Nutrition, food, supplements, exercise, sleep, stress, and lifestyle research for Crohn's disease and IBD.
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This large, population-based study tests whether exposure to outdoor artificial light at night is linked to getting IBD or to later health-care use. Understanding environmental factors that might influence IBD risk or...
Researchers tested manumycin A in a standard mouse colitis model and observed reduced inflammation and tissue injury, suggesting the compound might be a candidate for further IBD drug development.
Point-of-care intestinal ultrasound (IUS) showed strong agreement with follow-up tests and often changed management the same day in a New Zealand IBD cohort. Patients and clinicians may be able to use IUS to monitor...
Based on the title and source metadata, this appears to be a patient education related to Crohn's disease, Inflammatory bowel disease, and Diet and lifestyle. The original article is from hmpgloballearningnetwork.com.
Based on the title and source metadata, this appears to be a patient education related to Crohn's disease and Diet and lifestyle. The original article is from hmpgloballearningnetwork.com.
The paper identifies a specific bacterial metabolite-receptor pathway (succinic acid → SUCNR1 → NF-κB) by which Fusobacterium nucleatum may worsen intestinal inflammation, suggesting new targets for IBD research and...
The oral microbiome can influence gut microbes and inflammation; understanding this link could lead to new diagnostic markers (saliva) or combined dental–gastroenterology care approaches relevant to people with IBD.
New or improved fluorescent probes could enable more sensitive, noninvasive imaging of biochemical changes in the gut, which may aid research, earlier diagnosis, or monitoring of IBD and colorectal cancer.
ER stress in intestinal epithelial cells is proposed as a key molecular mechanism in UC development; targeting ER pathways (notably IRE1β) could eventually lead to new treatments that strengthen the gut barrier and...
The report suggests adding acupuncture to anti-TNF therapy may improve short-term symptom control and mucosal healing and reduce early colectomy risk for a TCM-defined subgroup of ulcerative colitis patients, which could...
This registered trial tests whether an adapted Crohn’s Disease Exclusion Diet can match or outperform the low‑FODMAP diet for non‑constipated IBS while targeting low‑grade inflammation, gut barrier function, and...
Ultra-processed foods are common in youth diets and may affect overall diet quality; this study is testing whether short, practical nutrition education can reduce UPF intake in children and teens with IBD. If effective,...
Dietary strategies that change the gut microbiome are of interest because they might modify inflammation without drugs. This study suggests PEN+ED can shift the microbiome toward a healthier profile in UC, though...
Accessible, culturally tailored digital education can help close IBD health-literacy gaps in Latin America; improved knowledge may help people better manage care, ask informed questions, and engage with clinicians.
Mitochondrial dysfunction may be a central contributor to UC inflammation and is being targeted by new therapeutic strategies that could lead to different treatment approaches in the future.
Shows real-world long-term outcomes in a large Chinese UC cohort and highlights that baseline disease activity predicts need for escalation and colectomy risk; points to opportunities to improve treat-to-target care.
Malassezia extracellular vesicles can modulate immune and microbial interactions; if similar mechanisms affect the gut, they could be relevant to inflammatory bowel disease and Crohn’s disease, though current evidence is...
If environmental microplastics contribute to gut dysbiosis and mucosal inflammation, this could help explain environmental triggers of ulcerative colitis and point toward prevention or microbiome-targeted interventions.
Researchers used a standard mouse colitis model to show a traditional herbal formula reduced inflammation and improved gut barrier markers, implicating the IL-33/ST2 immune pathway. This could guide future preclinical...
The study identifies a cellular mechanism by which arctigenin reduced inflammatory macrophage death and improved colitis in mice, suggesting a potential new target (macrophage FAO → GSDMD) for therapies or...
A coordinated national research network can accelerate studies that matter to people with IBD—like tracking real-world disease patterns, testing diet and psychosocial approaches, improving monitoring with biomarkers and...
Algorithms guide how UC is diagnosed and monitored (endoscopy, labs, fecal markers, imaging) and when to escalate to surgery or other interventions; that affects surveillance, treatment choices, and complication...
This study synthesizes randomized trial evidence about the role of gut microbiota in ulcerative colitis and whether fecal microbiota transplantation (FMT) can help induce remission. People with UC may encounter FMT as a...
The study suggests dietary tryptophan might reduce bacterial-induced acute lung injury in the context of colitis by altering gut–lung immune signaling, which could be relevant to IBD patients who are at risk for...
This study identifies molecular targets and organoid-based effects of ganoderic acid A on inflammatory pathways relevant to IBD, pointing to a potential multi-target avenue for future drug-discovery research.
This registry will provide real-world data on how etrasimod is used and performs in routine clinical practice in China, including patient characteristics, symptom trajectories, safety, and healthcare costs. Real-world...
People with IBD often look for safe, low-cost adjuncts to medical therapy. This review compiles mechanisms by which dietary polysaccharides could support gut barrier function, beneficial microbes, and anti-inflammatory...
The work links intestinal inflammation with neurobehavioral changes in a mouse colitis model and suggests certain p‑coumaric acid derivatives can reduce inflammation and anxiety/depression‑like behaviors, which could...
Diet is a modifiable factor that appears to change the gut microbiome and may affect symptoms and inflammation in both IBS and IBD; understanding which patterns help could guide practical dietary advice.
The study maps how two ginger preparations differently affect metabolism and the gut microbiome in a mouse model of ulcerative colitis, which could inform more targeted use of ginger-derived treatments if findings are...
Researchers are exploring plant-based formulas for inflammation beyond the gut. If the SGD effects translate to humans, it could point to new ways to prevent or treat liver injury that can accompany active UC by...
The study identifies a previously unrecognized protein (TNFAIP1) that appears to promote inflammation in ulcerative colitis and proposes a compound (Salidroside) that directly binds and inhibits it in lab and mouse...
New targeted delivery approaches aim to concentrate therapy in the gut lining and inflamed areas, which could improve effectiveness and reduce systemic side effects for people with IBD.
This review collects preclinical evidence that a traditional Chinese medicine formula (Gegen Qinlian Decoction) may act on inflammation, the gut barrier, immunity, and microbiota — all relevant to ulcerative colitis and...
The study describes a new oral-delivery microsphere that improved loading and gut-targeted release of celastrol and showed beneficial effects in a mouse colitis model and on gut microbiota. If translatable, this approach...
The study synthesizes many stool metagenomes to find consistent microbial species, functional pathways, and strain-level differences linked to IBD and to distinctions between Crohn’s disease and ulcerative...
This study identifies a plant-derived polysaccharide (from the stem of Dendrobium huoshanense) that reduced inflammation and tissue injury in a mouse model of ulcerative colitis and points to GLP-1 signaling as a likely...
Nanoparticle technologies could eventually enable more targeted drug delivery and improved imaging for IBD and related GI diseases, which may lead to better diagnosis and less systemic side effects. However, translation...
Researchers are exploring methods to make probiotic therapies more stable through the digestive tract and to deliver anti-inflammatory molecules directly where intestinal inflammation produces high reactive oxygen...
Gut microbes produce small molecules that interact with the host. This study shows lower levels of certain microbial aromatic carboxaldehydes (I3A and 4HBA) in feces from people with Crohn’s disease, suggesting a...
Fibrosis and stricturing are key problems in Crohn’s disease with limited therapies; this study identifies a microbiota–bile acid–GPBAR1 pathway by which a specific probiotic mix reduced inflammation and fibrosis in...
This review spotlights non-bacterial members of the gut microbiota (viruses and fungi) that may contribute to IBD by altering barrier function, immune responses, and interactions with bacteria. For people with IBD, these...
Researchers are exploring microbiome-derived molecules as targeted, locally acting therapies for ulcerative colitis that might avoid systemic immunosuppression. EB1010 showed anti-inflammatory activity and...
The study suggests a new host-directed mechanism that helps a common beneficial gut bacterium (Faecalibacterium prausnitzii) colonize and protect the gut lining, and identifies heparan sulfate as a potential way to...
The review shows increasing research linking ferroptosis to autoimmune diseases including IBD and ulcerative colitis, which may guide future biomarker and therapy research relevant to people with Crohn's disease or other...
This preclinical study suggests an herbal capsule formulation reduced colitis severity and shifted markers of oxidative stress, inflammation, and ferroptosis in mice — signaling possible biological pathways for future...
The study suggests that while Crohn's disease produces a shared dysbiotic signature at diagnosis, the specific microbes enriched differ by age — notably oral-associated taxa in children — which could affect research into...
Researchers used machine learning to prioritize microbiome-related regulatory targets in Crohn's disease, which may guide future lab and clinical research into microbial pathways (like butyrate-related metabolism) that...
