Nutrition, food, supplements, exercise, sleep, stress, and lifestyle research for Crohn's disease and IBD.
Page 18 of 24 · 1124 articles
This preclinical study suggests quince gel reduced inflammation, oxidative stress, and tissue injury in a rat model of ulcerative colitis and identifies quercetin as a likely active component. Findings point to possible...
Metformin is a common, inexpensive drug with possible anti-inflammatory effects; this review compiles preclinical and early clinical data suggesting it might influence ulcerative colitis biology. Readers may want to know...
Perianal fistulizing Crohn’s disease causes delayed healing and high recurrence after surgery. This study suggests a specific time-guided external traditional therapy may speed wound healing, reduce inflammation, and...
This NIH-funded project identifies probiotic metabolic pathways that protect gut barrier integrity in a diet-dependent way, which could explain mixed clinical trial results and point to biomarkers to select patients...
Researchers are trying to create modular mucosal immunotherapies that target both microbial and inflammatory drivers of diseases like colitis. If successful, this approach could lead to treatments that address the...
This project explores how gut microbes and bile acids interact to shape immune cells in the ileum — a process that may affect inflammation in Crohn’s disease and other IBDs. Understanding these mechanisms could point to...
The study identifies a fungal β-glucan that reduced inflammation and altered the gut microbiome and short-chain fatty acids in a mouse model of ulcerative colitis, which could inform future nutritional or therapeutic...
Dietary changes are common among people with IBD but long-term adherence is low; understanding what patients find acceptable and what barriers they face can help clinicians design practical, culturally sensitive dietary...
Altered NAD metabolism may influence inflammation and tissue repair in IBD; understanding host and microbial contributions could open new research directions for metabolic biomarkers or therapeutic targets.
Integrated joint appointments could make it easier for children with IBD and their families to get coordinated care for symptoms, nutrition, and mental health in a single visit, which may improve access and reduce stigma...
ECCO 2026 presented multiple studies that could change IBD care across prevention, medical therapy (including pediatric data), complication‑directed strategies (perianal fistula), and technology‑assisted monitoring....
PTG and psychological wellbeing matter to many people with IBD. This study indicates that addressing stigma and promoting healthy lifestyle behaviours could be linked with better psychological outcomes, making these...
Many people with UC try dietary changes to manage symptoms. This randomized pilot trial directly compared two popular diets and did not find a clear difference in symptom improvement, but high dropout limits confidence.
This mouse study identifies a novel peptide that reduced DSS-induced colitis and points to mast cells and fibroblast–mast cell interactions as potential therapeutic targets. It also showed additive benefit when combined...
Nanotechnology is being heavily explored as a way to improve drug targeting, control release, and reduce systemic toxicity in IBD — topics that could shape future treatment options and research priorities.
Mood disorders commonly co-occur with chronic somatic diseases, including IBD; understanding shared mechanisms may explain worse outcomes and suggest multidisciplinary care needs.
The study explores a novel method to reduce gut oxidative stress — a contributor to IBD inflammation — by using an engineered probiotic to edit NOX2, which could point toward new therapeutic strategies if translated to...
Kidney dysfunction can occur in people with IBD and may be under-recognized. A validated prediction model could help clinicians identify IBD patients at higher risk and prompt earlier monitoring or interventions.
This article suggests a naturally derived compound (isorhamnetin) identified from TCM may reduce inflammation in experimental ulcerative colitis and points to the Nrf2–PTGS2 pathway as a possible mechanism. That could...
The paper identifies microbiome-derived peptides that can directly block TLR4 signaling and reduce intestinal inflammation in mice; this reveals a new microbiome–immune mechanism that could inform future IBD treatments.
Metabolic syndrome appears common in this Tunisian IBD cohort (about one-third). MetS can affect overall health and may influence long-term outcomes for people with IBD, so awareness and cardiometabolic screening may be...
The study suggests that in IBD the gut microbiome’s functional impact on immune signalling is shifted toward inflammation even when composition appears similar to controls.
The study links a traditional herbal formula to improved colitis in mice and to changes in bile-acid metabolism through the FXR–FGF15 pathway, suggesting a mechanistic route that could inform future preclinical or...
Sarcopenia is common in Crohn's disease and is linked to worse outcomes; a simple GNRI-based prediction tool could help identify at-risk patients without routine CT scanning.
This meta-analysis suggests people with IBD face higher risks of major cardiovascular events (heart attack, ischemic heart disease, ischemic stroke), which may matter for monitoring and preventive care. Higher risk...
Researchers report links between copper-driven cell death pathways and IBD biology; identifying cuproptosis-related biomarkers or drugs could open new diagnostic or therapeutic avenues for people with Crohn's disease or...
This review summarizes many observational studies to identify dietary and environmental factors that may influence the risk of developing ulcerative colitis, which could help guide future research and prevention efforts...
The review suggests matrine and oxymatrine reduce inflammation and oxidative stress in animal UC models, pointing to potential new therapeutic approaches. People with UC may want to know about directions in preclinical...
Diet is a modifiable factor many people with IBD try to use to feel better. This review summarizes current evidence that a Mediterranean-style eating pattern may help quality of life and is linked to lower inflammation...
Noninvasive tools that reliably detect postoperative recurrence could reduce the need for frequent invasive endoscopy and help target earlier intervention for people with Crohn's disease after surgery.
The study suggests nickel accumulation and iron deficiency may be linked with more severe IBD. If confirmed, blood metal and micronutrient levels could help researchers understand disease mechanisms and guide nutritional...
If you or your clinician are considering dietary therapy like the CDED for Crohn's disease, microbiome features at baseline may influence who achieves sustained remission. Understanding these links could help personalize...
Children with IBD commonly experience emotional and social challenges; residential camps appear to improve quality of life, confidence, disease knowledge, and reduce isolation, making them relevant as a supportive,...
Digital self-management programs could help people with active IBD build skills to manage symptoms and quality of life between clinic visits. This trial tests whether such a program is feasible, acceptable, and practical...
Early intestinal ultrasound may predict one-year endoscopic remission in Crohn's disease, offering a noninvasive tool to guide treatment decisions and possibly reduce the need for some colonoscopies.
This global survey shows that people with IBD prioritize symptom relief and psychological well-being over treatment features like administration route or speed of onset. That matters for shared decision-making, trial...
The study suggests a multi-component herbal formula may affect inflammation, the intestinal barrier, epithelial repair, the gut microbiome, and fecal metabolites in a mouse colitis model—topics relevant to understanding...
Oat beta-glucan is a dietary fibre with prebiotic properties; the review suggests potential benefits seen in animal studies but shows human evidence is limited. Patients and clinicians may care because dietary fibres are...
Dietary therapy (CDED + PEN) was associated with longer remission when families adhered well; since adherence varies, support from a dietitian matters for keeping children in remission.
A patient-centered journey map identifies changing symptom, psychological, and social needs at different stages of Crohn's disease. That can help clinicians and care teams target education, mental-health support, and...
People with ulcerative colitis may be interested because ferulic acid is a plant-derived compound that, in lab and animal studies, appears to reduce gut inflammation, support the intestinal barrier, and positively...
This study describes a lab-stage engineered probiotic–silver nanoparticle therapy that reduced inflammation and promoted colon repair in an animal colitis model; it highlights new molecular targets (Wnt signaling and...
Strictures raise the risk that food will get stuck and cause a dangerous blockage. Simple changes to texture, portion size, and eating habits can lower that risk and help you keep a varied diet.
FUT2 connects genetics, mucosal sugars, and the gut microbiome — pathways that could help explain why some people with IBD have different microbiomes or disease risk. If validated in trials, FUT2-targeted or...
The study identifies a specific polysaccharide fraction (VPS-30) that reduced inflammation and improved gut barrier markers in cell and mouse models of colitis, suggesting a possible new functional-food lead for...
Researchers and clinicians are exploring cGAS/STING as a novel immune pathway linked to mucosal barrier function and inflammation in UC. Modulators of this pathway could become future targeted treatments, so patients and...
The editorial outlines treatment strategies that could affect whether a person with ASUC avoids colectomy, highlights the importance of getting adequate infliximab exposure, and summarizes emerging drug classes that may...
Exercise is a low-cost, accessible intervention that may improve quality of life and reduce symptoms in people with IBD. This pooled analysis suggests some exercise types — especially regular continuous aerobic exercise...
