Article Archive

Page 36 of 100 · 4779 patient-friendly summaries

Next-Generation Solid Dispersion of Andrographolide Attenuated Inflammation and Oxidative Stress in an Activated RAW264.7 Macrophage-Based In Vitro Model Relevant to Ulcerative Colitis
AAPS PharmSciTech

Next-Generation Solid Dispersion of Andrographolide Attenuated Inflammation and Oxidative Stress in an Activated RAW264.7 Macrophage-Based In Vitro Model Relevant to Ulcerative Colitis

The study reports anti-inflammatory and antioxidant effects of a new andrographolide formulation in a macrophage model relevant to ulcerative colitis, highlighting a potential early-stage therapeutic lead that may...

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Rapid growth of a giant inflammatory polyp mimicking rectal malignancy in well-controlled Crohn’s colitis: a diagnostic and therapeutic challenge
Baylor University Medical Center Proceedings

Rapid growth of a giant inflammatory polyp mimicking rectal malignancy in well-controlled Crohn’s colitis: a diagnostic and therapeutic challenge

Based on the title and source metadata, this appears to be a case report related to Crohn's disease, Inflammatory bowel disease, and Procedures and surgery. The original article is from Baylor University Medical Center...

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Macrophage pyroptosis in inflammatory bowel disease: mechanistic insights, pathological roles and treatment strategies
Frontiers in Immunology

Macrophage pyroptosis in inflammatory bowel disease: mechanistic insights, pathological roles and treatment strategies

Macrophage pyroptosis is increasingly implicated in driving intestinal inflammation and barrier damage in IBD, so understanding it could point to new treatment targets. Patients and clinicians may find this research...

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Clostridioides difficile in Paediatric Inflammatory Bowel Disease: A Retrospective Cross-Sectional Analysis of the East London Region.
Journal of paediatrics and child health

Clostridioides difficile in Paediatric Inflammatory Bowel Disease: A Retrospective Cross-Sectional Analysis of the East London Region.

C. difficile can cause or complicate diarrhoea in children with IBD, so understanding test positivity in this group helps clinicians interpret results and decide when to investigate or treat. The study suggests...

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Conserved Epithelial Remodeling Programs Underlie Pediatric Juvenile Colorectal Polyps Associated with Allergic Sensitization
International Journal of Molecular Sciences

Conserved Epithelial Remodeling Programs Underlie Pediatric Juvenile Colorectal Polyps Associated with Allergic Sensitization

Juvenile colorectal polyps in children show strong type 2 inflammatory and epithelial-remodeling programs that could explain links with allergic sensitization and suggest biomarkers and pathways relevant to mucosal...

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Nutritional Status and Linear Growth at Diagnosis and Their Association with Clinical Outcomes in Paediatric Inflammatory Bowel Disease: A Multicentre Cohort Study
Nutrients

Nutritional Status and Linear Growth at Diagnosis and Their Association with Clinical Outcomes in Paediatric Inflammatory Bowel Disease: A Multicentre Cohort Study

Malnutrition and growth failure at diagnosis are common in children with IBD—especially Crohn’s—and can indicate higher inflammatory burden. Monitoring and addressing nutrition and growth is important because most...

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Comparative Cost-Effectiveness of Advanced Treatment Sequences for Moderately to Severely Active Ulcerative Colitis in Japan
Advances in Therapy

Comparative Cost-Effectiveness of Advanced Treatment Sequences for Moderately to Severely Active Ulcerative Colitis in Japan

This study models comparative cost-effectiveness across many advanced therapy sequences for moderate–severe ulcerative colitis in Japan; its findings could influence how health systems and clinicians consider first- and...

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The role of nutritional risk in inflammatory bowel disease: a serial mediation model through fecal calprotectin and depression leading to impaired quality of life
Frontiers in Nutrition

The role of nutritional risk in inflammatory bowel disease: a serial mediation model through fecal calprotectin and depression leading to impaired quality of life

Nutritional risk, gut inflammation (measured by fecal calprotectin), and depression were linked to worse quality of life in people with IBD. Recognizing and addressing nutrition, inflammation, and mood together could...

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From Preclinical phase of Crohn’s disease to Post-operative Recurrence: Shared Mechanisms and Potential Interventions
PubMed Central

From Preclinical phase of Crohn’s disease to Post-operative Recurrence: Shared Mechanisms and Potential Interventions

This review highlights shared biomarkers and mechanisms between early Crohn's disease and post-operative recurrence, which could improve prediction and lead to preventive strategies for recurrence after surgery.

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A functional immune-based platform for donor-recipient matching in faecal microbiota transplantation for inflammatory bowel disease.
EBioMedicine

A functional immune-based platform for donor-recipient matching in faecal microbiota transplantation for inflammatory bowel disease.

The paper presents a proof-of-concept immune-based assay to match donors and recipients for FMT in IBD, which could help explain variable FMT outcomes and improve donor selection if validated.

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β-Glucan alleviates colitis by remodeling the colonic microenvironment and promoting interleukin-33-driven active eosinophil differentiation.
Molecular immunology

β-Glucan alleviates colitis by remodeling the colonic microenvironment and promoting interleukin-33-driven active eosinophil differentiation.

The study identifies a β-glucan → IL-33 → active eosinophil pathway that reduced colitis in a mouse model, suggesting a novel immunomodulatory mechanism that could inform future IBD research.

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Artificial intelligence for inflammatory bowel disease dysplasia detection: Current evidence and future directions
Artificial Intelligence in Gastrointestinal Endoscopy

Artificial intelligence for inflammatory bowel disease dysplasia detection: Current evidence and future directions

Dysplasia detection during colonoscopy is central to preventing colorectal cancer in people with IBD. AI tools could help, but current models often fail in inflamed or IBD-specific settings, so this review outlines...

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Intestinal Barrier Dysfunction in Ulcerative Colitis: Mechanisms and Therapeutic Perspectives
Medicine Insights

Intestinal Barrier Dysfunction in Ulcerative Colitis: Mechanisms and Therapeutic Perspectives

Intestinal barrier dysfunction is a likely driver of inflammation and flares in ulcerative colitis, so therapies that restore barrier integrity could help reduce disease activity and recurrence. This review highlights...

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MHC-Related Shared Genetic Susceptibility Between Ulcerative Colitis and Gastric Cancer in East Asians
Genes

MHC-Related Shared Genetic Susceptibility Between Ulcerative Colitis and Gastric Cancer in East Asians

The study suggests shared MHC/HLA genetic variants link ulcerative colitis and gastric cancer risk in East Asians, highlighting potential common immune-related susceptibility that could inform research on disease...

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Influence of Ageing on the Pharmacology, Efficacy and Safety of Oral Targeted Therapies for Inflammatory Bowel Disease: Focus on Janus Kinase (JAK) Inhibitors and Sphingosine-1-Phosphate (S1P) Receptor Modulators.
Drugs & aging

Influence of Ageing on the Pharmacology, Efficacy and Safety of Oral Targeted Therapies for Inflammatory Bowel Disease: Focus on Janus Kinase (JAK) Inhibitors and Sphingosine-1-Phosphate (S1P) Receptor Modulators.

Older adults with IBD are under-represented in trials, so age-specific benefits and harms of newer oral drugs (JAK inhibitors and S1P modulators) are uncertain. Clinicians and patients may need to weigh efficacy against...

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Pretreatment Histopathological Features are Associated with Ustekinumab Efficacy in Ulcerative Colitis: A Retrospective Pilot Study.
Digestive diseases (Basel, Switzerland)

Pretreatment Histopathological Features are Associated with Ustekinumab Efficacy in Ulcerative Colitis: A Retrospective Pilot Study.

If pre‑treatment biopsy features predict response to ustekinumab, clinicians might better select which UC patients are likely to benefit, potentially avoiding ineffective therapy for some and speeding effective treatment...

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An interpretable weighted graph convolutional network (W-GCN) framework for noninvasive assessment of ulcerative colitis severity
Biomedical Signal Processing and Control

An interpretable weighted graph convolutional network (W-GCN) framework for noninvasive assessment of ulcerative colitis severity

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Biomedical Signal...

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Evaluating embryo euploidy among patients diagnosed with inflammatory bowel disease undergoing in vitro fertilization.
Minerva obstetrics and gynecology

Evaluating embryo euploidy among patients diagnosed with inflammatory bowel disease undergoing in vitro fertilization.

People with IBD often worry whether their disease affects fertility or embryo health. This study directly looks at embryo chromosomal normality during IVF and found similar euploidy rates in patients with and without...

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Transition of children with chronic gastrointestinal and liver disease to adult care: A multicentre Asian survey of paediatric gastroenterologists
Journal of Pediatric Gastroenterology and Nutrition

Transition of children with chronic gastrointestinal and liver disease to adult care: A multicentre Asian survey of paediatric gastroenterologists

Coordinated transition to adult gastroenterology affects continuity of care for children with chronic GI conditions such as IBD; improvements could reduce gaps in treatment and support during young adulthood.

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Best practices for prior authorization in pediatric inflammatory bowel disease: A practical multidisciplinary roadmap
Journal of Pediatric Gastroenterology and Nutrition

Best practices for prior authorization in pediatric inflammatory bowel disease: A practical multidisciplinary roadmap

Based on the title and source metadata, this appears to be a patient education related to Inflammatory bowel disease and Pediatrics and family. The original article is from Journal of Pediatric Gastroenterology and...

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Engineering IL-10-Overexpressing MSCs via a Non-Viral PEG-PEI Nanoplatform for Potent Therapy of Inflammatory Bowel Disease.
ACS applied bio materials

Engineering IL-10-Overexpressing MSCs via a Non-Viral PEG-PEI Nanoplatform for Potent Therapy of Inflammatory Bowel Disease.

Researchers are exploring ways to improve cell therapies for IBD by making therapeutic cells produce anti-inflammatory molecules like IL-10. If scalable and safe, non-viral engineering of MSCs could lead to...

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Development and Evaluation of Carvacrol-Pectin/Chitosan Complex for Colon Targeted Drug Delivery in Ulcerative Colitis
Journal of Pharmaceutical Innovation

Development and Evaluation of Carvacrol-Pectin/Chitosan Complex for Colon Targeted Drug Delivery in Ulcerative Colitis

New colon-targeted formulations aim to concentrate treatment where inflammation is in ulcerative colitis, which could increase benefit and reduce systemic side effects. Formulation research like this is an early step...

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Climate classification, sociodemographic development, and the burden of inflammatory bowel disease in tropical countries
Tropical Medicine and Health

Climate classification, sociodemographic development, and the burden of inflammatory bowel disease in tropical countries

The work links climate and sociodemographic context to IBD burden in tropical regions, which can influence diagnostic recognition, resource needs, and research priorities for communities where IBD is rising.

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Quantitative image feature integrated digital pathology model based on deep learning and machine learning for binary histological severity stratification of ulcerative colitis
BMC Gastroenterology

Quantitative image feature integrated digital pathology model based on deep learning and machine learning for binary histological severity stratification of ulcerative colitis

Automated, quantitative analysis of pathology slides could reduce variability in histological scoring and help track histological healing — a growing therapeutic target in ulcerative colitis.

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Piezo mechanosensitive channels: A biological hub for intestinal barrier homeostasis and an emerging target for disease intervention
World Journal of Gastroenterology

Piezo mechanosensitive channels: A biological hub for intestinal barrier homeostasis and an emerging target for disease intervention

Piezo channels appear central to how mechanical signals influence the gut barrier, immunity, and secretion — processes that can affect inflammation and symptoms in IBD, IBS, and colon cancer. Understanding them could...

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From polymorphism to phenotype: FADS2 rs174538, fatty acid signatures and disease activity in Japanese Crohn’s disease
World Journal of Gastroenterology

From polymorphism to phenotype: FADS2 rs174538, fatty acid signatures and disease activity in Japanese Crohn’s disease

This study links genetic variation in fatty-acid–desaturase genes with membrane PUFA profiles and inflammatory markers in Crohn’s disease. If replicated, erythrocyte desaturase indices could become integrative biomarkers...

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Letter to the Editor: From antibiotic exposure to antibiotic intensity: Rethinking inpatient stewardship in inflammatory bowel disease
World Journal of Gastroenterology

Letter to the Editor: From antibiotic exposure to antibiotic intensity: Rethinking inpatient stewardship in inflammatory bowel disease

Antibiotic use patterns in hospitalized IBD patients affect infection risks, microbiome impact, resistance pressure, length of stay, and costs. Shifting focus from simple exposure counts to intensity and escalation can...

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Low-Dose Naltrexone in Crohn's Disease: A Prematurely Terminated Randomized Trial Showing Reduced Fatigue Without Clinical or Endoscopic Benefit.
Digestive diseases and sciences

Low-Dose Naltrexone in Crohn's Disease: A Prematurely Terminated Randomized Trial Showing Reduced Fatigue Without Clinical or Endoscopic Benefit.

A controlled trial found low-dose naltrexone did not induce endoscopic or clinical remission in Crohn's disease, but it showed a possible benefit for reducing fatigue. Patients seeking symptom relief without...

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Elucidating Fh15-Mediated Modulation of TLR4/NF-kB in Neutrophils to SuppressInflammation in Sepsis and Ulcerative colitis
NIH RePORTER

Elucidating Fh15-Mediated Modulation of TLR4/NF-kB in Neutrophils to SuppressInflammation in Sepsis and Ulcerative colitis

Researchers are studying a parasite-derived protein (Fh15) that may reduce neutrophil-driven inflammation in sepsis and ulcerative colitis models; this could point toward new anti-inflammatory drug approaches in the...

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