suggests most patients (about 84%) remain on the subcutaneous formulation at one year. The switch appears...

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Beyond inflammation control: Rethinking fatigue as a multidimensional target in Crohn’s disease management
World Journal of Gastroenterology

Beyond inflammation control: Rethinking fatigue as a multidimensional target in Crohn’s disease management

Fatigue markedly affects quality of life for people with Crohn’s and often remains after inflammation is controlled. Recognizing multiple drivers — psychological distress and immune/hematologic signals — could change how...

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Association of prealbumin with risk of abdominal surgery and endoscopic recurrence in Crohn’s disease: A machine learning study
World Journal of Gastroenterology

Association of prealbumin with risk of abdominal surgery and endoscopic recurrence in Crohn’s disease: A machine learning study

If validated, prealbumin — a routine blood protein test reflecting nutrition and inflammation — could help predict who with Crohn’s disease is more likely to need abdominal surgery or to have endoscopic recurrence after...

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Improving Endoscopic Scoring Accuracy in Pediatric Inflammatory Bowel Disease: Impact of a Focused Training Intervention
Endoscopy International Open

Improving Endoscopic Scoring Accuracy in Pediatric Inflammatory Bowel Disease: Impact of a Focused Training Intervention

Consistent, accurate endoscopic scoring matters for treatment decisions and trial outcomes in pediatric IBD. If focused training meaningfully improves scoring—especially for SES‑CD—it could reduce variability in clinical...

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Genetically predicted circulating polyunsaturated fatty acids and Crohn's disease susceptibility: A two-sample mendelian randomization study.
Medicine

Genetically predicted circulating polyunsaturated fatty acids and Crohn's disease susceptibility: A two-sample mendelian randomization study.

If confirmed, genetic evidence that higher omega-3 levels or a lower omega-6/omega-3 ratio relate to lower Crohn’s disease risk could point to biological pathways worth studying and might guide research into prevention...

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Bidirectional causal associations between Sjögren syndrome and gastrointestinal disorders: A two-sample Mendelian randomization study.
Medicine

Bidirectional causal associations between Sjögren syndrome and gastrointestinal disorders: A two-sample Mendelian randomization study.

People with Sjögren syndrome or clinicians caring for them may be interested because genetic data suggest Sjögren syndrome could modestly raise gastric ulcer risk and — unexpectedly — associate with lower IBS risk, while...

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Inflammatory Bowel Disease: From Multifactorial and Metabolic Pathogenesis to Systemic Disease and Precision Medicine
Metabolites

Inflammatory Bowel Disease: From Multifactorial and Metabolic Pathogenesis to Systemic Disease and Precision Medicine

This review reframes IBD as a systemic disease influenced by gut microbes, metabolism, and immune interactions — which matters because it points toward better ways to stratify patients, monitor disease, and personalize...

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Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease
ClinicalTrials.gov

Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease

This trial tests several targeted therapies (including risankizumab) alone and in combination for adults with moderate to severe Crohn's disease, aiming to measure endoscopic remission and safety. Positive findings could...

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Proanthocyanidins in immune-mediated inflammatory diseases: molecular mechanisms and therapeutic potential
Frontiers in Pharmacology

Proanthocyanidins in immune-mediated inflammatory diseases: molecular mechanisms and therapeutic potential

People with IBD may be interested because the review highlights a class of dietary polyphenols that could influence inflammation and immune pathways involved in Crohn’s disease and ulcerative colitis. It summarizes...

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Single-cell analysis of chromatin accessibility in the human intestine identifies regulatory programs and clarifies genetic associations in Crohn’s disease
Nature Genetics

Single-cell analysis of chromatin accessibility in the human intestine identifies regulatory programs and clarifies genetic associations in Crohn’s disease

Based on the title and source metadata, this appears to be a basic science related to Crohn's disease, Inflammatory bowel disease, and Research and clinical trials. The original article is from Nature Genetics.

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