Complications

People with IBD are at increased risk of bone loss; this study points to a microbiome-related pathway (A. muciniphila and an IDA metabolite) that might protect bone in an experimental colitis model, which could...

Patients with multiple biologic failures appear more likely to have inflammatory comorbidities (including IBD) and to experience worse dermatology-related quality of life despite similar early skin improvement. That...

PSC co-occurring with celiac disease appears more common than expected and is associated with a high rate of liver complications (including cirrhosis) and frequent coexisting IBD—information that may affect monitoring...

The review suggests NETs are elevated in IBD and that reducing NETs activity helped in animal models—so NETs could be a future therapeutic target and a biomarker of disease severity.

The review proposes S100B as a molecular link connecting enteric glial activation, intestinal barrier dysfunction, and liver/brain inflammation. If confirmed, this could help explain symptom overlap between gut and...

The review compiles trial and real-world safety data for upadacitinib in IBD and highlights monitoring needs and infection risks (notably herpes zoster), which are directly relevant when choosing or managing JAK...

Based on the title and source metadata, this appears to be a case report related to Inflammatory bowel disease and Complications. The original article is from Journal of investigational allergology & clinical immunology.

Based on the title and source metadata, this appears to be a case report related to Crohn's disease, Infliximab, and Anti-TNF. The original article is from Polish archives of internal medicine.

Based on the title and source metadata, this appears to be a case report related to Crohn's disease and Symptoms and flares. The original article is from Clinical and experimental dermatology.

The gut–liver axis links intestinal inflammation to liver disturbances in IBD. This preclinical study suggests a specific oat β‑glucan fraction reduced liver oxidative stress and inflammation in rats with chemically...

The work links a specific transcriptional regulator (GABPA) to STING-driven interferon and inflammatory responses and shows relevance to IBD and SLE patient samples, pointing to a potential new target for therapies aimed...

Fibrostenosing (stricturing) Crohn’s disease is a major cause of complications and surgeries. Early-phase clinical results about a therapy targeting fibrotic strictures could matter to people facing strictures or...

Bright, round objects on stomach CT scans can be mistaken for retained pills or bleeding. For people with Crohn's disease who commonly receive CT enterography and may have bile reflux or duodenal narrowing, this report...

Cure8 could only read part of this source from tradingview.com, so this card uses cautious topic tags instead of a full summary. It is tagged for Crohn's disease, Inflammatory bowel disease, and Ontunisertib.

This study suggests an existing antimalarial drug, artemisinin, may reduce inflammation and improve gut barrier function in a mouse model of ulcerative colitis by targeting CD40 — a pathway relevant to immune-driven gut...

Atypical colitis occurring after rituximab is relevant to patients and clinicians because it may mimic Crohn's disease and require different management; recognizing drug‑associated colitis could affect diagnostic workup...

CDI is a common and serious complication in people hospitalized with IBD. Understanding whether CDI independently increases the risk of death, ICU care, or surgery — or mainly drives longer stays and higher costs — helps...

Based on the title and source metadata, this appears to be a case report related to Ulcerative colitis and Complications. The original article is from Gastroenterologia y hepatologia.

Researchers increasingly implicate innate lymphoid cells in IBD inflammation and mucosal barrier breakdown — findings that could guide future diagnostics or therapies. For patients, this helps explain research directions...

The study identifies MrgprD on colonic macrophages as a driver of pro-inflammatory macrophage polarization and worse acute colitis in mice, highlighting a potential new pathway relevant to human IBD.

This study highlights macrophages — immune cells already suspected in IBD — and identifies MrgprD as a molecular driver in mouse colitis models, suggesting a new potential target that might one day lead to treatments...

Cure8 could only read part of this source from rttnews.com, so this card uses cautious topic tags instead of a full summary. It is tagged for Crohn's disease, Inflammatory bowel disease, and Ontunisertib.

Setons are a common surgical tool to manage draining perianal fistulas in Crohn’s disease by keeping tracts open for drainage and reducing infection. A low-cost, catheter-based seton option could be useful in settings...

Predicting which patients with acute severe ulcerative colitis will need colectomy or will not respond to steroids can guide early treatment decisions. This study shows that important predictors differ between East Asian...

A single‑patient report suggests guselkumab (IL‑23 inhibitor) may control both refractory pyoderma gangrenosum and coexisting Crohn disease when several prior treatments failed.

Interstitial lung disease (ILD) is an underrecognized extraintestinal complication in IBD that in this study was relatively common (12%) and associated with a substantially increased risk of death.

Mothers with chronic diseases such as MS and IBD appear to have higher rates of peripartum mental illness requiring care across serial pregnancies, so awareness and monitoring during and between pregnancies may be...

Circulating glycoprotein signals may help explain how systemic inflammation in IBD interacts with metabolic liver disease (MASLD). If validated, they could improve risk stratification for liver complications beyond...

This press release signals a step toward a new local, regenerative approach for treating complex perianal fistulas—a difficult Crohn’s complication with limited options. If clinical trials proceed, the therapy could add...

The study links macrophage CD38-driven NAD depletion to intestinal inflammation and shows that restoring NAD or blocking CD38 reduced disease in experimental colitis—suggesting a new metabolic target for IBD therapies.

Shorter hospital stay after colorectal surgery can reduce disruption, infection risk, and costs. This review suggests ERAS pathways can shorten length of stay for people with IBD without increasing short-term...

Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease and Complications. The original article is from Inflammatory bowel diseases.

This paper suggests children and teens with ulcerative colitis have higher rates of diagnosed mental disorders and antidepressant use compared with peers, indicating mental-health needs are an important part of pediatric...

Based on the title and source metadata, this appears to be a case report related to Inflammatory bowel disease and Complications. The original article is from Medicina clinica.

Phase angle, an easy-to-measure BIA parameter, was lower in IBD patients with malnutrition and higher disease activity. Detecting malnutrition earlier could matter for patients' strength, healing, and overall outcomes.

The paper links MKL1 to intestinal epithelial repair and shows it is elevated in IBD tissues, suggesting MKL1 helps restore the gut lining after injury — a key process in IBD recovery.

The report highlights a serious drug-related complication (pancytopenia/myelosuppression and hair loss) in a patient treated with azathioprine plus sulfasalazine for ulcerative colitis, suggesting clinicians and patients...

This report describes combined use of upadacitinib and ustekinumab to treat severe, refractory perianal Crohn’s disease in an adolescent — a scenario many patients and caregivers find especially difficult to manage.

The trial suggests starting infliximab early can delay the need for further biologic escalation in children with moderate-to-severe Crohn’s disease, and that stopping anti‑TNF after induction often leads to relapse.

If creeping fat and mesenteric inflammation matter in your Crohn’s disease, this study suggests a new mechanism linking adipocyte autophagy to proinflammatory lipid mediators (oxylipins) and local immune activation —...

Long-term real-world data on filgotinib help patients and clinicians understand how durable benefits and risks are over 2 years, including likelihood of staying on therapy and changes in inflammation markers.

The review suggests baseline corticosteroid use may change how well some advanced UC therapies work, especially IL-23 inhibitors and S1P modulators, which could affect treatment choices and trial reporting.

FibroScan detects liver fibrosis and steatosis that are common and sometimes under-recognized in people with IBD; identifying liver disease earlier could change monitoring or referral decisions, especially for patients...

Cure8 could only read part of this source from American Journal of Therapeutics, so this card uses cautious topic tags instead of a full summary. It is tagged for Ulcerative colitis, Infliximab, and Ustekinumab.

Perianal fistulas in Crohn’s disease are often hard to treat; this review suggests stem cell therapies can produce durable closure for many patients and appear safe over 1–4 years of follow-up.

This study provides real-world data suggesting the oral α4-integrin antagonist carotegrast methyl can improve patient-reported stool frequency and rectal bleeding in many people with ulcerative colitis who did not...

A Meckel diverticulum can present like Crohn’s disease and may be the true cause when IBD treatment fails; identifying it can lead to a surgical cure for symptoms such as anemia and obstruction.

Based on the title and source metadata, this appears to be a case report related to Crohn's disease, Fistula, and Complications. The original article is from Journal of gastrointestinal and liver diseases : JGLD.