Fistulas, strictures, obstruction, anemia, cancer risk, extraintestinal symptoms, and related complications.
Page 9 of 20 · 922 articles
The study reports a newly discovered class of marine-derived meroterpenoids and identifies a lead compound that reduced inflammatory markers and improved colitis in mice, which could eventually inform new drug...
Patients with UC who appear healed on endoscopy can still relapse; a biopsy-based model could help separate lower- and higher-risk patients and guide monitoring or research enrollment.
The study explores how gut inflammation might influence liver autoimmune disease, which is relevant because people with IBD can have associated autoimmune cholangitis conditions. Understanding immune and metabolic links...
The work searches for shared blood-based gene signatures and biomarkers across HLA-B27–linked diseases (including Crohn’s disease and ulcerative colitis), which could point to common mechanisms or cross-disease...
Clostridium difficile infection is an important and potentially serious complication in ulcerative colitis. A blood‑marker–based risk model could help identify higher‑risk patients noninvasively so clinicians can...
Corticosteroid use during IBD treatment periods was associated with higher rates of serious infections across drug classes and age groups, which may affect decisions about steroid use and infection-prevention planning.
People with IBD have higher risk of several GI and hepatobiliary cancers; imaging is an important complement to endoscopic surveillance for detecting cancers that may be transmural or outside endoscopic reach.
The review aggregates published instances where combining two advanced immunomodulators was followed by improvement in pyoderma gangrenosum, a serious skin complication often seen in people with IBD. However, the...
Cure8 found this source from springermedicine.com, but the page could not be read reliably yet. It is tagged for Crohn's disease and Complications. Open the original article for the full details.
Smoking is a known risk factor for Crohn’s recurrence after bowel surgery. This study suggests newer products marketed as potentially safer (HNBT and e-cigarettes) were also linked to higher postoperative endoscopic...
PG is often linked with IBD and other systemic conditions, so approaches that treat the underlying comorbidity can improve ulcer healing and lower relapse risk. Patients with IBD who develop PG may benefit from therapies...
Cure8 found this source from Journal of investigative medicine : the official publication of the American Federation for Clinical Research, but the page could not be read reliably yet. It is tagged for Inflammatory bowel...
Cure8 could only read part of this source from Pensoft Publishers, so this card uses cautious topic tags instead of a full summary. It is tagged for Ulcerative colitis, Inflammatory bowel disease, and Complications.
People with IBD who take long-term corticosteroids may have multiple overlapping risks for venous thromboembolism (prothrombotic effects of steroids, steroid-induced osteoporosis and fractures, and immobilization).
Cure8 could only read part of this source from Pensoft Publishers, so this card uses cautious topic tags instead of a full summary. It is tagged for Ulcerative colitis, Inflammatory bowel disease, and Complications.
IBD can cause cognitive and neurological symptoms. This preclinical study suggests a flavonoid-rich Chrysanthemum extract reduced colitis and related cognitive deficits in mice by changing the gut microbiota and...
Perianal fistulas are a common and often challenging complication of Crohn’s disease. This surgical series provides outcome data on draining seton treatment that may help patients and clinicians understand typical...
This case shows that upadacitinib, a JAK inhibitor used for refractory IBD, can cause severe anemia in rare cases but that dose reduction (rather than permanent discontinuation) may reversibly restore blood counts while...
People with IBD and their clinicians may want to be aware of possible higher rates of some non-gastrointestinal cancers (thyroid, kidney, prostate) and of factors linked to higher risk such as long-term steroid use,...
The study identifies abnormal epithelial cell–death signaling that persists despite current therapies and may help explain why many people with IBD relapse. If validated, these pathways could point to new biomarkers or...
If you have overweight or obesity, this study suggests measurable blood proteins linked to inflammation may be associated with higher future risk of ulcerative colitis. Identifying such markers could help research on...
Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Complications. The original article is from Expert Review of Clinical Immunology.
Black women with Crohn’s may face higher risk of delayed diagnosis, hospitalization, surgery, and complications such as abscesses, infertility, and bone loss — issues that affect treatment choices and quality of life.
This single case shows that bedside ultrasound can detect serious abdominal problems (intussusception, ischemia) early in people with IBD even when initial vitals and labs look normal.
Pathology after fecal diversion can look like active IBD, which affects diagnosis and management of the diverted rectum. This study helps clarify when changes likely reflect diversion alone versus persistent inflammatory...
Environmental cadmium exposure may alter the gut microbiome’s metabolites (oleic acid) and worsen colitis in mice via FFAR4-linked inflammatory pathways. If similar mechanisms operate in people, this could point to new...
PSC frequently occurs with IBD and has unclear origins; understanding a shared glandular mechanism could help explain the link and point to new research targets relevant to both liver and colon disease.
Achieving histologic or biochemical remission in addition to clinical and endoscopic remission was associated with substantially lower relapse risk in ulcerative colitis across multiple follow-up intervals, suggesting...
The study identifies ABTB1 as a regulator that limits STAT3-driven Th17 differentiation and reduces severity in a mouse colitis model, suggesting a new molecular pathway relevant to IBD inflammation and a potential...
Research linking ETBF to intestinal inflammation and colorectal cancer suggests better detection and targeted therapies for this microbe could eventually affect IBD management and cancer risk assessment.
Nutrition during acute severe ulcerative colitis matters because patients can become rapidly nutritionally fragile, and appropriate feeding and monitoring can affect recovery, complications, and readiness for surgery....
Cardiovascular disease is an important nonintestinal complication for people with IBD; knowing if heart failure risk differs by IBD type could influence monitoring and care planning.
Fistulizing Crohn’s disease is a major complication where durable structural repair is hard to achieve. Regenerative cell-sheet approaches aim to rebuild tissue architecture rather than only suppress inflammation, which...
Patients diagnosed with IBD during or shortly after emergency hospital care had substantially worse 1-year outcomes in this large, population-based analysis — highlighting that late or emergency presentation is linked to...
CDI is a serious infection that raises the risk of death for people with IBD. This study shows mortality linked to IBD+CDI changed over the last 25 years and that racial, geographic, and urban–rural disparities...
PSC is closely linked with IBD (especially ulcerative colitis); understanding mechanisms that damage bile ducts could point to new future therapies or biomarkers.
This study suggests a new, compact DNA-methylation biomarker that identifies accelerated aging in the colon linked to chronic inflammation (IBD) and pre-cancerous conditions. Such biomarkers could eventually help...
The study suggests that modifiable early-life factors (feeding, antibiotic exposure, activity, BMI, smoke exposure, delivery mode, diet) may influence the later risk of IBD, especially Crohn's disease, which could be...
A validated claims-based algorithm could enable larger, more efficient studies of fibrostenosis in Crohn’s disease using real-world data — helping researchers and clinicians better measure how often stricturing...
The study reports an experimental coating that both protects a probiotic and provides antioxidant, anti-inflammatory effects in a mouse colitis model—an approach that, if validated in humans, could improve probiotic...
A JAK inhibitor (upadacitinib) used for moderate–severe ulcerative colitis can cause neutropenia; this case report discusses how it was identified and managed, which matters for patients on the drug and clinicians...
Basal crypt dysplasia is easy to miss but linked to higher risk of advanced colorectal neoplasia in longstanding IBD. Improved recognition and use of p53 immunohistochemistry or complementary biomarkers could affect...
This preclinical study suggests a traditional medicinal plant extract may reduce inflammation and tissue damage in an experimental model of ulcerative colitis, which could guide future drug-discovery research relevant to...
TL1A-DR3 is implicated in both inflammation and fibrosis in IBD, so targeting it could address active disease and reduce fibrotic complications that lead to strictures. New TL1A-blocking antibodies are already in...
Based on the title and source metadata, this appears to be a case report related to Crohn's disease, Inflammatory bowel disease, and Fistula. The original article is from cureus.com.
Surveillance colonoscopies in IBD are meant to detect dysplasia or cancer; this report shows some solitary polyps may be benign retention polyps. Correct endoscopic removal and pathology spare patients from unnecessary...
Perianal fistulas are a serious, common complication of Crohn's disease that are often difficult to heal. This study tests a real-world combination of surgery plus an approved IL-23 inhibitor (mirikizumab) to see if...
The study links TXNIP/NLRP3 inflammatory signaling to disease features in an animal UC model and tests engeletin and rosuvastatin as interventions that lowered inflammatory markers—information relevant to researchers...
