Evidence types
Clinical study articles covering observational research, trial reports, and human data relevant to Crohn's disease and IBD.
Page 4 of 21 · 1007 articles
Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Research and clinical trials. The original article is from Journal of the Canadian Association of...
Researchers are exploring ways to deliver steroids like budesonide more precisely to the intestine while avoiding stomach leakage and sudden drug release. If translated to humans, such a formulation could improve local...
Transmural healing on CT enterography was associated with fewer hospitalizations over long follow-up, which could matter for long-term disease management and monitoring strategies in Crohn’s disease.
Perianal fistulas are common and burdensome in Crohn’s disease; this large multicenter Korean study quantifies high rates of complex fistulas, frequent recurrence, and suggests biologic therapy is associated with fewer...
Cure8 could only read part of this source from Intestinal Research, so this card uses cautious topic tags instead of a full summary. It is tagged for Ulcerative colitis, Crohn's disease, and Inflammatory bowel disease.
A reliable endoscopic method that matches histology could reduce the need for biopsies and speed decisions about remission and treatment in UC. Patients and clinicians interested in noninvasive, real‑time inflammation...
Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Research and clinical trials. The original article is from The American journal of gastroenterology.
Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease, Microbiome, and Research and clinical trials. The original article is from Nature Reviews...
Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Microbiome. The original article is from Nano Today.
Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Microbiome, and Diet and lifestyle. The original article is from Probiotics and Antimicrobial Proteins.
For people with Crohn’s disease, this study suggests that biologic drugs reduce inflammation in both proximal and distal small bowel to a similar degree, as measured by capsule endoscopy.
Microbiome patterns in this study were linked to inflammation (fecal calprotectin) and higher chance of needing treatment escalation. If validated, enterotype stratification could help predict disease course or tailor...
For people with UC who do not respond to tacrolimus, adding infliximab may induce remission and reduce the short-term need for colectomy. The findings point to a potential rescue strategy and an option to transition to...
This project explores whether common environmental chemicals (PFAS) might change biological processes years before IBD appears, which could help explain some cases of Crohn’s disease and ulcerative colitis and point...
Patients and clinicians choosing a next biologic after prior biologic failure may find evidence here that effectiveness is broadly similar between vedolizumab and ustekinumab overall, with potential differences depending...
If validated, mucosal biomarkers like SPARC and SPP1 might help predict who will not respond to infliximab, potentially guiding treatment choices and avoiding ineffective therapy for some people with UC.
The study suggests IBD patients can fall into two distinct gut-microbe/metabolite types that align with differences in disease severity and mental-health scores, which could help explain why patients with the same...
The study identifies and functionally validates a new STXBP3 variant that likely causes VEOIBD with immunodeficiency, which can help explain disease in affected infants and inform genetic counseling and further research.
Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease, Microbiome, and Research and clinical trials. The original article is from Gut Pathogens.
Understanding whether innate lymphoid cells retain ‘memory’ that drives psoriasis relapse could reveal biomarkers to monitor recurrence and suggest new therapeutic targets for patients with recurrent disease.
People with IBD on biologic therapies may benefit from accurate drug-level testing to guide treatment decisions.
Patients with multiple biologic failures appear more likely to have inflammatory comorbidities (including IBD) and to experience worse dermatology-related quality of life despite similar early skin improvement. That...
PSC co-occurring with celiac disease appears more common than expected and is associated with a high rate of liver complications (including cirrhosis) and frequent coexisting IBD—information that may affect monitoring...
The study suggests adding a structured 16-week exclusive enteral nutrition plan to ustekinumab treatment may improve short- and medium-term clinical and endoscopic outcomes for adults with moderate-to-severe Crohn’s...
Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Microbiome. The original article is from AMB Express.
The work aims to improve colon-targeted delivery of an aminosalicylate (balsalazide) to boost local drug levels and protect the drug from gastric degradation—potentially relevant to people with ulcerative colitis looking...
Stigma and avoidance can harm social and work functioning for people with IBD. Knowing which factors increase avoidance (visible symptoms, prolonged contact, absence of a diagnosis label) can help patients and clinicians...
The study links a common compound in plant foods (oxalate) to intestinal inflammation in IBD, suggesting diet and oxalate metabolism may be modifiable contributors to flares.
The work helps explain why smoking increases Crohn’s risk but seems protective for ulcerative colitis by identifying genetic loci and smoking-dependent gene expression changes that differ between the two diseases. That...
If genetics helps explain who develops Crohn’s disease, better ways to pick the handful of important variants could speed discovery of biological mechanisms and future tests.
Shortening ustekinumab dosing intervals raised drug levels and was associated with high rates of steroid-free clinical remission in this small prospective IBD cohort, offering a practical option for patients who lose...
Predicting which patients with acute severe ulcerative colitis will need colectomy or will not respond to steroids can guide early treatment decisions. This study shows that important predictors differ between East Asian...
AI models are being developed to support IBD care (activity scoring, risk prediction), but most studies are retrospective and don’t yet demonstrate that AI outputs reliably change clinical decisions or improve outcomes....
Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Cell Biology and...
Simpler patient-reported scores (PRO2/PRO3) were much more often available in routine clinic visits than CDAI or HBI, yet they agreed closely with those indices. That could make regular monitoring and telehealth...
A multimodal, simpler activity score could improve practical disease monitoring when full ileocolonoscopy isn’t possible and help standardize treat-to-target practice across centers.
FMT is an active area of research that could affect future IBD treatments; patients with IBD commonly experience obesity and complex care decisions. Updates on FDA-approved FMT products and ongoing Crohn’s studies may...
Interstitial lung disease (ILD) is an underrecognized extraintestinal complication in IBD that in this study was relatively common (12%) and associated with a substantially increased risk of death.
A validated prediction score that reliably rules out clinically significant CT findings could reduce unnecessary CT imaging, radiation exposure, and costs for people with Crohn's disease experiencing acute symptoms.
Circulating glycoprotein signals may help explain how systemic inflammation in IBD interacts with metabolic liver disease (MASLD). If validated, they could improve risk stratification for liver complications beyond...
IBD and obstructive sleep apnea may influence each other through shared biological processes (barrier dysfunction, dysbiosis, immune activation, intermittent hypoxia), so understanding this could affect screening and...
The work suggests specific host genes and cell types that might mediate links between gut microbes and IBD, which could direct future laboratory research into mechanisms and potential biomarkers.
This case series points to risankizumab as a potential option for children with IBD who have failed multiple biologics, and it reports use of noninvasive monitoring like intestinal ultrasound.
Children with Crohn's and their clinicians often need noninvasive, accessible ways to monitor small-bowel disease. If validated elsewhere, IUS with the reported BWT thresholds could reduce reliance on MRE, which is...
If validated, AI-enhanced vascular assessment during endoscopy could give clearer, more reproducible information about mucosal and histologic healing — which matters for monitoring disease activity and guiding treatment...
Hospitalized patients with acute severe ulcerative colitis often need rescue therapy to avoid colectomy.
Non-specialist physicians often manage IBD where specialists are scarce. If reliable, AI tools could improve non-specialists' clinical reasoning and decision-making for IBD care.
The paper identifies subtype-specific changes in enteric glial cells and mast cell activity in microscopic colitis and shows some treatment-associated reductions after budesonide; that helps explain disease biology and...
