All topics

Symptoms and flares

Diarrhea, abdominal pain, fatigue, bleeding, urgency, flares, remission, and symptom management news.

Page 2 of 5 · 217 articles

Idiopathic myointimal hyperplasia of mesenteric veins mimicking steroid-refractory ulcerative colitis
World Journal of Gastroenterology

Idiopathic myointimal hyperplasia of mesenteric veins mimicking steroid-refractory ulcerative colitis

A rare venous occlusive disease (IMHMV) can closely mimic steroid-refractory ulcerative colitis and may require surgery for diagnosis, so clinicians and patients should consider vascular causes when colitis is atypical...

Read Summary
A Case Study of PSTPIP1-Associated Myeloid-Related Proteinemia Inflammatory Syndrome Masquerading as Inflammatory Bowel Disease.
Inflammatory intestinal diseases

A Case Study of PSTPIP1-Associated Myeloid-Related Proteinemia Inflammatory Syndrome Masquerading as Inflammatory Bowel Disease.

Some rare autoinflammatory disorders can look like IBD but need different diagnostic thinking. Recognizing systemic signs and checking serum zinc may lead to a correct diagnosis and targeted care.

Read Summary
Optimism and mindfulness are associated with decreased abdominal pain among adolescents with inflammatory bowel disease.
Journal of the Canadian Association of Gastroenterology

Optimism and mindfulness are associated with decreased abdominal pain among adolescents with inflammatory bowel disease.

Adolescents with IBD often experience abdominal pain that affects daily life. This study suggests psychological resilience — especially optimism and mindfulness — is linked with less pain, pointing to nonpharmacologic...

Read Summary
Combined Enterococcus faecium SF68®–Butyrate–Folate Supplementation Restores Intestinal Barrier Integrity and Epithelial Metabolic Function in Experimental DSS-Induced Colitis
Springer Science and Business Media LLC

Combined Enterococcus faecium SF68®–Butyrate–Folate Supplementation Restores Intestinal Barrier Integrity and Epithelial Metabolic Function in Experimental DSS-Induced Colitis

The study suggests a combined probiotic-plus-nutrient approach may improve intestinal barrier integrity, reduce inflammation, and restore epithelial metabolism in an IBD model—areas not fully addressed by current...

Read Summary
Innate immune recognition of Debaryomyces hansenii requires Dectin-1-Card9 signaling.
Infection and immunity

Innate immune recognition of Debaryomyces hansenii requires Dectin-1-Card9 signaling.

Researchers found that immune cells detect the gut-associated yeast Debaryomyces hansenii via Dectin-1 and Card9, and the yeast was enriched in Crohn’s disease ulcers. That suggests a possible microbial–immune link...

Read Summary
Molecular mechanisms of allergic type 2 immunity in the pathogenesis of Crohn's disease: From epithelial alarmins to IgE signaling.
Cellular and molecular biology (Noisy-le-Grand, France)

Molecular mechanisms of allergic type 2 immunity in the pathogenesis of Crohn's disease: From epithelial alarmins to IgE signaling.

The review suggests that allergic-type (type 2) immune pathways may play a meaningful role in some people with Crohn's disease, which could point to new treatment options that target IgE, Th2 cytokines, epithelial...

Read Summary
Erythritol Exacerbates DSS-Induced Colitis and Influences Behavioral Responses in Mice Through Gut Microbiota and Metabolic Alterations
Microorganisms

Erythritol Exacerbates DSS-Induced Colitis and Influences Behavioral Responses in Mice Through Gut Microbiota and Metabolic Alterations

This study suggests erythritol — a common non-nutritive sweetener — may worsen experimental colitis and depression-like behavior in mice via microbiome and metabolic changes, raising questions about how ultra-processed...

Read Summary
Features and Outcomes of Inflammatory Bowel Disease among Filipino Children in a Tertiary Hospital: An Eleven-year Review.
Acta medica Philippina

Features and Outcomes of Inflammatory Bowel Disease among Filipino Children in a Tertiary Hospital: An Eleven-year Review.

This study provides region-specific pediatric IBD data from the Philippines, highlighting prevalence of very-early-onset disease, perianal involvement in Crohn's, and factors (diagnostic delay, wasting, pancolitis)...

Read Summary
Nutrition management and self-perceived relapse triggers in patients with inflammatory bowel disease: results from the 3R web-based survey.
Crohn's & colitis 360

Nutrition management and self-perceived relapse triggers in patients with inflammatory bowel disease: results from the 3R web-based survey.

Patients with Crohn's reported more relapses and are more likely to see diet as a relapse trigger; nutritional therapy (including elemental diets) is used more often in Crohn's than UC in this Japanese sample. This...

Read Summary

Performance of the 2025 ASAS-Spartan Revised Classification Criteria for Axial Spondyloarthritis in a Canadian Multicenter Inception Cohort with Psoriasis, Uveitis, or Colitis Presenting with Undiagnosed Back Pain

The criteria were tested specifically in patients with psoriasis, uveitis, or IBD presenting with chronic back pain—groups at higher risk of axSpA—so results inform how well the new criteria perform in these real‑world...

Read Summary

Screening Tools for Spondyloarthropathies Among Patients with Inflammatory Bowel Disease: A Scoping Review

SpA is a frequent but underrecognized extraintestinal manifestation in people with IBD; validated screening tools can help identify patients who need rheumatology evaluation. Earlier detection may address joint symptoms...

Read Summary
An Observational Prospective Long-term Exposure Registry of Adult Patients With Moderate-to-Severe Ulcerative Colitis
ClinicalTrials.gov

An Observational Prospective Long-term Exposure Registry of Adult Patients With Moderate-to-Severe Ulcerative Colitis

Long-term safety data on biologics and thiopurines are important for people with ulcerative colitis because they help patients and clinicians weigh risks (including malignancies and pregnancy-related outcomes) when...

Read Summary
Disability among Palestinian patients with inflammatory bowel disease: evaluation using the IBD Disk and identification of associated factors.
Crohn's & colitis 360

Disability among Palestinian patients with inflammatory bowel disease: evaluation using the IBD Disk and identification of associated factors.

Disability related to IBD affects daily functioning and quality of life; identifying factors linked with higher or lower disability (vitamin D status, azathioprine use, smoking) can help patients and clinicians consider...

Read Summary
Psychosocial Experience, Impacts and Management of Fatigue in Young People With Inflammatory Bowel Disease—A Systematic Review
JCC Plus

Psychosocial Experience, Impacts and Management of Fatigue in Young People With Inflammatory Bowel Disease—A Systematic Review

Fatigue is a common, impactful symptom in pediatric and young-adult IBD but is poorly defined and measured, limiting the ability to design age-appropriate supports. This review highlights gaps that affect patients' daily...

Read Summary
H7F ameliorates DSS-induced colitis through restoration of intestinal barrier function and inhibition of IL-17/NF-κb signaling.
Frontiers in pharmacology

H7F ameliorates DSS-induced colitis through restoration of intestinal barrier function and inhibition of IL-17/NF-κb signaling.

The study suggests a herbal formula (H7F) may protect intestinal barrier function, modulate the gut microbiome, and suppress IL-17/NF-κB inflammation in a mouse colitis model—mechanisms relevant to IBD pathophysiology.

Read Summary
Associations between multidimensional sleep health and inflammatory bowel disease onset and activity: A systematic review of the RU-SATED framework
World Journal of Psychiatry

Associations between multidimensional sleep health and inflammatory bowel disease onset and activity: A systematic review of the RU-SATED framework

Sleep disturbance is common in IBD and may relate to disease risk and flares. Understanding which sleep problems are linked to onset or activity could point to new ways to support people with IBD.

Read Summary
Exploratory Risk Patterns of Steroid Dependency in Ulcerative Colitis: A Multicenter Pilot Study Combining Logistic Regression and Self-Organizing Map Analysis.
Inflammatory intestinal diseases

Exploratory Risk Patterns of Steroid Dependency in Ulcerative Colitis: A Multicenter Pilot Study Combining Logistic Regression and Self-Organizing Map Analysis.

Steroid dependency affects many people with ulcerative colitis and can change long-term treatment plans. This study explores clinical factors and uses an AI clustering method to visualize different risk patterns, which...

Read Summary
Persistent disease burden despite advanced therapies in inflammatory bowel disease: a real-world patient-reported survey from Greece.
Frontiers in immunology

Persistent disease burden despite advanced therapies in inflammatory bowel disease: a real-world patient-reported survey from Greece.

Many people with IBD still experience active disease, poor quality of life, work impairment, and depression even while on advanced therapies — highlighting gaps in how we measure and manage treatment success. Who this...

Read Summary
Data-driven subphenotyping uncovers ulcerative colitis subtype with high risk for relapse in Japan: a prospective multicenter cohort study
The Lancet Regional Health - Western Pacific

Data-driven subphenotyping uncovers ulcerative colitis subtype with high risk for relapse in Japan: a prospective multicenter cohort study

The study suggests quality-of-life and patient-reported measures can reveal a subgroup of UC patients in clinical remission who nevertheless have higher relapse risk, which could help personalize monitoring and care.

Read Summary
Fecal incontinence among patients with ulcerative colitis and relation with disease activity, and extent: A cross-sectional study.
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology

Fecal incontinence among patients with ulcerative colitis and relation with disease activity, and extent: A cross-sectional study.

Fecal incontinence is a distressing symptom that lowers quality of life and appears linked to active disease in UC. Knowing which patients are at higher risk can help clinicians focus assessment and symptom support.

Read Summary
Serum immune profiling suggests overlap between IBD patients with joint complaints and patients with spondyloarthritis.
Frontiers in immunology

Serum immune profiling suggests overlap between IBD patients with joint complaints and patients with spondyloarthritis.

If you have IBD and joint symptoms, this study suggests your joint complaints may reflect measurable immune changes that partly overlap with spondyloarthritis, not just non-specific pain. That could mean joint symptoms...

Read Summary
Systemic antibody responses against bacterial and viral antigens associate with fatigue in patients with inflammatory bowel disease.
iScience

Systemic antibody responses against bacterial and viral antigens associate with fatigue in patients with inflammatory bowel disease.

Fatigue is a common, disabling symptom in people with IBD with unclear causes. Finding reproducible immune or infectious signatures related to fatigue could point toward new research directions and, eventually, markers...

Read Summary
Reduced fecal GP2 levels in ulcerative colitis associate with inflammatory activity and microbial composition.
Clinica chimica acta; international journal of clinical chemistry

Reduced fecal GP2 levels in ulcerative colitis associate with inflammatory activity and microbial composition.

If fecal GP2 reliably reflects UC activity and microbial changes, it could become a noninvasive marker to track inflammation or to study disease mechanisms that differ between UC and CD.

Read Summary
Assessment of kinesiophobia in ulcerative colitis: a case-control study highlighting functional and psychological implications.
Revista da Associacao Medica Brasileira (1992)

Assessment of kinesiophobia in ulcerative colitis: a case-control study highlighting functional and psychological implications.

Fear of movement was more common and more severe in people with ulcerative colitis in this study. Addressing kinesiophobia could help increase physical activity and improve function and quality of life for people with...

Read Summary
Symptom Management Experiences of People Living With Crohn's Disease Through a Journey Map: A Qualitative Study.
Journal of clinical nursing

Symptom Management Experiences of People Living With Crohn's Disease Through a Journey Map: A Qualitative Study.

A patient-centered journey map identifies changing symptom, psychological, and social needs at different stages of Crohn's disease. That can help clinicians and care teams target education, mental-health support, and...

Read Summary
Anti-inflammatory efficacy of diosgenin in an oxazolone-induced model of ulcerative colitis in mice via suppression of Th2 pathways and pSTAT3 expression: A prospective study.
Science progress

Anti-inflammatory efficacy of diosgenin in an oxazolone-induced model of ulcerative colitis in mice via suppression of Th2 pathways and pSTAT3 expression: A prospective study.

A natural compound (diosgenin) reduced disease signs and inflammatory markers in a mouse model of ulcerative colitis, suggesting a possible anti-inflammatory mechanism that could inform future preclinical research.

Read Summary
Disorders of Gut-Brain Interaction like symptoms in Children with Inflammatory Bowel Disease: A Multicenter Prospective Study from the Pediatric IBD Porto Group of the ESPGHAN.
The American journal of gastroenterology

Disorders of Gut-Brain Interaction like symptoms in Children with Inflammatory Bowel Disease: A Multicenter Prospective Study from the Pediatric IBD Porto Group of the ESPGHAN.

Children with IBD can have persistent gut–brain interaction symptoms even when inflammation is quiescent; these symptoms are linked with worse quality of life and higher anxiety. Recognizing DGBI-like symptoms may help...

Read Summary
Artemisia rupestris Improves the Microbiota–Barrier Axis in DSS Colitis
International Journal of Molecular Sciences

Artemisia rupestris Improves the Microbiota–Barrier Axis in DSS Colitis

The study suggests Artemisia rupestris extract can reduce inflammation, repair the intestinal barrier, and shift the gut microbiota and metabolites in a mouse colitis model — pathways that are important in IBD. These...

Read Summary
Synergistic synbiotic therapies for ulcerative colitis: mechanistic insights from multi-targeted pathways in animal models
Inflammopharmacology

Synergistic synbiotic therapies for ulcerative colitis: mechanistic insights from multi-targeted pathways in animal models

People with ulcerative colitis may be interested because synbiotic approaches aim to change the gut microbiome and intestinal barrier and therefore could become a future therapeutic option or adjunct. The paper...

Read Summary
Meta-analysis: safety and efficacy of ustekinumab in pediatric inflammatory bowel disease patients with anti-TNF failure.
BMC gastroenterology

Meta-analysis: safety and efficacy of ustekinumab in pediatric inflammatory bowel disease patients with anti-TNF failure.

This review pools available pediatric data showing ustekinumab can induce and maintain remission after anti‑TNF failure, offering a treatment option for children with refractory IBD. Results are most robust for Crohn’s...

Read Summary