Condition

Crohn's disease

Crohn's disease news across medications, symptoms, tests, procedures, complications, research, access, and daily life.

Page 21 of 53 · 2520 articles

High prevalence of fatigue in patients with inflammatory bowel disease: association with physical activity intensity and sedentary behavior
Frontiers in Public Health

High prevalence of fatigue in patients with inflammatory bowel disease: association with physical activity intensity and sedentary behavior

Fatigue is very common in people with IBD—even when the disease is in remission—and is linked with lower physical activity, more sitting time, and with anxiety/depression. Understanding these links may help patients and...

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Diet quality, gut microbiome, and inflammatory signatures in Puerto Rican adults with Crohn disease: a multidimensional analysis.
Inflammatory bowel diseases

Diet quality, gut microbiome, and inflammatory signatures in Puerto Rican adults with Crohn disease: a multidimensional analysis.

Diet quality was linked to gut microbiome features and exploratory differences in inflammatory markers and symptoms in adults with Crohn disease from Puerto Rico; understanding these links may help tailor dietary...

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CD226 associates with interferon and inflammatory programs in intestinal γδ T and group 3 innate lymphoid cells in Crohn's disease.
Biochemical and biophysical research communications

CD226 associates with interferon and inflammatory programs in intestinal γδ T and group 3 innate lymphoid cells in Crohn's disease.

The study points to CD226 (DNAM-1) being linked to inflammatory and interferon-driven programs in specific intestinal immune cells in Crohn's disease, which may be relevant to understanding disease mechanisms or...

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Cost Per Remission of Vedolizumab Versus Risankizumab for the Treatment of Moderately to Severely Active Crohn's Disease in Italy.
Advances in therapy

Cost Per Remission of Vedolizumab Versus Risankizumab for the Treatment of Moderately to Severely Active Crohn's Disease in Italy.

Patients, clinicians, and payers may care because the analysis addresses the relative economic value of two approved biologic options (vedolizumab and risankizumab) for Crohn’s disease treatment in Italy and could...

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Childhood exposure to a sibling with Crohn's disease alters gut microbiome and Crohn's disease susceptibility.
Gut

Childhood exposure to a sibling with Crohn's disease alters gut microbiome and Crohn's disease susceptibility.

Because having a sibling with Crohn's disease during childhood was linked to substantially higher risk of developing Crohn's later, and the study points to early-life microbiome differences and elevated faecal...

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Hyperbaric Oxygen Therapy for Perianal Fistulizing Crohn's Disease Not Responsive or Intolerant to Conventional Care: HYPNOTIC Pilot Study
ClinicalTrials.gov

Hyperbaric Oxygen Therapy for Perianal Fistulizing Crohn's Disease Not Responsive or Intolerant to Conventional Care: HYPNOTIC Pilot Study

Perianal fistulizing Crohn’s disease is difficult to treat and many patients don’t respond to available medical and surgical options. This trial tests an existing wound‑healing therapy (HBOT) in a formal controlled...

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A First-time in Human (FTIH) Study to Evaluate Safety, Tolerability, Pharmacokinetics and Target Engagement of GSK4528287 in Healthy Participants
ClinicalTrials.gov

A First-time in Human (FTIH) Study to Evaluate Safety, Tolerability, Pharmacokinetics and Target Engagement of GSK4528287 in Healthy Participants

Researchers and patients tracking new IBD therapies may care because this is the first human study of a GlaxoSmithKline investigational drug aimed at colitis/ulcerative colitis — an early step that could lead to future...

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From mesenchymal stem cells to myoblast cell sheets: A next-generation regenerative concept for fistulizing Crohn’s disease
World Journal of Stem Cells

From mesenchymal stem cells to myoblast cell sheets: A next-generation regenerative concept for fistulizing Crohn’s disease

Fistulizing Crohn’s disease is a major complication where durable structural repair is hard to achieve. Regenerative cell-sheet approaches aim to rebuild tissue architecture rather than only suppress inflammation, which...

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Modifiable lifestyle factors in early life and inflammatory bowel disease risk in two birth cohorts.
Journal of Crohn's & colitis

Modifiable lifestyle factors in early life and inflammatory bowel disease risk in two birth cohorts.

The study suggests that modifiable early-life factors (feeding, antibiotic exposure, activity, BMI, smoke exposure, delivery mode, diet) may influence the later risk of IBD, especially Crohn's disease, which could be...

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Development of a Claims-Based Algorithm and Validation Through Medical Chart Review to Identify Patients with Crohn’s Disease-Related Fibrostenosis: A Retrospective Observational Study in the United States
Advances in Therapy

Development of a Claims-Based Algorithm and Validation Through Medical Chart Review to Identify Patients with Crohn’s Disease-Related Fibrostenosis: A Retrospective Observational Study in the United States

A validated claims-based algorithm could enable larger, more efficient studies of fibrostenosis in Crohn’s disease using real-world data — helping researchers and clinicians better measure how often stricturing...

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Incremental Value of Traditional Chinese Medicine Features in Two-Stage Pre-Endoscopic Prediction
ClinicalTrials.gov

Incremental Value of Traditional Chinese Medicine Features in Two-Stage Pre-Endoscopic Prediction

Researchers are exploring ways to prioritize who needs colonoscopy sooner; adding TCM features to prediction models might change triage performance. Patients and clinicians interested in pre-endoscopic risk tools or...

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TikToker With Crohn’s Disease Got a $103,718 Hospital Bill for Five Nights — Two of Them Were on a Gurney in the Hallway — Insurance Left Her With $1,200
yahoo.com

TikToker With Crohn’s Disease Got a $103,718 Hospital Bill for Five Nights — Two of Them Were on a Gurney in the Hallway — Insurance Left Her With $1,200

This story highlights how hospital billing, administrative errors, and gaps in hospital care (privacy, dietary needs) can create financial and emotional stress for people with Crohn’s disease. It underscores broader...

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Dyspareunia and heavy menstrual bleeding as clinical predictors of concomitant endometriosis in Inflammatory Bowel Disease: A multidisciplinary prospective study.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver

Dyspareunia and heavy menstrual bleeding as clinical predictors of concomitant endometriosis in Inflammatory Bowel Disease: A multidisciplinary prospective study.

Endometriosis may coexist with IBD and can cause pelvic pain, painful sex, and heavy periods—symptoms that may be mistaken for bowel disease activity. Identifying endometriosis could change evaluation and management for...

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Epigenetic changes in stromal cells drive disease-promoting tissue niches - Bioengineer.org
bioengineer.org

Epigenetic changes in stromal cells drive disease-promoting tissue niches - Bioengineer.org

This work suggests that non-immune stromal cells can hold an epigenetic ‘memory’ that keeps intestinal tissue in a disease-promoting state, which may help explain relapse or incomplete responses to immune-focused...

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TL1A-DR3 Signaling in Inflammatory Bowel Disease: From Pathogenesis to Therapeutic Targeting.
The Kurume medical journal

TL1A-DR3 Signaling in Inflammatory Bowel Disease: From Pathogenesis to Therapeutic Targeting.

TL1A-DR3 is implicated in both inflammation and fibrosis in IBD, so targeting it could address active disease and reduce fibrotic complications that lead to strictures. New TL1A-blocking antibodies are already in...

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Microbiota-derived 4-HPAA alleviates Crohn's disease by stabilizing SIRT1 and reprogramming macrophage immunometabolism.
Apoptosis : an international journal on programmed cell death

Microbiota-derived 4-HPAA alleviates Crohn's disease by stabilizing SIRT1 and reprogramming macrophage immunometabolism.

The study links a polyphenol-rich diet to a specific microbiome change and a microbial metabolite (4-HPAA) that reduced inflammation in mouse models — offering a possible mechanism by which diet could influence Crohn's...

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