Condition

Crohn's disease

Crohn's disease news across medications, symptoms, tests, procedures, complications, research, access, and daily life.

Page 32 of 53 · 2520 articles

A Specific Probiotic in thE MOdulation of Gut Microbiota of patieNts With Mild-to-modErate Ulcerative Colitis
ClinicalTrials.gov

A Specific Probiotic in thE MOdulation of Gut Microbiota of patieNts With Mild-to-modErate Ulcerative Colitis

This trial is testing whether a rectally delivered probiotic can change the gut microbiome and promote mucosal healing in people with mild-to-moderate ulcerative colitis (and includes some Crohn's patients). If...

Read Summary
EXPRESS: Inflammatory bowel disease and cardiovascular risk: A meta-analysis.
Journal of investigative medicine : the official publication of the American Federation for Clinical Research

EXPRESS: Inflammatory bowel disease and cardiovascular risk: A meta-analysis.

This meta-analysis suggests people with IBD face higher risks of major cardiovascular events (heart attack, ischemic heart disease, ischemic stroke), which may matter for monitoring and preventive care. Higher risk...

Read Summary
Effects of cuproptosis and its application in inflammatory bowel disease (Review).
International journal of molecular medicine

Effects of cuproptosis and its application in inflammatory bowel disease (Review).

Researchers report links between copper-driven cell death pathways and IBD biology; identifying cuproptosis-related biomarkers or drugs could open new diagnostic or therapeutic avenues for people with Crohn's disease or...

Read Summary
The Potential Role of the Mediterranean Diet on Clinical Outcomes in Patients with Inflammatory Bowel Disease: A Systematic Review.
Clinical nutrition ESPEN

The Potential Role of the Mediterranean Diet on Clinical Outcomes in Patients with Inflammatory Bowel Disease: A Systematic Review.

Diet is a modifiable factor many people with IBD try to use to feel better. This review summarizes current evidence that a Mediterranean-style eating pattern may help quality of life and is linked to lower inflammation...

Read Summary
Emerging role of intestinal ultrasound in detecting postoperative recurrence in Crohn's disease.
Gastroenterology report

Emerging role of intestinal ultrasound in detecting postoperative recurrence in Crohn's disease.

Noninvasive tools that reliably detect postoperative recurrence could reduce the need for frequent invasive endoscopy and help target earlier intervention for people with Crohn's disease after surgery.

Read Summary
Blood heavy metal and trace element levels in newly diagnosed cases of inflammatory bowel disease.
Pakistan journal of medical sciences

Blood heavy metal and trace element levels in newly diagnosed cases of inflammatory bowel disease.

The study suggests nickel accumulation and iron deficiency may be linked with more severe IBD. If confirmed, blood metal and micronutrient levels could help researchers understand disease mechanisms and guide nutritional...

Read Summary
Microbial predictors of sustained clinical remission following the Crohn's disease exclusion diet in adults and microbiome shifts toward healthy pediatric controls.
Crohn's & colitis 360

Microbial predictors of sustained clinical remission following the Crohn's disease exclusion diet in adults and microbiome shifts toward healthy pediatric controls.

If you or your clinician are considering dietary therapy like the CDED for Crohn's disease, microbiome features at baseline may influence who achieves sustained remission. Understanding these links could help personalize...

Read Summary
Reactive Therapeutic Drug Monitoring Guides Optimal Management of Adalimumab Failure in Pediatric Crohn's Disease: A Real-World Single-Center Experience.
Pediatric gastroenterology, hepatology & nutrition

Reactive Therapeutic Drug Monitoring Guides Optimal Management of Adalimumab Failure in Pediatric Crohn's Disease: A Real-World Single-Center Experience.

Reactive TDM can help determine why a child with Crohn's disease is losing response to adalimumab and guide whether to escalate dose or switch biologics, which affects short-term management decisions.

Read Summary
Spatial genetic mapping links shared inflammatory bowel disease liability to adult immune-epithelial lesion contexts.
Frontiers in immunology

Spatial genetic mapping links shared inflammatory bowel disease liability to adult immune-epithelial lesion contexts.

Links between IBD genetic risk and specific adult tissue lesion contexts help researchers understand which cell types and tissue programs may mediate inherited susceptibility. That can guide future biomarker and...

Read Summary
Effectiveness and Safety of Risankizumab in Crohn Disease After Failure of a First Line of Advanced Therapy: A Long-Term, Real-Life Study.
American journal of therapeutics

Effectiveness and Safety of Risankizumab in Crohn Disease After Failure of a First Line of Advanced Therapy: A Long-Term, Real-Life Study.

This real-world, multicenter study suggests risankizumab can induce clinical and steroid-free remission and mucosal healing in many patients with Crohn disease who previously failed advanced therapies, which may be...

Read Summary
Antibiotic Class-Specific Effects on Inflammatory Bowel Disease: Microbiome Disruption, Risk, and Recovery
International Journal of Molecular Sciences

Antibiotic Class-Specific Effects on Inflammatory Bowel Disease: Microbiome Disruption, Risk, and Recovery

Antibiotics can change the gut microbiome in ways that may raise IBD risk or worsen disease for some people. Knowing which antibiotic classes and approaches may be less harmful could help patients and clinicians reduce...

Read Summary
Developing a Self-Management Intervention to Improve Health Outcomes for Patients With Inflammatory Bowel Disease
ClinicalTrials.gov

Developing a Self-Management Intervention to Improve Health Outcomes for Patients With Inflammatory Bowel Disease

Digital self-management programs could help people with active IBD build skills to manage symptoms and quality of life between clinic visits. This trial tests whether such a program is feasible, acceptable, and practical...

Read Summary
Subcutaneous infliximab in the treatment of patients with perianal fistulizing Crohn's disease: current evidence and emerging roles.
Therapeutic advances in gastroenterology

Subcutaneous infliximab in the treatment of patients with perianal fistulizing Crohn's disease: current evidence and emerging roles.

Perianal fistulizing Crohn's disease is a disabling complication; a subcutaneous form of infliximab could lower treatment burden and expand options if its effectiveness and safety in this specific setting are confirmed.

Read Summary
Patient Preferences for Inflammatory Bowel Disease Treatment: Results from a Global Survey Conducted in Partnership with the European Federation of Crohn’s & Ulcerative Colitis Associations
The Patient - Patient-Centered Outcomes Research

Patient Preferences for Inflammatory Bowel Disease Treatment: Results from a Global Survey Conducted in Partnership with the European Federation of Crohn’s & Ulcerative Colitis Associations

This global survey shows that people with IBD prioritize symptom relief and psychological well-being over treatment features like administration route or speed of onset. That matters for shared decision-making, trial...

Read Summary
Reduced fecal GP2 levels in ulcerative colitis associate with inflammatory activity and microbial composition.
Clinica chimica acta; international journal of clinical chemistry

Reduced fecal GP2 levels in ulcerative colitis associate with inflammatory activity and microbial composition.

If fecal GP2 reliably reflects UC activity and microbial changes, it could become a noninvasive marker to track inflammation or to study disease mechanisms that differ between UC and CD.

Read Summary
Association between life satisfaction and selected socio-demographic factors and social and professional activity - a comparative study between patients with Crohn's disease and patients with ulcerative colitis.
Przeglad gastroenterologiczny

Association between life satisfaction and selected socio-demographic factors and social and professional activity - a comparative study between patients with Crohn's disease and patients with ulcerative colitis.

Life satisfaction and social/work impacts are central to daily functioning for people with IBD. Knowing which social factors relate to lower satisfaction can help patients, caregivers, and clinicians spot who may need...

Read Summary
Remission duration according to dietary adherence in paediatric mild to moderate Crohn's disease treated with CDED + PEN.
Przeglad gastroenterologiczny

Remission duration according to dietary adherence in paediatric mild to moderate Crohn's disease treated with CDED + PEN.

Dietary therapy (CDED + PEN) was associated with longer remission when families adhered well; since adherence varies, support from a dietitian matters for keeping children in remission.

Read Summary
Symptom Management Experiences of People Living With Crohn's Disease Through a Journey Map: A Qualitative Study.
Journal of clinical nursing

Symptom Management Experiences of People Living With Crohn's Disease Through a Journey Map: A Qualitative Study.

A patient-centered journey map identifies changing symptom, psychological, and social needs at different stages of Crohn's disease. That can help clinicians and care teams target education, mental-health support, and...

Read Summary
Subcutaneous infliximab in pediatric inflammatory bowel disease: Sustained remission, predictable pharmacokinetics, and real-world US implementation.
Journal of pediatric gastroenterology and nutrition

Subcutaneous infliximab in pediatric inflammatory bowel disease: Sustained remission, predictable pharmacokinetics, and real-world US implementation.

Subcutaneous infliximab could offer children with IBD a more convenient dosing route with higher, steadier drug levels while maintaining remission. Insurance and labeling barriers affected access in this US cohort.

Read Summary
A Phase 2a Safety and Efficacy Open-Label Study of Tulisokibart (MK-7240/PRA023) in Participants With Moderately to Severely Active Crohn's Disease (MK-7240-006)
ClinicalTrials.gov

A Phase 2a Safety and Efficacy Open-Label Study of Tulisokibart (MK-7240/PRA023) in Participants With Moderately to Severely Active Crohn's Disease (MK-7240-006)

This Phase 2a trial tested a new investigational drug, tulisokibart, in people with moderately to severely active Crohn’s disease who have not done well on prior therapies — so patients and clinicians watching new...

Read Summary
Characterization of Colorectal Dysplasic Lesions and Stratification of Their Evolving Risk in Inflammatory Bowel Disease Patients: a Prospective, Observational and Multicenter Study
ClinicalTrials.gov

Characterization of Colorectal Dysplasic Lesions and Stratification of Their Evolving Risk in Inflammatory Bowel Disease Patients: a Prospective, Observational and Multicenter Study

The study will prospectively evaluate how often dysplasia occurs, how lesions look and behave after endoscopic resection, and what factors predict local or distant recurrence—information that could change surveillance...

Read Summary
Intestinal ultrasound for the detection of postoperative recurrence in Crohn's disease: a systematic review and meta-analysis.
Journal of Crohn's & colitis

Intestinal ultrasound for the detection of postoperative recurrence in Crohn's disease: a systematic review and meta-analysis.

Detecting Crohn’s recurrence after bowel surgery is important because recurrence can occur without symptoms. A reliable non-invasive test like intestinal ultrasound could reduce the need for repeated colonoscopies and...

Read Summary
Corticosteroid-sparing effects of risankizumab versus ustekinumab in patients with moderately to severely active Crohn's disease: post hoc results from the phase 3b SEQUENCE trial.
Journal of Crohn's & colitis

Corticosteroid-sparing effects of risankizumab versus ustekinumab in patients with moderately to severely active Crohn's disease: post hoc results from the phase 3b SEQUENCE trial.

For people with moderate–severe Crohn’s disease who failed anti‑TNF drugs, this trial suggests risankizumab may achieve higher corticosteroid‑free clinical and endoscopic remission than ustekinumab, which could mean...

Read Summary