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Ulcerative colitis news across medications, symptoms, monitoring, procedures, research, access, and daily life.
Page 26 of 41 · 1922 articles
People with UC in remission who still have gut–brain interaction symptoms often look for safe ways to improve symptoms or gut microbiota balance.
This trial is testing whether continued mirikizumab treatment helps children and teens with ulcerative colitis or Crohn’s disease achieve and maintain remission over the long term. Results could expand pediatric...
Real-world PSP registries can show how long people stay on vedolizumab and how it’s used alongside or compared with other advanced therapies like tofacitinib. That information can help patients and clinicians understand...
People with IBD who have no or few symptoms but still have moderate–severe inflammation on endoscopy face uncertainty about whether to switch therapies to aim for endoscopic remission.
Dietary strategies like the Mediterranean diet and time-restricted feeding could be low-risk ways to influence gut microbiota, short-chain fatty acids, and inflammation in people with ulcerative colitis; this trial will...
The study suggests a Moringa-derived polysaccharide may reduce inflammation in a mouse model of ulcerative colitis by altering gut microbiota, metabolites, and inflammatory/antioxidant signaling — a potential preclinical...
Preneoplastic (adenomatous and serrated) polyps can be precursors to colorectal cancer, so knowing how common they are and what raises risk may affect surveillance planning for people with ulcerative colitis.
Respiratory viral infections can be more serious in immunosuppressed patients. This study suggests systemic steroids (prednisolone) — but not biologics or immunomodulators in this dataset — were linked to higher...
Crohn's-like disease of the pouch is a meaningful complication after IPAA that can impair quality of life and risk pouch failure; knowing which drug classes show promise for specific pouch phenotypes can guide...
Based on the title and source metadata, this appears to be a clinical study related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of...
If you have PSC-IBD or care for someone who does, this study suggests the gut microbiota and its ability to make secondary bile acids may help drive inflammation and colorectal dysplasia risk.
Researchers are exploring natural compounds that may modulate gut microbes, barrier function, and immune signaling relevant to ulcerative colitis.
For people with ulcerative colitis who have already tried and failed one or more advanced therapies, this study suggests upadacitinib may lead to higher rates of steroid-free clinical remission and endoscopic healing...
Psychiatric disorders (especially depression, anxiety, and substance misuse) are more common in people with IBD starting a few years before diagnosis and remaining higher for years after. Recognizing this link can help...
The study presents preclinical data that an orally delivered biotherapeutic (EPICERTIN) promotes epithelial repair and reduces inflammation in a UC-relevant mouse model — a potential step toward therapies that directly...
If validated, a simple ultrasound-based score could reduce the need for invasive endoscopy to monitor disease activity in children with ulcerative colitis. Noninvasive monitoring is especially valuable in pediatrics.
This study addresses whether removing the appendix changes long-term UC outcomes. People with UC or their clinicians might expect surgery to alter disease course; these real-world data suggest it generally does not for...
Most people with IBD can have children safely with modern treatments and planning; uncontrolled disease poses greater risks to pregnancy than continuing most IBD medications. Planning and specialist input before...
Biologic therapy and steroid withdrawal were temporally associated with severe eosinophilic myocarditis in a patient with ulcerative colitis — a life-threatening but potentially treatable complication. Early recognition...
Researchers and clinicians looking for blood- or tissue-based molecular tests for IBD may find these integrated transcriptomic analyses useful because they identify candidate diagnostic biomarkers and highlight shared...
TL1A-blocking antibodies have shown promising response rates in early trials for both Crohn's disease and ulcerative colitis. Understanding TL1A biology could help match new therapies to the patients most likely to...
This paper highlights the emotional and social aftermath of colectomy and J‑pouch surgery for people with ulcerative colitis, a topic that directly affects patients facing or living with these procedures.
The analysis suggests that placebo arms in Phase 3 IBD trials are associated with higher rates of serious events, mainly disease exacerbations; this matters because it raises ethical and safety concerns for people with...
If validated in clinical studies, extending the interval between subcutaneous vedolizumab doses could reduce injection frequency, costs, and treatment burden for some patients on maintenance therapy.
Early, noninvasive biomarkers could help detect ulcerative colitis and related colorectal cancer risk sooner. This study identifies four serum-accessible proteins with promising diagnostic accuracy in the reported...
This trial directly informs a common clinical question: whether patients in deep remission can safely stop anti‑TNF therapy. Results show higher relapse risk after withdrawal, but many patients can be successfully...
This study describes a new plant-derived nanoparticle (EBDEVs) that reduced inflammation and improved colon health in a mouse model of ulcerative colitis and altered the gut microbiota — early evidence that may guide...
The study proposes a targeted oral delivery method that could help concentrate anti-inflammatory natural compounds at inflamed colon sites, potentially improving treatment effectiveness for ulcerative colitis while...
CVID can cause GI problems that closely mimic Crohn’s disease, ulcerative colitis, or celiac disease and may change diagnostic and treatment choices. Gastroenterologists need to consider CVID when IBD presentations are...
Weight loss before or around colectomy/IPAA could affect surgical risk and recovery; this study tests an endoscopic, non‑surgical weight‑loss procedure specifically in people with ulcerative colitis who are planning...
A new investigational drug (BI 3032950) is being tested specifically for people with ulcerative colitis who did not do well on prior biologic or targeted treatments. If effective and safe, it could become another option...
This trial tested a rectal hydrocortisone formulation specifically for ulcerative proctitis, a form of ulcerative colitis limited to the rectum. If effective and safe, a local steroid suppository could offer targeted...
Patients on anti-TNF biologics often seek safe ways to support gut microbial health. This trial tests a prebiotic supplement (2'-FL) for safety and whether it increases beneficial bacteria and butyrate in young people...
Bowel urgency is a common, distressing symptom in ulcerative colitis; a minimally invasive implant that reduces urgency could improve daily functioning and quality of life if proven effective and safe.
Mental health problems often begin before IBD is diagnosed and stay higher for years after; addressing psychiatric symptoms early could improve overall disease management and quality of life for people with Crohn’s...
A genetic marker (HLA-DRB1*01:03) was linked to more severe IBD outcomes—higher rates of colectomy/colonic surgery, more perianal disease, earlier use and higher failure of advanced therapies—which could help explain...
People with Crohn’s disease on ustekinumab may be more likely to need intensified dosing if they previously tried biologics or immunomodulators or have had disease longer; this could affect monitoring and planning. For...
Surgical choices for ulcerative colitis—permanent ileostomy versus ileal pouch (IPAA)—lead to very different daily-life outcomes. Understanding risks and lifestyle tradeoffs and using shared decision-making helps...
Depression and suicide are important concerns for people with IBD. This study shows higher hospitalization risk for depression in IBD but a decline in those hospitalizations over time, which may reflect changing care...
The study suggests people with Crohn's disease or ulcerative colitis have higher lipoprotein(a) levels than healthy controls, which could be relevant because Lp(a) is a cardiovascular-risk biomarker and cardiovascular...
Based on the title and source metadata, this appears to be a case report related to Ulcerative colitis, Inflammatory bowel disease, and Genetics and genomics. The original article is from Cureus.
A probe that images superoxide in inflamed colons could help researchers study oxidative stress in ulcerative colitis and potentially guide development of new biomarkers or imaging approaches.
This study highlights that people who go on to develop myasthenia gravis had higher rates of other autoimmune diagnoses in the years beforehand, which may be relevant for clinicians tracking autoimmune comorbidity...
If approved, a vedolizumab biosimilar could increase treatment options and competitive pricing for adults with moderate-to-severe ulcerative colitis or Crohn's disease. The company already markets a natalizumab...
Researchers tested a ginger-derived glucan that reduced inflammation and reshaped the gut microbiota in a mouse colitis model — a potential prebiotic approach that could inform future IBD therapies or dietary strategies.
PSC occurring with IBD changes cancer risk and surveillance needs: patients can have extensive but asymptomatic colitis and a higher colorectal and biliary cancer risk. The review outlines gaps in diagnosis, monitoring,...
This study reports a new colon-targeted delivery system for unconjugated bilirubin that reduced inflammation and improved mucosal healing in a mouse model of ulcerative colitis; it could inform future drug-development...
This study expands knowledge of UC genetics in an understudied Indian population and points to genes and pathways that could help explain disease mechanisms different from those identified in Western cohorts. That could...
