Diarrhea, abdominal pain, fatigue, bleeding, urgency, flares, remission, and symptom management news.
Page 3 of 9 · 399 articles
A direct-vision push-type dilator (BougieCap) was used to safely dilate a low rectal stricture from Crohn's disease, allowing same-session sigmoidoscopy and biopsy and reported symptom improvement up to 18 months.
Obese patients with FibroScan-detected steatosis in this cohort had a high frequency of colitis and some cases of IBD, dysplasia, and cancer, which could affect screening and symptom evaluation decisions.
Fatigue is extremely common in IBD and is closely linked to depression—recognizing and addressing mental-health issues may be important for patients who report significant fatigue.
Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease, Inflammatory bowel disease, and CRP. The original article is from Journal of medical biochemistry.
Orofacial granulomatosis often co-occurs with Crohn's disease and appears linked to a distinct Crohn's phenotype and treatment needs. The findings suggest that advanced therapies can be effective for OFG-associated CD...
If disease activity hurts quality of life partly through low self-efficacy and (for UC) psychological distress, then boosting self-management confidence and identifying anxiety/depression could help improve...
A blood biomarker that flags higher risk for complicated Crohn's could help identify people who may need closer monitoring or earlier treatment escalation before clear symptoms or endoscopic inflammation appear.
VEO-IBD often presents with severe, extensive disease and can include monogenic causes and early hepatobiliary complications; knowing common presentations and early management patterns helps families and clinicians plan...
Based on the title and source metadata, this appears to be a clinical study related to Crohn's disease, Inflammatory bowel disease, and Capsule Endoscopy. The original article is from BMC Gastroenterology.
Delays and incomplete pre-referral screening are common in pediatric IBD and can affect how sick children are when they first see specialists. Better, standardized use of fecal calprotectin and abdominal ultrasound...
The study suggests a mechanism (reduced intestinal oxalate transport) that could make common “healthy” plant foods aggravate intestinal inflammation in some people with Crohn’s or ulcerative colitis, which could affect...
The study uses a mouse model of ulcerative colitis to test hemp seed oil and reports molecular and metabolic changes alongside reduced disease in the model. Patients and researchers may be interested because it explores...
The study suggests that asymptomatic C. difficile colonization may not predict return of IBD activity in patients who are in remission, which could influence how clinicians interpret positive C. difficile tests in people...
Many people with IBD have ongoing IBS-like symptoms despite little or no intestinal inflammation. This project targets brain–gut and autonomic mechanisms that might explain symptom persistence and tests a non-drug...
The paper identifies epothilone B as a repurposing candidate that may reduce neutrophil-driven inflammation and support epithelial healing in IBD models, a potential new strategy distinct from broad neutrophil...
The study suggests ED presentation symptoms predict admission differently in UC versus CD, which could affect triage and short-term risk assessment for IBD patients. Knowing which symptoms are stronger predictors by...
The study links IRF5 to worse intestinal inflammation in UC and shows that reducing IRF5 activity lessens disease in a mouse model, suggesting IRF5 could be a future therapeutic target or biomarker.
A blood biomarker that helps predict primary non-response to anti‑TNF drugs could spare some patients ineffective therapy, reduce delays to alternative treatments, and inform shared decision‑making before starting...
Based on the title and source metadata, this appears to be a patient education related to Crohn's disease, Inflammatory bowel disease, and Symptoms and flares. The original article is from Polish archives of internal...
Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Tests and monitoring. The original article is from Frontiers in immunology.
Dietary patterns may help reduce symptoms and improve quality of life for many people with ulcerative colitis and could influence inflammatory biomarkers and the gut microbiome, offering a nonpharmacologic adjunct to...
The study identifies a macrophage-driven mechanism (IL-1β–linked ferroptosis-like lipid peroxidation) that may contribute to epithelial injury in Crohn’s disease, suggesting new biological targets that could eventually...
Biopsy-based keratin patterns might help distinguish IBD, microscopic colitis, and IBS—conditions that can look similar clinically—so this could improve diagnostic accuracy if validated.
Many people with UC try dietary supplements; this randomized trial tested grape seed extract and found a measurable reduction in an inflammation blood marker (hs‑CRP) but no clear improvement in most other measured...
The paper identifies a molecular pathway (SERPINB5–MMP9–RLN2) by which the HDAC inhibitor trichostatin A reduced inflammation and protected the intestinal barrier in mouse and cell models of ulcerative colitis,...
Based on the title and source metadata, this appears to be a systematic review or meta analysis related to Ulcerative colitis, Inflammatory bowel disease, and Urgency. The original article is from Gastro hep advances.
Shows molecular correlates (reduced IL‑17 signaling and IL‑1β) linked with mucosal healing after exclusive enteral nutrition in children with Crohn's disease, which may help researchers develop biomarkers or understand...
The mucus layer and goblet cells are central to colonic barrier function; understanding goblet cell diversity and plasticity could point to new ways to restore the mucus barrier in UC and improve disease control.
Severe UC flares can produce extreme but reversible hyperglycemia that may look like new-onset diabetes, so patients and clinicians should monitor and re-evaluate glucose over time rather than assuming a permanent...
The study suggests a common plant compound (oxalate) may build up in the intestines of people with IBD because transporter proteins are reduced, potentially worsening inflammation. If confirmed, this could influence...
This study identifies a specific gut microbe (Turicimonas muris) and an immune pathway link by which a high-fat diet reduced experimental colitis severity in mice, suggesting diet–microbiome interactions can strongly...
Depression and GI diseases often co-occur; knowing which tends to appear first — and that this varies by subtype — can help clinicians prioritize screening and integrated care.
Genetic variation in MYO9B has been linked to Crohn’s disease, ulcerative colitis, and celiac disease. This study suggests a plausible epithelial-cell mechanism — altered microvilli and RhoA signaling — that could help...
Many people with IBD remain symptomatic even when tests show little or no inflammation; recognising these persistent symptoms as a separate treatment target could improve quality of life. This reframes care to address...
ITB can closely mimic Crohn’s disease, so this study is relevant because it describes diagnostic test yields and illustrates that targeted TB testing and therapeutic trials of antituberculosis treatment can help...
IL-22 links microbial metabolites to epithelial repair and inflammation; clarifying these pathways could inform future therapies or dietary/microbiome approaches to promote mucosal healing without worsening inflammation.
Patients who present with new radiologic terminal ileitis sometimes develop Crohn’s disease. Identifying simple blood and imaging markers that predict who is at higher risk could help prioritize follow-up or specialist...
Identifies a molecule (CCL3) linked to more severe inflammation in IBD tissues, which could help researchers develop new biomarkers or treatments targeting immune-cell recruitment and polarization.
The study connects a bothersome UC symptom (bowel urgency) to intestinal ultrasound signs of transmural inflammation, suggesting ultrasound might help explain and track symptom-related inflammation without relying solely...
People with IBD are often interested in how dietary fibers and the microbiome might influence inflammation.
C. difficile can cause or complicate diarrhoea in children with IBD, so understanding test positivity in this group helps clinicians interpret results and decide when to investigate or treat. The study suggests...
The study identifies a β-glucan → IL-33 → active eosinophil pathway that reduced colitis in a mouse model, suggesting a novel immunomodulatory mechanism that could inform future IBD research.
The study suggests a hidden, early molecular defect that leaves intestinal cells primed to die even during clinical remission, which could help explain why flares recur. Measuring these molecular signals might eventually...
Intestinal barrier dysfunction is a likely driver of inflammation and flares in ulcerative colitis, so therapies that restore barrier integrity could help reduce disease activity and recurrence. This review highlights...
A controlled trial found low-dose naltrexone did not induce endoscopic or clinical remission in Crohn's disease, but it showed a possible benefit for reducing fatigue. Patients seeking symptom relief without...
Researchers found that nearly all people with UC have high-titer autoantibodies to the epithelial integrin αvβ6 that can precede disease and associate with worse outcomes. Understanding whether and how these antibodies...
Oral and upper-GI involvement in Crohn's can be missed and may change how disease is diagnosed and managed. A focused review helps clinicians and researchers spot gaps in diagnostics and treatment research.
Patients with IBD often have joint and skin comorbidities that drive symptoms and treatment choices.
