Nutrition, food, supplements, exercise, sleep, stress, and lifestyle research for Crohn's disease and IBD.
Page 19 of 24 · 1124 articles
The study links ER stress and defective autophagy to increased claudin-2 and tight-junction dysfunction—mechanisms relevant to barrier loss in IBD. Targeting this pathway could eventually inform therapies to preserve...
The review examines whether removing the appendix could change the course of ulcerative colitis — a potential surgical option that might lower colectomy or hospitalization risk in some scenarios but also carries...
The article points to plant-derived compounds with anti-inflammatory and antioxidant actions that may be relevant to colitis mechanisms, which could be of interest to patients and clinicians following experimental or...
The study suggests Artemisia rupestris extract can reduce inflammation, repair the intestinal barrier, and shift the gut microbiota and metabolites in a mouse colitis model — pathways that are important in IBD. These...
The study investigates how components of exclusive enteral nutrition (EEN), particularly transforming growth factor‑β (TGF‑β), may help restore intestinal barrier function after colitis. That could help explain why EEN...
A treatable-traits approach could help tailor IBD care to each patient by targeting specific biological, comorbid, and psychosocial drivers of disease and quality-of-life impairment, potentially improving how we choose...
AI could help identify dietary patterns, predict which patients might benefit from specific nutrition approaches, and provide personalized nutrition support — potentially improving inflammation and gut microbiome...
Oxidative stress may help explain some biological drivers of inflammation in Crohn’s disease and ulcerative colitis and could become a target for biomarkers or therapies in the future. Right now, the evidence is...
Patients and clinicians often ask whether herbal formulas or plant compounds can help IBD. This preclinical study identifies quercetin and the PI3K–Akt pathway as potential mechanisms, which may guide future research...
People with ulcerative colitis may be interested because synbiotic approaches aim to change the gut microbiome and intestinal barrier and therefore could become a future therapeutic option or adjunct. The paper...
The paper suggests that loss of microbial bile acid transformations in IBD reduces activation of the TGR5 receptor, and that lower TGR5 bioactivity correlates with higher inflammatory activity — a potential mechanism...
The study identifies a plant-derived compound that reduced inflammation and liver injury in a mouse model of ulcerative colitis and ties its effects to both JAK2/STAT1 inhibition and changes in the gut microbiota—two...
Fecal calprotectin measured by a point‑of‑care CGICA assay showed high accuracy for identifying colorectal inflammation and IBD in patients with chronic diarrhea, which could help avoid some unnecessary colonoscopies...
The study suggests nanoplastic particles can alter intestinal barrier function, goblet cells, mucin secretion, and inflammation-related gene expression in models with genetic susceptibility to Crohn’s disease.
Non-invasive biomarkers that reflect mucosal inflammation and systemic disease activity could help reduce reliance on frequent endoscopy and guide monitoring for people with Crohn’s disease or ulcerative colitis.
Chronic pain affects many people with IBD even after inflammation is controlled, often limiting daily activities and worsening mental health. Understanding that pain can persist without active inflammation highlights the...
Probiotics like Lactobacillus GG are often considered by families of children with Crohn’s disease. If helpful, they could offer a low-risk adjunct that targets the gut microbiome and barrier function. This pilot study...
The study describes a new oral nanotherapy that delivered apremilast to the inflamed colon in mice and reportedly reduced gut inflammation and behaviors resembling anxiety/depression—suggesting a combined...
The study describes a new oral, colon‑targeted delivery system that improved outcomes in a mouse model of ulcerative colitis and shifted immune and microbiome markers—research that could inform future therapies focused...
This study suggests a specific probiotic strain may help reduce colitis in mice by changing the gut microbiome and boosting host phosphatidylcholine production — a pathway that could be relevant to gut barrier repair in...
Researchers exploring new anti-inflammatory or antioxidant compounds for ulcerative colitis may find sanggenol L’s effects on Nrf2/HO-1 and TLR4/p65 signalling of interest. Patients should note this is early-stage,...
Cure8 found this source from Journal of gastroenterology and hepatology, but the page could not be read reliably yet. It is tagged for Inflammatory bowel disease and Diet and lifestyle. Open the original article for the...
People with IBD often receive general advice to eat more fiber, but certain purified fibers or fiber-enriched foods may help some people while worsening inflammation in others. Research that teases apart fiber types and...
Understanding gene–microbe interactions that drive site-specific disease in very early-onset Crohn’s could reveal why some children develop ileal versus colonic disease and suggest new approaches to prevention or...
This study highlights factors—tumor location, age, smoking, and having IBD—that were associated with survival and progression in a Lebanese CRC cohort.
Based on the title and source metadata, this appears to be a patient education related to Tests and monitoring. The original article is from msn.com.
Adherent-invasive E. coli (AIEC) is implicated in Crohn’s disease inflammation in some patients. This review maps possible ways to target AIEC specifically, which could lead to therapies that reduce infection-driven...
The study identifies a gut bacteria–liver signaling axis (Lactobacillus johnsonii → hepatic LXRα–SCD1) that may explain how altered hepatic lipids contribute to UC and related liver injury, and shows pristimerin can...
Standard measures like BMI and routine labs can miss muscle and fat depletion in IBD patients. Better screening plus access to dietitian assessment could find treatable malnutrition that affects recovery and quality of...
The study identifies a food-derived compound that improved colitis in lab models and acted on JAK/STAT3 signaling and intestinal barrier proteins—pathways relevant to IBD inflammation and mucosal healing.
Biomaterials that directly modify immune responses could offer new localized, targeted ways to treat gut inflammation, potentially reducing reliance on systemic immunosuppressive drugs. This review summarizes preclinical...
Sexual dysfunction is common in IBD and—according to this study—appears more strongly linked to psychological and demographic factors than to disease activity or muscle loss. Recognizing and treating mental-health issues...
The study describes a new urine-based fluorescent biosensor that detected inflamed intestinal sites and tracked treatment response earlier and more sensitively than fecal calprotectin in a mouse model of IBD, which could...
Self‑management programs delivered by nurses may help people with IBD improve daily functioning, confidence in managing their condition, and quality of life even when inflammation markers don’t change. That matters...
Identifies a microbiome-derived protein that inhibits a protease linked to epithelial damage in IBD and shows protective effects in lab and mouse models, pointing to a new therapeutic strategy focused on barrier...
This study describes a local rectal therapy that combines mesalamine with probiotic‑derived extracellular vesicles to promote mucosal healing and reduce inflammation in ulcerative colitis models, which could point toward...
Summer brings more social eating, travel, and foods that can trigger IBD symptoms. Practical, lower-risk treat options can help people with ulcerative colitis or Crohn’s enjoy events while reducing the chance of...
The article helps patients and caregivers recognize common symptoms and complications, understand causes and risk factors, and see why ongoing specialist care and lifestyle measures matter for long-term management.
Changes in gut permeability are thought to relate to intestinal barrier function and symptoms in UC and IBS-D. If Aquamin alters permeability, it could suggest a mechanism for symptom or disease-modifying effects and...
The study suggests a plant-derived AHR-activating mechanism that reduced inflammation and repaired the intestinal barrier in preclinical ulcerative colitis models, a pathway that could be relevant to future therapies or...
The review highlights how microbial metabolites, epigenetic regulation, and mitochondrial metabolism interact to shape inflammation and barrier function in IBD. Understanding these links could help identify new...
Zinc deficiency is common in UC, and this study suggests that changes in zinc‑dependent enzyme activity in the gut lining are linked with local inflammation. If confirmed, mucosal enzyme activity might help explain...
Non-invasive urine biomarkers could make diagnosis and disease-activity monitoring easier and less invasive for people with IBD. Identifying metabolites linked to UC activity may help tailor monitoring without frequent...
Dietary strategies that reduce inflammation and oxidative stress could complement medical care for people with IBD by potentially lowering biomarkers linked to disease activity.
The study links depleted fatty acid oxidation metabolites—especially butyrate—to impaired regulatory T cell development in IBD, suggesting a metabolic pathway that may influence immune tolerance and disease activity.
The review suggests MSCs and their exosomes can change the gut microbiome, a factor implicated in IBD and liver disease, pointing to a potential new therapeutic approach. Patients and clinicians interested in future IBD...
Markers of systemic inflammation (CRP and ESR) were consistently higher in people with obesity across Crohn’s disease, ulcerative colitis, psoriasis, and psoriatic arthritis, suggesting body weight may influence...
Some people with ulcerative colitis seek complementary or herbal treatments. This review reports research on a modified Gegen Qinlian Decoction that the authors say may strengthen the gut barrier and reduce inflammation,...
