Condition

Inflammatory bowel disease

Broader IBD news covering Crohn's disease, ulcerative colitis, research, treatments, monitoring, and patient care.

Page 63 of 88 · 4189 articles

Efficacy and Safety of Guselkumab in Patients With Moderate-to-Severe Ulcerative Colitis:A Real-World Prospective Cohort Study.
ClinicalTrials.gov

Efficacy and Safety of Guselkumab in Patients With Moderate-to-Severe Ulcerative Colitis:A Real-World Prospective Cohort Study.

This trial is testing guselkumab (an IL‑23 inhibitor) in a real‑world UC cohort and will measure endoscopic and histologic remission at 48 weeks — outcomes that matter to people managing moderate‑to‑severe ulcerative...

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Hiding in Plain Sight: A Case of Intestinal Tuberculosis Masquerading as Benign Lower GI Bleeding.
Case reports in gastrointestinal medicine

Hiding in Plain Sight: A Case of Intestinal Tuberculosis Masquerading as Benign Lower GI Bleeding.

This report shows intestinal tuberculosis can present like inflammatory bowel disease with lower GI bleeding, leading to diagnostic delay; correct identification allowed targeted anti-TB and HIV therapy and clinical...

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Shikonin Alleviated Epithelial Responses in a Lipopolysaccharide/Tumor Necrosis Factor Alpha-induced Ulcerative Colitis-like Condition in Caco-2/HT-29 Co-cultured Cells by Modulating the MAPK/NLRP3/Nuclear Factor Kappa B Pathways.
Journal of physiological investigation

Shikonin Alleviated Epithelial Responses in a Lipopolysaccharide/Tumor Necrosis Factor Alpha-induced Ulcerative Colitis-like Condition in Caco-2/HT-29 Co-cultured Cells by Modulating the MAPK/NLRP3/Nuclear Factor Kappa B Pathways.

Cure8 found this source from Journal of physiological investigation, but the page could not be read reliably yet. It is tagged for Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. Open...

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EXPRESS: Inflammatory bowel disease and cardiovascular risk: A meta-analysis.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research

EXPRESS: Inflammatory bowel disease and cardiovascular risk: A meta-analysis.

This meta-analysis suggests people with IBD face higher risks of major cardiovascular events (heart attack, ischemic heart disease, ischemic stroke), which may matter for monitoring and preventive care. Higher risk...

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Effects of cuproptosis and its application in inflammatory bowel disease (Review).
International journal of molecular medicine

Effects of cuproptosis and its application in inflammatory bowel disease (Review).

Researchers report links between copper-driven cell death pathways and IBD biology; identifying cuproptosis-related biomarkers or drugs could open new diagnostic or therapeutic avenues for people with Crohn's disease or...

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Dietary, lifestyle, and environmental factors associated with ulcerative colitis: a systematic review and meta-analysis of observational studies
Frontiers in Nutrition

Dietary, lifestyle, and environmental factors associated with ulcerative colitis: a systematic review and meta-analysis of observational studies

This review summarizes many observational studies to identify dietary and environmental factors that may influence the risk of developing ulcerative colitis, which could help guide future research and prevention efforts...

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Protective effects and possible mechanisms of matrine-type alkaloids (matrine and oxymatrine) in animal models of ulcerative colitis: a preclinical systematic review and meta-analysis
Frontiers in Pharmacology

Protective effects and possible mechanisms of matrine-type alkaloids (matrine and oxymatrine) in animal models of ulcerative colitis: a preclinical systematic review and meta-analysis

The review suggests matrine and oxymatrine reduce inflammation and oxidative stress in animal UC models, pointing to potential new therapeutic approaches. People with UC may want to know about directions in preclinical...

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The Potential Role of the Mediterranean Diet on Clinical Outcomes in Patients with Inflammatory Bowel Disease: A Systematic Review.
Clinical nutrition ESPEN

The Potential Role of the Mediterranean Diet on Clinical Outcomes in Patients with Inflammatory Bowel Disease: A Systematic Review.

Diet is a modifiable factor many people with IBD try to use to feel better. This review summarizes current evidence that a Mediterranean-style eating pattern may help quality of life and is linked to lower inflammation...

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Emerging role of intestinal ultrasound in detecting postoperative recurrence in Crohn's disease.
Gastroenterology report

Emerging role of intestinal ultrasound in detecting postoperative recurrence in Crohn's disease.

Noninvasive tools that reliably detect postoperative recurrence could reduce the need for frequent invasive endoscopy and help target earlier intervention for people with Crohn's disease after surgery.

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Assessing the robustness of clinical trials regarding novel therapies in inflammatory bowel disease.
Gastroenterology report

Assessing the robustness of clinical trials regarding novel therapies in inflammatory bowel disease.

This study looks at how statistically "fragile" results are in trials of new IBD treatments. Patients and clinicians should know that trial size, treatment type, and whether the result was a primary outcome affect how...

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Fulminant Fournier's gangrene following perineal trauma in a patient with suspected chronic inflammatory bowel disease: a case report.
American journal of clinical and experimental urology

Fulminant Fournier's gangrene following perineal trauma in a patient with suspected chronic inflammatory bowel disease: a case report.

Fournier’s gangrene is a life-threatening infection that can occur in people with active intestinal inflammation or after perineal trauma; the case shows how rapidly it can progress and how many surgeries may be needed,...

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Blood heavy metal and trace element levels in newly diagnosed cases of inflammatory bowel disease.
Pakistan journal of medical sciences

Blood heavy metal and trace element levels in newly diagnosed cases of inflammatory bowel disease.

The study suggests nickel accumulation and iron deficiency may be linked with more severe IBD. If confirmed, blood metal and micronutrient levels could help researchers understand disease mechanisms and guide nutritional...

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Microbial predictors of sustained clinical remission following the Crohn's disease exclusion diet in adults and microbiome shifts toward healthy pediatric controls.
Crohn's & colitis 360

Microbial predictors of sustained clinical remission following the Crohn's disease exclusion diet in adults and microbiome shifts toward healthy pediatric controls.

If you or your clinician are considering dietary therapy like the CDED for Crohn's disease, microbiome features at baseline may influence who achieves sustained remission. Understanding these links could help personalize...

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Epitranscriptomic regulation by m6A in immunity and autoimmune disorders: emerging mechanisms and clinical perspectives.
Frontiers in immunology

Epitranscriptomic regulation by m6A in immunity and autoimmune disorders: emerging mechanisms and clinical perspectives.

m6A RNA methylation regulators are emerging as potential targets that may influence immune-driven inflammation in diseases that matter to people with IBD. Understanding these pathways could point toward new precision...

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An Overview of the Rationale and Outcomes of Residential Camps for Children with Inflammatory Bowel Disease.
Pediatric gastroenterology, hepatology & nutrition

An Overview of the Rationale and Outcomes of Residential Camps for Children with Inflammatory Bowel Disease.

Children with IBD commonly experience emotional and social challenges; residential camps appear to improve quality of life, confidence, disease knowledge, and reduce isolation, making them relevant as a supportive,...

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Reactive Therapeutic Drug Monitoring Guides Optimal Management of Adalimumab Failure in Pediatric Crohn's Disease: A Real-World Single-Center Experience.
Pediatric gastroenterology, hepatology & nutrition

Reactive Therapeutic Drug Monitoring Guides Optimal Management of Adalimumab Failure in Pediatric Crohn's Disease: A Real-World Single-Center Experience.

Reactive TDM can help determine why a child with Crohn's disease is losing response to adalimumab and guide whether to escalate dose or switch biologics, which affects short-term management decisions.

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Case Report: Dupilumab-associated ulcerative colitis: elucidating the pathomechanistic link between Th2 blockade and Th17 polarized intestinal inflammation.
Frontiers in immunology

Case Report: Dupilumab-associated ulcerative colitis: elucidating the pathomechanistic link between Th2 blockade and Th17 polarized intestinal inflammation.

The case suggests that blocking IL-4/IL-13 (with dupilumab) might rarely trigger Th17-predominant colonic inflammation presenting as ulcerative colitis; patients and clinicians should be alert for new GI symptoms after...

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Case Report: A rare adult case of ELANE-related severe congenital neutropenia revealed by neutropenic enterocolitis.
Frontiers in immunology

Case Report: A rare adult case of ELANE-related severe congenital neutropenia revealed by neutropenic enterocolitis.

An ELANE mutation causing severe congenital neutropenia can present with neutropenic enterocolitis that mimics ulcerative colitis. Recognizing neutropenia and pursuing genetic testing can prevent misdiagnosis and change...

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Spatial genetic mapping links shared inflammatory bowel disease liability to adult immune-epithelial lesion contexts.
Frontiers in immunology

Spatial genetic mapping links shared inflammatory bowel disease liability to adult immune-epithelial lesion contexts.

Links between IBD genetic risk and specific adult tissue lesion contexts help researchers understand which cell types and tissue programs may mediate inherited susceptibility. That can guide future biomarker and...

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Effectiveness and Safety of Risankizumab in Crohn Disease After Failure of a First Line of Advanced Therapy: A Long-Term, Real-Life Study.
American journal of therapeutics

Effectiveness and Safety of Risankizumab in Crohn Disease After Failure of a First Line of Advanced Therapy: A Long-Term, Real-Life Study.

This real-world, multicenter study suggests risankizumab can induce clinical and steroid-free remission and mucosal healing in many patients with Crohn disease who previously failed advanced therapies, which may be...

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Classifications of rheumatological extraintestinal manifestations in inflammatory bowel disease: Unmet needs in clinical practice and trials.
Inflammatory bowel diseases

Classifications of rheumatological extraintestinal manifestations in inflammatory bowel disease: Unmet needs in clinical practice and trials.

Rheumatological EIMs (notably joint inflammation) are frequent in IBD and affect quality of life; inconsistent definitions and lack of validated PROs make it harder for patients and clinicians to understand and compare...

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Antibiotic Class-Specific Effects on Inflammatory Bowel Disease: Microbiome Disruption, Risk, and Recovery
International Journal of Molecular Sciences

Antibiotic Class-Specific Effects on Inflammatory Bowel Disease: Microbiome Disruption, Risk, and Recovery

Antibiotics can change the gut microbiome in ways that may raise IBD risk or worsen disease for some people. Knowing which antibiotic classes and approaches may be less harmful could help patients and clinicians reduce...

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Expression patterns of miR-21 and miR-146 in ulcerative colitis: implications for disease progression and therapeutic strategies
Journal of Genetic Engineering and Biotechnology

Expression patterns of miR-21 and miR-146 in ulcerative colitis: implications for disease progression and therapeutic strategies

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of Genetic...

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An Early-Stage Study in Multiple Clinics of How Afimkibart May Affect the Body's Processing of Medicines That Rely on Cytochrome P450 Enzymes in Participants With Ulcerative Colitis
ClinicalTrials.gov

An Early-Stage Study in Multiple Clinics of How Afimkibart May Affect the Body's Processing of Medicines That Rely on Cytochrome P450 Enzymes in Participants With Ulcerative Colitis

Patients with UC often take multiple medicines that rely on CYP enzymes. This study is checking if afimkibart affects how those drugs are processed, which could matter for safety or dosing if the drug proceeds in...

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Development and External Validation of a Machine Learning Model for Pre-Endoscopic Prediction of Montreal Disease Extent (E1/E2/E3) in Ulcerative Colitis Using Symptoms, Signs, and Laboratory Tests: A Multicenter Retrospective Observational Study
ClinicalTrials.gov

Development and External Validation of a Machine Learning Model for Pre-Endoscopic Prediction of Montreal Disease Extent (E1/E2/E3) in Ulcerative Colitis Using Symptoms, Signs, and Laboratory Tests: A Multicenter Retrospective Observational Study

A validated pre-endoscopic model could help estimate UC disease extent before colonoscopy, aiding clinical triage and planning without replacing endoscopy.

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Predictive Efficacy of Fecal Calprotectin Assay by Magnetic Particle Chemiluminescence for Mucosal Healing in Moderate-to-Severe Ulcerative Colitis Patients Undergoing Initial Biologic Therapy(PRECAL)
ClinicalTrials.gov

Predictive Efficacy of Fecal Calprotectin Assay by Magnetic Particle Chemiluminescence for Mucosal Healing in Moderate-to-Severe Ulcerative Colitis Patients Undergoing Initial Biologic Therapy(PRECAL)

If validated, an early drop in fecal calprotectin could help identify patients on biologic therapy who are likely to achieve mucosal healing without waiting for invasive endoscopy, allowing earlier decisions about...

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Developing a Self-Management Intervention to Improve Health Outcomes for Patients With Inflammatory Bowel Disease
ClinicalTrials.gov

Developing a Self-Management Intervention to Improve Health Outcomes for Patients With Inflammatory Bowel Disease

Digital self-management programs could help people with active IBD build skills to manage symptoms and quality of life between clinic visits. This trial tests whether such a program is feasible, acceptable, and practical...

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Subcutaneous infliximab in the treatment of patients with perianal fistulizing Crohn's disease: current evidence and emerging roles.
Therapeutic advances in gastroenterology

Subcutaneous infliximab in the treatment of patients with perianal fistulizing Crohn's disease: current evidence and emerging roles.

Perianal fistulizing Crohn's disease is a disabling complication; a subcutaneous form of infliximab could lower treatment burden and expand options if its effectiveness and safety in this specific setting are confirmed.

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Patient Preferences for Inflammatory Bowel Disease Treatment: Results from a Global Survey Conducted in Partnership with the European Federation of Crohn’s & Ulcerative Colitis Associations
The Patient - Patient-Centered Outcomes Research

Patient Preferences for Inflammatory Bowel Disease Treatment: Results from a Global Survey Conducted in Partnership with the European Federation of Crohn’s & Ulcerative Colitis Associations

This global survey shows that people with IBD prioritize symptom relief and psychological well-being over treatment features like administration route or speed of onset. That matters for shared decision-making, trial...

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Spatiotemporally optimized heterotopic transplantation of early-stage small intestinal organoids ameliorates murine ulcerative colitis.
International immunopharmacology

Spatiotemporally optimized heterotopic transplantation of early-stage small intestinal organoids ameliorates murine ulcerative colitis.

If organoid transplantation can be translated to people, it could offer a new way to repair inflamed colonic lining and promote mucosal healing when current therapies are insufficient. The approach also highlights links...

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Reduced fecal GP2 levels in ulcerative colitis associate with inflammatory activity and microbial composition.
Clinica chimica acta; international journal of clinical chemistry

Reduced fecal GP2 levels in ulcerative colitis associate with inflammatory activity and microbial composition.

If fecal GP2 reliably reflects UC activity and microbial changes, it could become a noninvasive marker to track inflammation or to study disease mechanisms that differ between UC and CD.

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New Diagnostic Criteria for Acute Severe Ulcerative Colitis in the Modern Treatment Era: A Modified Delphi Consensus by REFINED-ASUC.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

New Diagnostic Criteria for Acute Severe Ulcerative Colitis in the Modern Treatment Era: A Modified Delphi Consensus by REFINED-ASUC.

The 1955 Truelove and Witts criteria do not account for patients already on modern outpatient therapies. Updated consensus criteria could change how ASUC is recognized and triaged in current clinical practice.

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