Complications

Systemic glucocorticoids used for UC can cause bone loss; identifying early, noninvasive markers could let clinicians detect steroid-induced osteoporosis sooner and intervene to reduce fracture risk.

Perianal fistulas are a common, hard-to-heal complication of Crohn's disease. This review collects current options beyond infliximab and explains where evidence is stronger or still emerging, which can help patients and...

The case links thymic hyperplasia, thyroid autoimmunity, and severe UC with colorectal neoplasia, suggesting possible shared immune dysregulation that might interest patients and clinicians, but it does not support...

Based on the title and source metadata, this appears to be a case report related to Ulcerative colitis, Inflammatory bowel disease, and Complications. The original article is from Canadian Medical Association Journal.

A rare but serious neurological complication (Guillain–Barré syndrome) occurred alongside a severe UC flare after abrupt vedolizumab withdrawal, so people with UC should be aware that sudden neurologic weakness needs...

Patients with IBD who may need dupilumab for another immune condition could benefit from evidence about whether combining dupilumab with IBD biologics or advanced therapies changes infection or healthcare-utilization...

Malnutrition and impaired growth are common at diagnosis in paediatric IBD—especially Crohn’s disease—and identifying these issues early can guide nutrition and treatment planning. Most underweight children in this study...

This study maps a shared transcriptional programme linking inflamed IBD tissue to colorectal cancer pathways, highlighting potential biomarker and prevention targets relevant to the inflammation-to-cancer transition.

Fistula-associated adenocarcinoma is a rare but serious long-term complication of Crohn’s disease that can be missed because symptoms overlap with benign disease. Awareness can prompt timely diagnostic evaluation when...

The study shows pouchitis is a frequent postoperative problem in children after RPC‑IPAA and that many will still require advanced IBD medications, so surgery may not end medical therapy needs.

Atypical HUS is a rare, potentially life-threatening thrombotic microangiopathy that can be triggered by systemic inflammation such as IBD. Early recognition and complement testing can change management and may lead to...

People with IBD often need long-term advanced therapies. Cancer risk concerns commonly influence treatment choices—this review compiles current evidence to help patients and clinicians weigh risks when starting or...

This study compares first‑line vedolizumab versus TNF antagonist strategies in biologic‑naive ulcerative colitis patients over multiple years — information that could affect treatment choice and expectations about...

This review reframes IBD as a systemic disease influenced by gut microbes, metabolism, and immune interactions — which matters because it points toward better ways to stratify patients, monitor disease, and personalize...

This study identifies a fibroblast-ILC3-pDC pathway that may help restrain gut inflammation and appears reduced in IBD tissue, highlighting a new non-immune cell mechanism relevant to disease biology.

The paper identifies a neutrophil-related immune pathway (KARAP → IDO1–kynurenine → AhR → IL-22) that contributes to mucosal inflammation in ulcerative colitis, suggesting a potential new target for research and drug...

Atypical presentations of Crohn's disease (abdominal wall abscess with enterocutaneous fistula) can delay diagnosis and treatment in children. Patients with communication difficulties may be at higher risk for missed or...

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Inflammation Research.

People with Crohn’s disease and prior bowel surgeries may face different risks and trade-offs when choosing prostate cancer treatment. A multidisciplinary, patient-centered approach helped this patient avoid additional...

This study provides real-world evidence about using upadacitinib as a maintenance therapy in children with refractory Crohn’s disease — a group with limited treatment options.

This study compares bloodstream infection risk across commonly used biologics for IBD, which could affect decisions about choosing or monitoring biologic therapy. It also highlights that steroid co-use may increase...

Diet is a modifiable factor many people with IBD try to use to manage symptoms and disease; this review summarizes what is and isn’t supported by current evidence for popular diets and structured nutritional therapies.

Patients and clinicians often face trade-offs when managing overlapping immune-mediated diseases. This report shows how past thromboembolic events and disease remission status can steer therapy away from JAK inhibitors...

Dose increases are common during IBD maintenance and vary a lot by drug and patient profile. Knowing which treatments and patient factors are linked to escalation can help patients and clinicians plan monitoring and...

This pooled analysis compares serious-infection and sepsis risks across advanced therapies used in immune-mediated inflammatory diseases, including IBD. It suggests JAK inhibitors are linked to higher serious-infection...

Depression before an IBD diagnosis was linked to more early treatment escalation and acute-care use after diagnosis. Recognizing preexisting depression could help clinicians identify patients who may benefit from closer...

A simple blood lymphocyte percentage could be a convenient, non-invasive marker to help distinguish endoscopic remission from active disease in both Crohn’s and ulcerative colitis; chemokines CXCL10 and CCL25 may also...

Patients and clinicians often need evidence about whether switching from ustekinumab to an anti‑TNF (infliximab or adalimumab) still gives meaningful clinical responses. This study suggests many patients can respond, but...

Obese patients with FibroScan-detected steatosis in this cohort had a high frequency of colitis and some cases of IBD, dysplasia, and cancer, which could affect screening and symptom evaluation decisions.

Malnutrition was common in this group and linked to lower fistula healing and a higher chance of needing proctectomy or abdominal surgery — outcomes that matter to people with perianal Crohn’s disease.

This study gives real-world 52‑week data on upadacitinib maintenance in children with refractory Crohn's disease, showing meaningful remission rates but also notable adverse events. That balance is important for families...

Preclinical data suggest blocking STAT3 with TTI-101 prevented colitis-associated colorectal tumors in a mouse model and altered tumor-related gene expression and the gut microbiome — findings that could guide future...

Based on the title and source metadata, this appears to be a systematic review or meta analysis related to Inflammatory bowel disease and Research and clinical trials. The original article is from Frontiers in...

Cure8 indexed source-provided abstract text from The Laryngoscope, but this record did not meet the threshold for a full Cure8 brief. It is tagged for Crohn's disease and Complications.

Strictures cause obstructive symptoms and repeat surgery in Crohn’s disease; endoscopic options can relieve obstruction and potentially avoid or postpone surgery for some patients.

A blood biomarker that flags higher risk for complicated Crohn's could help identify people who may need closer monitoring or earlier treatment escalation before clear symptoms or endoscopic inflammation appear.

VEO-IBD often presents with severe, extensive disease and can include monogenic causes and early hepatobiliary complications; knowing common presentations and early management patterns helps families and clinicians plan...

Findings describe how often and when dysplasia recurs after ESD for UC-associated neoplasia, information that can affect decisions about endoscopic treatment versus colectomy and surveillance planning.

The study reports that kaempferol reduced inflammation, fibrosis, and barrier damage in mouse and cell models of colitis — mechanisms directly relevant to IBD progression and symptoms.

People with IBD may be concerned about environmental exposures that could influence inflammation or worsen disease. This review explains why micro- and nanoplastics are biologically plausible contributors but also why...

The study proposes a new immunomodulatory approach—phosphatidylserine liposomes—that reduced inflammation in mouse colitis models and altered monocyte and T-cell responses, which could point toward future therapies for...

Sarcopenia (loss of muscle mass) appears common in people with IBD and is linked to markers of active disease and anemia; identifying it could point to patients who need nutritional or rehabilitation support.

A plant-derived polysaccharide improved inflammation, gut barrier markers, and metabolic measures in a mouse model of diabetes-linked ulcerative colitis — findings that could point to new research directions for...

Antibiotics can cause microbiome injury that increases risk of C. difficile and may worsen long-term health issues; identifying ways to protect the gut microbiome during antibiotic use could be especially relevant for...

Long-term results suggest endoscopic approaches—especially balloon dilatation—help many people with Crohn’s strictures avoid surgery and have fewer severe complications compared with surgical treatment.

Cocaine use can trigger severe GI problems that mimic common surgical and inflammatory conditions; recognizing the link can speed diagnosis and management. Most published evidence is low-level (case reports/series), so...

Based on the title and source metadata, this appears to be a case report related to Complications. The original article is from Clinical case reports.

Undernutrition and lean-mass loss are common and harmful in people with IBD. If dietary strategies can prevent weight and muscle loss and shift the gut microbiota toward SCFA producers, that could be relevant to...