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Procedures and surgery

Resection, ostomy, J-pouch, strictureplasty, fistula, abscess, and other procedure-related updates.

Page 2 of 11 · 488 articles

Frequency and Risk Factors for Difficult-to-Treat Inflammatory Bowel Disease among Patients Receiving Advanced Therapies in a Korean Tertiary-Care Cohort.
Gut and liver

Frequency and Risk Factors for Difficult-to-Treat Inflammatory Bowel Disease among Patients Receiving Advanced Therapies in a Korean Tertiary-Care Cohort.

The study suggests that about one-quarter of IBD patients treated with advanced therapies develop difficult-to-treat disease, and identifies timing of therapy, age, and specific therapy choice as predictors.

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Endoscopic intralesional platelet-rich plasma (PRP) injection after balloon dilation for colonic Crohn's disease strictures: a pilot study
Springer Science and Business Media LLC

Endoscopic intralesional platelet-rich plasma (PRP) injection after balloon dilation for colonic Crohn's disease strictures: a pilot study

Patients and clinicians exploring new, less-invasive options for fibrostenotic colonic Crohn's disease may be interested because this study reports that intralesional PRP after balloon dilation is feasible and appears...

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Elective combined surgical management of concurrent gastrocolic and duodenocolic fistulae in longstanding Crohn's disease.
Clinical journal of gastroenterology

Elective combined surgical management of concurrent gastrocolic and duodenocolic fistulae in longstanding Crohn's disease.

Internal fistulae can be clinically silent yet serious in long-standing Crohn's disease. Early cross-sectional imaging detected rare gastrocolic and duodenocolic fistulae in this patient, and elective combined surgery...

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A Giant Intra-Abdominal Plasmablastic Neoplasm Favoring Lymphoma Mimicking an Exacerbation of Severe Fistulizing Crohn's Disease: A Case Report.
The American journal of case reports

A Giant Intra-Abdominal Plasmablastic Neoplasm Favoring Lymphoma Mimicking an Exacerbation of Severe Fistulizing Crohn's Disease: A Case Report.

A rapidly growing abdominal mass or unexplained systemic decline in someone with Crohn's disease may represent a rare malignancy (plasmablastic neoplasm) rather than infection or a disease flare; prompt biopsy is...

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Contemporary outcomes and restorative pathways following colectomy for inflammatory bowel disease: a tertiary centre cohort from Aotearoa New Zealand.
The New Zealand medical journal

Contemporary outcomes and restorative pathways following colectomy for inflammatory bowel disease: a tertiary centre cohort from Aotearoa New Zealand.

This study reports real-world short-term outcomes after colectomy for IBD at a tertiary New Zealand centre, including complication rates and how often restorative surgery (ileal pouch) was later performed—information...

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Agomab to Present STENOVA Open-Label Extension Data of Ontunisertib at UEG Week ...

Patients with fibrostenosing Crohn’s disease face progressive strictures and limited targeted treatments; data from STENOVA’s OLE and the planned NOV‑ERA trial could advance therapies that target both inflammation and...

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Association of narrow pelvis and body composition with anastomotic stricture following total proctocolectomy with ileal pouch–anal anastomosis for ulcerative colitis
BMC Surgery

Association of narrow pelvis and body composition with anastomotic stricture following total proctocolectomy with ileal pouch–anal anastomosis for ulcerative colitis

Anastomotic strictures after TPC–IPAA can impair bowel function and quality of life; identifying preoperative pelvic and body-composition risk factors could help tailor surgical planning or follow-up.

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Early Colectomy and Long-Term Risk of Cardiometabolic Disease in Ulcerative Colitis: A Nationwide Cohort Study
American Journal of Gastroenterology

Early Colectomy and Long-Term Risk of Cardiometabolic Disease in Ulcerative Colitis: A Nationwide Cohort Study

People with ulcerative colitis face long-term health risks beyond the gut. This study suggests that getting a colectomy early after diagnosis might be linked to lower long-term risk of cardiovascular disease and type 2...

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Beyond Crohn's disease: ileal Kaposi sarcoma in a transplant recipient presenting with subocclusive symptoms. A concomitant diagnosis of Crohn's disease and ileal Kaposi sarcoma.
Minerva gastroenterology

Beyond Crohn's disease: ileal Kaposi sarcoma in a transplant recipient presenting with subocclusive symptoms. A concomitant diagnosis of Crohn's disease and ileal Kaposi sarcoma.

Immunosuppressed patients with refractory or atypical Crohn’s symptoms may rarely have intestinal Kaposi sarcoma, which can change management. Recognizing this possibility could alter the need for surgery versus systemic...

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Disease characteristics, outcomes, and poor prognostic factors of perianal fistula in Korean patients with Crohn's disease: a multicenter, retrospective observational study.
Intestinal research

Disease characteristics, outcomes, and poor prognostic factors of perianal fistula in Korean patients with Crohn's disease: a multicenter, retrospective observational study.

Perianal fistulas are common and burdensome in Crohn’s disease; this large multicenter Korean study quantifies high rates of complex fistulas, frequent recurrence, and suggests biologic therapy is associated with fewer...

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Post-Operative Ketorolac in Children After Crohn's Ileocecectomy.
Pediatric surgery international

Post-Operative Ketorolac in Children After Crohn's Ileocecectomy.

Postoperative pain control choices after ileocecectomy could affect Crohn's flare risk and opioid exposure. A pediatric center-level analysis found no association between ketorolac and flares and suggested reduced opioid...

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Intraoperative endoscopic stricturotomy combined with strictureplasty for multiple small bowel strictures in Crohn’s disease: a pilot case series
Surgical Endoscopy

Intraoperative endoscopic stricturotomy combined with strictureplasty for multiple small bowel strictures in Crohn’s disease: a pilot case series

Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease, Inflammatory bowel disease, and Strictureplasty. The original article is from Surgical Endoscopy.

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Feasibility of a Wireless Thermal Capsule Endoscopy to Detect Gastrointestinal Thermal Variance
ClinicalTrials.gov

Feasibility of a Wireless Thermal Capsule Endoscopy to Detect Gastrointestinal Thermal Variance

Researchers are testing a new swallowable thermal capsule that could eventually help detect temperature changes from GI inflammation. For people with Crohn’s disease or IBD, a safe, noninvasive way to sense inflammatory...

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Patient outcomes and healthcare utilisation following implementation of an advanced therapy care pathway for inflammatory bowel disease: a multicentre, prospective quasi-experimental preimplementation/postimplementation study in the Netherlands.
BMJ open gastroenterology

Patient outcomes and healthcare utilisation following implementation of an advanced therapy care pathway for inflammatory bowel disease: a multicentre, prospective quasi-experimental preimplementation/postimplementation study in the Netherlands.

Standardised care pathways may reduce hospital admissions and help health systems manage the burden of IBD without worsening patient-reported disease control.

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Development and Evaluation of an Eudragit-Coated Colon-Targeted Delivery System for Myrica esculenta in Ulcerative Colitis.
Current pharmaceutical biotechnology

Development and Evaluation of an Eudragit-Coated Colon-Targeted Delivery System for Myrica esculenta in Ulcerative Colitis.

A colon-targeted delivery system could allow an anti-inflammatory plant extract (Myrica esculenta) to reach the colon with minimal systemic exposure, which may be relevant for developing localized treatments for...

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Colonoscopic Intubation of the Appendix Through a Patulous Appendiceal Orifice in Ulcerative Colitis.
Internal medicine (Tokyo, Japan)

Colonoscopic Intubation of the Appendix Through a Patulous Appendiceal Orifice in Ulcerative Colitis.

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Procedures and surgery. The original article is from Internal medicine (Tokyo,...

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Agomab Reports Positive Topline Data from STENOVA Open-Label Extension Study of Ontunisertib in Fibrostenosing Crohn's Disease

Patients with fibrostenosing Crohn’s disease have limited treatment options for the fibrotic strictures that can lead to procedures and surgery. These OLE findings suggest ontunisertib may be safe long-term and could...

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Inside Biotech: NeuroScientific appoints Southern Star Research to advance Phase 2 Crohn’s disease trial
au.finance.yahoo.com

Inside Biotech: NeuroScientific appoints Southern Star Research to advance Phase 2 Crohn’s disease trial

A new Phase 2 study of StemSmart™ could expand treatment options for patients with refractory or fistulising Crohn’s disease if later trials confirm safety and benefit. Appointment of a CRO is an early but important step...

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EVerZom successfully completes CTA-enabling preclinical studies of EVerGel™ required to support a clinical trial application
markets.businessinsider.com

EVerZom successfully completes CTA-enabling preclinical studies of EVerGel™ required to support a clinical trial application

This press release signals a step toward a new local, regenerative approach for treating complex perianal fistulas—a difficult Crohn’s complication with limited options. If clinical trials proceed, the therapy could add...

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Enhanced recovery after colorectal surgery in patients with inflammatory bowel disease to reduce hospital length of stay: A systematic review and meta-analysis.
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

Enhanced recovery after colorectal surgery in patients with inflammatory bowel disease to reduce hospital length of stay: A systematic review and meta-analysis.

Shorter hospital stay after colorectal surgery can reduce disruption, infection risk, and costs. This review suggests ERAS pathways can shorten length of stay for people with IBD without increasing short-term...

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Health Related Quality of Life in Patients with Inflammatory Bowel Disease in Department of Gastroenterology of Dhaka Medical College Hospital: An Observational Study.
Mymensingh medical journal : MMJ

Health Related Quality of Life in Patients with Inflammatory Bowel Disease in Department of Gastroenterology of Dhaka Medical College Hospital: An Observational Study.

Quality of life is often substantially affected in IBD; this study identifies active disease, greater severity, prior surgery, and stricturing Crohn's disease as factors linked to lower HRQoL, highlighting areas...

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Engineering a Built-in Piezoelectric Electron Sponge in Swallow Nanozyme for Inflammatory Bowel Disease Therapy.
Small (Weinheim an der Bergstrasse, Germany)

Engineering a Built-in Piezoelectric Electron Sponge in Swallow Nanozyme for Inflammatory Bowel Disease Therapy.

The article reports a new oral nanozyme that combines imaging and ROS-scavenging therapy aimed at IBD lesions—an early-stage approach that could one day enable targeted, noninvasive treatment and lesion tracking.

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