Ulcerative colitis

The trial tests two low-cost adjuncts — a Lactobacillus probiotic and a multi–trace-element supplement — added to biologic-based standard care to see if they help maintain remission in ulcerative colitis. If effective,...

Faecal calprotectin appears to be the best non‑invasive test among those studied for distinguishing UC from Crohn’s disease and for reflecting mucosal inflammation. Simpler blood‑based scores may help gauge systemic...

If you or a loved one follow emerging IBD treatments, this update signals a new PALI-2108 program moving into Phase 2 for ulcerative colitis and planned Phase 2 testing in Crohn’s disease, plus a company focus on...

Nanotechnology approaches aim to improve how cytokine-targeting therapies are delivered in IBD, which could reduce systemic exposure and immunogenicity and increase local effectiveness.

Cure8 found this source from Intestinal research, but the page could not be read reliably yet. It is tagged for Ulcerative colitis, Inflammatory bowel disease, and Risankizumab. Open the original article for the full...

The study suggests most adults with chronic diarrhea in this tertiary setting had organic/inflammatory disease and identifies accessible clinical and lab predictors that could help prioritize endoscopic evaluation.

This filing reports that PALI‑2108, an investigational oral PDE4 prodrug for IBD, showed encouraging Phase 1 signals and is moving into Phase 2 trials — a step toward more definitive efficacy data. The company also...

This trial tested a dietary supplement (nicotinamide riboside) as an add-on for pediatric ulcerative colitis with the goal of improving cellular metabolism in the gut lining. Patients and families may be interested...

Faecal microbiota transfer is being tested in a large Phase 3 trial as a possible new treatment approach for active ulcerative colitis, and this study also looks at safety and how the therapy changes the gut microbiome...

This trial tests a new oral drug, AC-101, for moderate-to-severe ulcerative colitis and may expand future treatment options if it proves effective and safe. The study targets patients who have failed or could not...

A reproducible large-animal colitis model could improve preclinical testing by better mimicking human gut anatomy and immune responses than rodent models. That may help translational research and therapy evaluation for...

A rare venous occlusive disease (IMHMV) can closely mimic steroid-refractory ulcerative colitis and may require surgery for diagnosis, so clinicians and patients should consider vascular causes when colitis is atypical...

This review pools available human and animal studies on sodium butyrate for ulcerative colitis and highlights promising signals—especially for oral microencapsulated formulations—while noting that clinical evidence is...

Researchers are exploring antioxidant strategies for colitis because oxidative stress contributes to mucosal damage; preclinical positive signals could eventually lead to new adjunctive therapies for ulcerative colitis...

People with UC often seek dietary strategies to help manage inflammation; this study uses AI and docking to prioritize polyphenols and foods for future testing, which could guide research and eventually inform dietary...

People with Crohn's disease or ulcerative colitis might see more AI-based prognostic tools in the literature, but this review shows most models are not yet proven ready for clinical use because they lack key validation...

Patients with ulcerative colitis who cannot tolerate 5-ASA need alternative maintenance options. This study suggests azathioprine showed comparable continuation, safety, and endoscopic outcomes whether or not patients...

If true, the study suggests that long-term air pollution exposure may raise the risk of developing IBD and that greater adherence to a plant-based diet could be linked with a lower pollution-related risk. That may be...

Extraintestinal manifestations are common in IBD and can affect quality of life and clinical outcomes. A national consensus helps standardize recognition and multidisciplinary care, which may improve management for...

For people with UC and CMV colitis, whether to keep or stop immunosuppressive drugs during antiviral treatment may affect how quickly CMV clears from colon tissue and short-term adverse events.

People with UC may be interested because the study identifies a traditional herbal formulation that reduced disease markers in a mouse model and changed gut microbiota and inflammatory pathways (IL‑17), suggesting...

Keeping IBD well controlled before and during pregnancy lowers the risk of adverse outcomes for both parent and baby; understanding which medications are safe and which should be stopped is crucial for family planning.

Researchers are exploring a way to deliver biologic drugs directly in the gut using engineered B cells that become long-lived plasma cells. If successful, this could allow sustained, localized anti-inflammatory protein...

Researchers are studying whether everyday microplastic exposure could worsen gut barrier injury in IBD and contribute to inflammatory or mental-health effects linked by the gut–brain axis.

Bronchiectasis can be an overlooked extraintestinal manifestation in people with IBD and may cause respiratory symptoms long after IBD diagnosis. Recognizing this link could speed diagnosis and lead to different...

RDW is a cheap, routinely measured blood parameter; if it reliably reflects IBD presence or activity, it could be an easy additional tool to help detect flares or support assessment without extra testing.

Dysplasia is the key premalignant change that raises colorectal cancer risk in people with colonic IBD. Better detection and clearer management pathways can reduce cancer risk and help patients avoid unnecessary surgery.

ILD is a potentially serious extraintestinal complication that appears more often with ulcerative colitis than with Crohn’s disease in this cohort study. Patients with both IBD and ILD had higher healthcare use and...

People with IBD can sometimes have rare extraintestinal manifestations or overlapping autoimmune conditions; this report highlights an uncommon combination (relapsing polychondritis and Sweet syndrome) occurring with...

This preclinical study links cod skin–derived collagen peptides to reduced colitis severity in mice through changes in the gut microbiota and suppression of the NLRP3 inflammasome — pathways that could be relevant to...

This study explores a multi-component traditional medicine that the authors report can reduce experimental colitis and modulate inflammatory signaling and the gut microbiome — findings that could guide future preclinical...

Imaging can reveal characteristic bowel and vascular patterns that help distinguish Crohn's, UC, celiac disease, and systemic autoimmune or vasculitic causes of GI symptoms, which may speed diagnosis and detect dangerous...

This study examines whether patterns of body size from birth through adulthood add information about IBD risk beyond adult BMI and genetic susceptibility. Results suggest life-course size trajectories may be more related...

This study suggests people with IBD have lower morning cortisol and a blunted cortisol awakening response, patterns that may be linked to systemic inflammation.

People with IBD face higher rates of anxiety, depression and other psychiatric disorders that often begin years before diagnosis and can persist long term. Recognizing and treating mental-health issues early can improve...

The study describes a new oral delivery system designed to improve colon targeting and anti-inflammatory activity of celastrol, which could eventually lead to better drug options for ulcerative colitis if advanced to...

Anti‑TNF drugs are a mainstay of IBD treatment. Understanding that they act through several immune mechanisms (not only neutralizing soluble TNF‑α) helps explain differences in effectiveness and informs conversations...

Virtual care reduced long-distance travel for IBD patients in remote Ontario, which both improves access to specialty care and appears to meaningfully lower travel-related CO2 emissions. Patients and clinics interested...

Patients and clinicians may care because the study suggests contrast-enhanced CT can reliably detect and localize IBD, including transmural and small-bowel disease that biopsies miss, which could affect diagnostic...

The study presents a new edible nanoparticle that delivers resveratrol to the colon and improved disease markers in a mouse model of ulcerative colitis, which could inform future delivery strategies for plant-derived...

Handheld IUS could make noninvasive bowel assessment faster and more accessible for people with IBD, helping with triage and short-term monitoring without immediately resorting to endoscopy or advanced imaging.

If validated, metabolite patterns could help predict which children will reach remission on vedolizumab, potentially guiding treatment choices and avoiding ineffective therapy.

A blood antibody (anti-integrin αvβ6) was associated with relapse risk in UC and may help predict who stays in long-term remission, which could affect monitoring and treatment planning.

People with IBD face higher osteoporosis risk; this study looked for a genetic variant (LCT-13910C>T) that might affect bone density but found no clear link in this cohort, so it does not change current bone-health...

The review links specific therapies and surgical options to outcomes that matter to people with IBD — mucosal healing, lower hospitalizations, and reduced need for surgery — and highlights that combining medical and...

People with an ileal pouch (J‑pouch) may experience pouch inflammation (pouchitis). This report suggests starting GLP‑1 receptor agonists might be followed by pouchitis in some cases, which could affect medication...

The paper identifies a new mechanism (VDAC1-driven mtDNA release activating cGAS–STING) that may drive inflammation in ulcerative colitis and a candidate compound (senkyunolide I) that blocks this pathway in preclinical...

The paper describes a new immunometabolic mechanism that strengthened intestinal barrier function and reduced colitis in mice, suggesting a potential pathway to develop therapies that boost ILC3-driven IL-22 production...