Article Archive

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Sanggenol L Regulates Nrf2/HO-1/p65 Signalling Pathways via Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice
Bratislava Medical Journal

Sanggenol L Regulates Nrf2/HO-1/p65 Signalling Pathways via Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice

Researchers exploring new anti-inflammatory or antioxidant compounds for ulcerative colitis may find sanggenol L’s effects on Nrf2/HO-1 and TLR4/p65 signalling of interest. Patients should note this is early-stage,...

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Fecal microbiota transplantation in ulcerative colitis: mucosal immune mechanisms and precision microbiota therapy
Frontiers in Immunology

Fecal microbiota transplantation in ulcerative colitis: mucosal immune mechanisms and precision microbiota therapy

FMT and precision microbiota therapies target the gut ecosystem, a modifiable factor in UC. For people with UC, this review explains potential mechanisms, where FMT has shown benefit in trials, and why it is still...

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Association of serological markers with endoscopic mucosal healing and disease activity in patients with inflammatory bowel disease: a retrospective study
Frontiers in Immunology

Association of serological markers with endoscopic mucosal healing and disease activity in patients with inflammatory bowel disease: a retrospective study

Blood markers that correlate with endoscopic healing could help track inflammation noninvasively and may reduce the frequency of endoscopy if validated. For people with IBD, better blood-based tools could make monitoring...

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A Novel Human Intestinal Organoid Platform with Peristaltic Function for Drug Discovery and Pre-Clinical Testing in GI Motility Disorders
NIH RePORTER

A Novel Human Intestinal Organoid Platform with Peristaltic Function for Drug Discovery and Pre-Clinical Testing in GI Motility Disorders

A validated human peristaltic intestinal organoid model could make preclinical testing more predictive for drugs affecting gut motility and reduce reliance on animal models.

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Ulcerative colitis with a mutation in the HMBS gene associated with acute intermittent porphyria
Experimental and Clinical Gastroenterology

Ulcerative colitis with a mutation in the HMBS gene associated with acute intermittent porphyria

Finding a pathogenic HMBS variant in a child with extensive ulcerative colitis suggests rare genetic conditions (like acute intermittent porphyria) can appear alongside or mimic IBD and might affect symptoms or...

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Features of the course and therapeutic strategy of ulcerative colitis in liver transplant recipients
Experimental and Clinical Gastroenterology

Features of the course and therapeutic strategy of ulcerative colitis in liver transplant recipients

People with IBD who undergo liver transplantation — especially those with PSC — can have different UC course and treatment needs because transplant immunosuppression and the liver disease itself affect the bowel.

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Systematic Review: Evaluating the Prognostic Value of Granulomas in Crohn’s Disease
Digestive Diseases and Sciences

Systematic Review: Evaluating the Prognostic Value of Granulomas in Crohn’s Disease

Granulomas are a classic histologic feature of Crohn’s disease, so patients and clinicians may wonder whether their presence predicts worse disease or different treatment needs. This review shows existing studies are...

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Current and emerging therapeutic strategies targeting adherent-invasive Escherichia coli in Crohn’s disease: a review
Gut Pathogens

Current and emerging therapeutic strategies targeting adherent-invasive Escherichia coli in Crohn’s disease: a review

Adherent-invasive E. coli (AIEC) is implicated in Crohn’s disease inflammation in some patients. This review maps possible ways to target AIEC specifically, which could lead to therapies that reduce infection-driven...

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Lactobacillus johnsonii mediates the protective effects of pristimerin against ulcerative colitis and concomitant liver injury through remodeling hepatic lipid metabolism via LXRα-SCD1 axis.
Gut microbes

Lactobacillus johnsonii mediates the protective effects of pristimerin against ulcerative colitis and concomitant liver injury through remodeling hepatic lipid metabolism via LXRα-SCD1 axis.

The study identifies a gut bacteria–liver signaling axis (Lactobacillus johnsonii → hepatic LXRα–SCD1) that may explain how altered hepatic lipids contribute to UC and related liver injury, and shows pristimerin can...

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Extraintestinal manifestations have a negative impact on Quality of Life of patients with Inflammatory Bowel Disease
Digestion

Extraintestinal manifestations have a negative impact on Quality of Life of patients with Inflammatory Bowel Disease

Extraintestinal manifestations are common in IBD and — according to this study — linked to significantly worse quality of life across social, systemic, intestinal, and emotional domains. Recognizing and treating EIMs may...

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Editorial on ‘Lowering the C‐Reactive Protein ( CRP ) Threshold Improves Risk Stratification in Acute Ulcerative Colitis: A Propensity‐Matched Analysis’
Alimentary Pharmacology & Therapeutics

Editorial on ‘Lowering the C‐Reactive Protein ( CRP ) Threshold Improves Risk Stratification in Acute Ulcerative Colitis: A Propensity‐Matched Analysis’

Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and CRP. The original article is from Alimentary Pharmacology & Therapeutics.

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Management of endoscopic rectal activity in ulcerative colitis: real-world adherence to guidelines and clinical outcomes.
European journal of gastroenterology & hepatology

Management of endoscopic rectal activity in ulcerative colitis: real-world adherence to guidelines and clinical outcomes.

The study examines whether recommended management for rectal inflammation in UC is followed in routine care and whether following guidelines affects 12-month remission — important for patients and clinicians aiming for...

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Factors associated with preference for in-person versus remote consultations in inflammatory bowel disease in the United Kingdom: secondary analysis of an online survey.
European journal of gastroenterology & hepatology

Factors associated with preference for in-person versus remote consultations in inflammatory bowel disease in the United Kingdom: secondary analysis of an online survey.

Patients and clinics are still deciding how much care can be done remotely. Knowing who prefers in-person versus remote visits helps tailor care so patients receive the visit type they need and want, and supports...

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Further considerations on long-term outcomes following ileal pouch-anal anastomosis for ulcerative colitis.
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

Further considerations on long-term outcomes following ileal pouch-anal anastomosis for ulcerative colitis.

Based on the title and source metadata, this appears to be an opinion or commentary related to Ulcerative colitis and Procedures and surgery. The original article is from Colorectal disease : the official journal of the...

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Standard malnutrition screening tools inadequately capture comprehensive nutritional needs in outpatients with inflammatory bowel disease.
Crohn's & colitis 360

Standard malnutrition screening tools inadequately capture comprehensive nutritional needs in outpatients with inflammatory bowel disease.

Standard measures like BMI and routine labs can miss muscle and fat depletion in IBD patients. Better screening plus access to dietitian assessment could find treatable malnutrition that affects recovery and quality of...

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Magnoflorine, a dietary alkaloid from Alpinia oxyphylla fruit, ameliorates colitis by restoring intestinal barrier and dual modulation of JAK/STAT3 pathway.
Food chemistry

Magnoflorine, a dietary alkaloid from Alpinia oxyphylla fruit, ameliorates colitis by restoring intestinal barrier and dual modulation of JAK/STAT3 pathway.

The study identifies a food-derived compound that improved colitis in lab models and acted on JAK/STAT3 signaling and intestinal barrier proteins—pathways relevant to IBD inflammation and mucosal healing.

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Immunomodulatory biomaterials as a novel therapeutic platform for inflammatory bowel disease.
Therapeutic advances in gastroenterology

Immunomodulatory biomaterials as a novel therapeutic platform for inflammatory bowel disease.

Biomaterials that directly modify immune responses could offer new localized, targeted ways to treat gut inflammation, potentially reducing reliance on systemic immunosuppressive drugs. This review summarizes preclinical...

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Hierarchical correlates of sexual dysfunction in inflammatory bowel disease: Psychological burden outweighs disease activity and sarcopenia.
Journal of psychosomatic research

Hierarchical correlates of sexual dysfunction in inflammatory bowel disease: Psychological burden outweighs disease activity and sarcopenia.

Sexual dysfunction is common in IBD and—according to this study—appears more strongly linked to psychological and demographic factors than to disease activity or muscle loss. Recognizing and treating mental-health issues...

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Feasibility, Acceptability, and Preliminary Effects of a Nurse-Delivered Self-Management Program for Individuals with Inflammatory Bowel Disease: A Pilot Randomized Controlled Trial
Digestive Diseases and Sciences

Feasibility, Acceptability, and Preliminary Effects of a Nurse-Delivered Self-Management Program for Individuals with Inflammatory Bowel Disease: A Pilot Randomized Controlled Trial

Self‑management programs delivered by nurses may help people with IBD improve daily functioning, confidence in managing their condition, and quality of life even when inflammation markers don’t change. That matters...

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Lowering the C-Reactive Protein (CRP) Threshold Improves Risk Stratification in Acute Ulcerative Colitis: A Propensity-Matched Analysis.
Alimentary pharmacology & therapeutics

Lowering the C-Reactive Protein (CRP) Threshold Improves Risk Stratification in Acute Ulcerative Colitis: A Propensity-Matched Analysis.

People hospitalized with ulcerative colitis who don’t meet classic severe-disease criteria can still face meaningful colectomy risk. Using a lower CRP cutoff might help clinicians identify more high-risk patients...

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Lowering the C‐Reactive Protein ( CRP ) Threshold Improves Risk Stratification in Acute Ulcerative Colitis: A Propensity‐Matched Analysis
Alimentary Pharmacology & Therapeutics

Lowering the C‐Reactive Protein ( CRP ) Threshold Improves Risk Stratification in Acute Ulcerative Colitis: A Propensity‐Matched Analysis

Lowering the CRP cutoff could help hospitals identify hospitalized UC patients at higher risk of needing surgery who are currently classified as less severe. That may affect monitoring and treatment decisions during...

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A microbiome meta-transcriptomics pipeline identifies a neutrophil elastase inhibitor that protects the colonic epithelial barrier
Signal Transduction and Targeted Therapy

A microbiome meta-transcriptomics pipeline identifies a neutrophil elastase inhibitor that protects the colonic epithelial barrier

Identifies a microbiome-derived protein that inhibits a protease linked to epithelial damage in IBD and shows protective effects in lab and mouse models, pointing to a new therapeutic strategy focused on barrier...

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Immune Repertoire Profiling Reveals Distinct Adaptive Immune Signatures of Dampness ZHENG Across Psoriasis, Rheumatoid Arthritis and Ulcerative Colitis
Cell Proliferation

Immune Repertoire Profiling Reveals Distinct Adaptive Immune Signatures of Dampness ZHENG Across Psoriasis, Rheumatoid Arthritis and Ulcerative Colitis

This study suggests that subgrouping autoimmune diseases by a Traditional Chinese Medicine phenotype (Dampness ZHENG) corresponds to distinct T‑ and B‑cell receptor patterns.

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Co‐Occurring Autoimmune Disease in Crohn's Disease Versus Ulcerative Colitis: Complementary Data From a Diverse Urban Cohort
Journal of Gastroenterology and Hepatology

Co‐Occurring Autoimmune Disease in Crohn's Disease Versus Ulcerative Colitis: Complementary Data From a Diverse Urban Cohort

Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease, Ulcerative colitis, and Inflammatory bowel disease. The original article is from Journal of Gastroenterology and...

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M2 macrophage-based biohybrid system regulates intestinal microbiota homeostasis and immunity for the treatment of inflammatory bowel disease.
Acta biomaterialia

M2 macrophage-based biohybrid system regulates intestinal microbiota homeostasis and immunity for the treatment of inflammatory bowel disease.

The study tests a multi-targeted biohybrid that could—if translated—help address inflammation, oxidative stress, and dysbiosis together, a combination that current single-target IBD treatments often do not address.

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The dual role of RIPK family in IBD: from cell death to therapeutic targeting.
Molecular medicine (Cambridge, Mass.)

The dual role of RIPK family in IBD: from cell death to therapeutic targeting.

RIPK proteins are central to cell-death and inflammatory pathways that can damage the intestinal lining in IBD. Understanding them could point to new treatments that more precisely block harmful inflammation while...

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Circulating multi-omic signature of disease severity and cholangiocarcinoma in primary sclerosing cholangitis.
Hepatology communications

Circulating multi-omic signature of disease severity and cholangiocarcinoma in primary sclerosing cholangitis.

PSC can progress to cirrhosis and cholangiocarcinoma; circulating multi-omic signatures that track severity and cancer-associated changes could help explain disease biology and lead to biomarkers for risk stratification...

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