Fistulas, strictures, obstruction, anemia, cancer risk, extraintestinal symptoms, and related complications.
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Perianal fistulas are a common and debilitating complication of Crohn’s disease that often need medical and surgical care. A Phase 3 trial reporting improved fistula remission with an IL-23–targeting therapy could offer...
Perianal Crohn’s disease causes major symptoms and affects long-term outcomes; understanding surgical options and the role of combined medical–surgical care can help patients and clinicians plan treatment. The review...
Long-term control of inflammation and healing of draining fistulas are important for people with Crohn’s disease; these FORTIFY OLE analyses suggest durable benefit with risankizumab in responders through several years...
This study describes how often people newly diagnosed with IBD go on biologic or JAK inhibitor therapy and what happened to them over five years — including hospital visits and surgery — which helps set expectations for...
People with ulcerative colitis can rarely develop inflammatory complications outside the gut, including central nervous system vasculitis that can look like a brain tumor. Recognizing this can change diagnosis and...
Patients with PsA and clinicians choosing long‑term biologic therapy may care about both durability of PsA control and safety signals for related inflammatory conditions like IBD and uveitis. This analysis reports...
Cure8 found this source from cureus.com, but the page could not be read reliably yet. It is tagged for Crohn's disease and Complications. Open the original article for the full details.
MRE is a noninvasive imaging test commonly used to evaluate small-bowel Crohn’s disease, especially when disease is beyond the reach of endoscopy or when repeated follow-up imaging is needed. It helps detect...
AMNs are rare but can be malignant and may mimic UC flares or appendicitis, which can delay diagnosis. For people with long-standing UC, awareness may prompt appropriate imaging and surgical referral.
Based on the title and source metadata, this appears to be a systematic review or meta analysis related to Ulcerative colitis, Inflammatory bowel disease, and Complications. The original article is from Asian Journal of...
The study suggests pulmonary nodules are more common in people with Crohn’s disease and that age and certain medications (not disease phenotype) may better predict nodule burden — information that could influence how...
Preclinical evidence suggests certain dietary flavonoids may protect the gut barrier, reshape the microbiome, and reduce neuroinflammation, which could be relevant to colitis-linked cognitive problems. This points to...
Microbiological differences in Crohn’s-related abscesses could affect empirical antibiotic choices and highlight the importance of culture-directed therapy, especially in patients on immunosuppression who showed higher...
Enteric hyperoxaluria increases risk of calcium oxalate kidney stones and kidney injury. Knowing how common EH is in Crohn's disease and after bariatric surgery helps identify who might benefit from screening and...
The story highlights how Crohn’s disease can require ongoing treatment and how legal and travel problems can affect access to care. It may be relevant to people with IBD who use or consider cannabis/CBD products for...
Internal fistulae can be clinically silent yet serious in long-standing Crohn's disease. Early cross-sectional imaging detected rare gastrocolic and duodenocolic fistulae in this patient, and elective combined surgery...
A rapidly growing abdominal mass or unexplained systemic decline in someone with Crohn's disease may represent a rare malignancy (plasmablastic neoplasm) rather than infection or a disease flare; prompt biopsy is...
This study reports real-world short-term outcomes after colectomy for IBD at a tertiary New Zealand centre, including complication rates and how often restorative surgery (ileal pouch) was later performed—information...
Food insecurity was linked with higher odds of having IBD and other GI conditions in a large U.S. survey, and many affected people lacked benefits or cancer screening. This matters because access to sufficient nutritious...
Faecal urgency is a frequent, disabling symptom in Crohn's disease that was common in this cohort and tied to poorer quality of life, mental-health burden, and more healthcare use over one year.
Pulmonary nodules appear more frequently in people with Crohn’s disease and have distinct patterns over time. Knowing which factors predict nodule burden can help clinicians prioritize monitoring and interpret chest...
Rising IBD incidence and prevalence in Asia mean more people will need long-term care, specialist services, and health-system planning. Understanding regional trends helps patients and policymakers anticipate resource...
Perianal fistulas cause significant morbidity and often need both medical and surgical treatments. Newer drug options and updated guideline support earlier use of advanced therapies, which may improve healing and reduce...
Perianal fistulizing Crohn's often causes significant symptoms and requires both medical and surgical approaches. Newer biologics and JAK inhibitors expand treatment options and guidelines increasingly support earlier...
Extraintestinal problems are common in IBD and can cause significant symptoms and treatment needs beyond the bowel. Knowing their frequency helps patients and clinicians prioritize screening and multidisciplinary care.
If findings translate beyond mice, exposure to titanium dioxide during pregnancy could influence offspring gut barrier, microbiota, and susceptibility to inflammatory colitis — a potential public-health concern for...
Based on the title and source metadata, this appears to be a case report related to Crohn's disease, Inflammatory bowel disease, and Pain. The original article is from Gut.
This study gives real-world comparative data on two biologic options (vedolizumab vs anti-TNFα) used early in the treatment course for Crohn’s disease, which may help patients and clinicians weigh effectiveness and...
People with ulcerative colitis face long-term health risks beyond the gut. This study suggests that getting a colectomy early after diagnosis might be linked to lower long-term risk of cardiovascular disease and type 2...
This study links a neutrophil protein (ANXA3) to both ulcerative colitis and ischaemic stroke and suggests a compound (ginsenoside Rb1) can bind ANXA3 and reduce neutrophil hyperactivation in lab tests — a potential...
The work highlights molecular differences between PSC-UC and typical UC that could help explain higher colorectal cancer risk in PSC-UC and suggests candidate miRNA biomarkers (eg, miR-155) for further study.
Based on the title and source metadata, this appears to be a systematic review or meta analysis related to Crohn's disease, Inflammatory bowel disease, and Microbiome. The original article is from Immunity, inflammation...
The paper suggests a molecular link (RHBDF2–ADAM17–TNFα) between ulcerative colitis and blood–brain barrier disruption, which could explain some neurological comorbidities of UC and identify targets for future therapies.
Transmural healing on CT enterography was associated with fewer hospitalizations over long follow-up, which could matter for long-term disease management and monitoring strategies in Crohn’s disease.
Accurate, radiation-free imaging at the point of care can speed diagnosis and management of strictures, abscesses, and fistulas in Crohn’s disease. Improved ultrasound techniques may help determine who needs surgery or...
Perianal fistulas are common and burdensome in Crohn’s disease; this large multicenter Korean study quantifies high rates of complex fistulas, frequent recurrence, and suggests biologic therapy is associated with fewer...
Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Complications. The original article is from Crohn's & colitis 360.
The molecular interaction between acetylation and ubiquitination on NLRP3 and GSDMD could help explain mechanisms of inflammatory cell death relevant to UC and point to new biomarker or therapeutic targets, but direct...
Based on the title and source metadata, this appears to be a case report related to Ulcerative colitis, Anemia, and Complications. The original article is from Medicina clinica.
Based on the title and source metadata, this appears to be a case report related to Crohn's disease, Inflammatory bowel disease, and Infliximab. The original article is from Journal of Medical Case Reports.
Postoperative pain control choices after ileocecectomy could affect Crohn's flare risk and opioid exposure. A pediatric center-level analysis found no association between ketorolac and flares and suggested reduced opioid...
For people with UC who do not respond to tacrolimus, adding infliximab may induce remission and reduce the short-term need for colectomy. The findings point to a potential rescue strategy and an option to transition to...
Persistent bowel symptoms can signal a range of conditions, including rare cancers; prompt evaluation helps ensure appropriate diagnosis and treatment. The story highlights symptom overlap between Crohn’s disease and...
The study identifies and functionally validates a new STXBP3 variant that likely causes VEOIBD with immunodeficiency, which can help explain disease in affected infants and inform genetic counseling and further research.
Crohn's is becoming more common among younger Americans and long-term uncontrolled inflammation raises colorectal cancer risk. Understanding possible lifestyle and medical factors can help patients and clinicians focus...
This project explores how CD74 in intestinal stem cells and Paneth cells helps control mucosal immune responses and epithelial repair — processes directly relevant to IBD pathogenesis and recovery.
People with IBD are at increased risk of bone loss; this study points to a microbiome-related pathway (A. muciniphila and an IDA metabolite) that might protect bone in an experimental colitis model, which could...
Patients with multiple biologic failures appear more likely to have inflammatory comorbidities (including IBD) and to experience worse dermatology-related quality of life despite similar early skin improvement. That...
