Colonoscopy, endoscopy, fecal calprotectin, CRP, imaging, intestinal ultrasound, and monitoring research.
Page 18 of 33 · 1561 articles
Automated, annotation‑efficient lesion segmentation could speed image review and reduce labeling costs for Crohn’s disease imaging research and tool development. If robust, it may help create better AI tools to support...
Regional data can reveal how IBD presents and behaves locally; that information helps clinicians with earlier recognition and tailoring care and helps researchers compare geographic phenotypes.
Perianal fistulas are a common and morbid complication of Crohn's disease in children; a reliable, less burdensome imaging tool could help assess severity and monitor response to therapy more often than MRI.
This model could improve how researchers study IBD inflammation and early colorectal cancer in a human-derived, multicellular system that reproduces neuromuscular function and immune responses. That may speed preclinical...
IBD patients can have lung involvement without symptoms. Simple spirometry focused on small-airway measures might help detect early pulmonary changes and prompt further evaluation or monitoring.
People with CGD commonly have liver involvement and some develop IBD-like intestinal disease; recognizing and monitoring these complications may affect care and outcomes.
The study links worse UC activity with higher rates of anxiety and depression and with poorer quality of life among patients in Pakistan, suggesting mental-health screening could be relevant to overall disease...
People receiving immune checkpoint inhibitors who develop colitis may face different risks of needing stronger immunosuppression depending on the ICI drug class. Understanding which features predict escalation could...
Dietary components and processed vegetarian/vegan products may alter the gut microbiome and intestinal barrier — both are relevant to IBD. This study will directly compare common vegan products and meat substitutes with...
Noninvasive blood indices are appealing because they’re easier than colonoscopy. This study tests whether two such indices (SII and HALP) reliably reflect endoscopic activity in ulcerative colitis and whether...
The study proposes new biomarker candidates (C5AR1, KDM2A, HCAR3) and microbiota-derived metabolites that might interact with those targets. If validated, that could guide future diagnostic tests or microbiome-targeted...
Distinguishing IBD from gastrointestinal tuberculosis is challenging in regions where GITB is common; histologic markers like basal plasmacytosis and eosinophilia on mucosal biopsy could help guide diagnosis when...
Researchers are exploring new small molecules that might modulate T cells in IBD. This study found lab evidence of T‑cell inhibition for several compounds but no therapeutic benefit in a mouse colitis model, so these...
Improving accuracy of IBD case identification in EMRs can make research and registries more reliable, reduce misclassification, and help ensure studies and quality programs use the right patient groups.
If validated, IGFBP5 or its downstream pathway could help predict who will not respond to anti-TNF therapy and point to new targets to overcome resistance.
Rising IBD prevalence across Asia means more people will need diagnosis, long-term care, and health-system resources; patterns differ by country and by Crohn's disease versus ulcerative colitis, which affects planning...
Quantitative, rapid stool tests could make it easier to track intestinal inflammation without central lab delays. If translated to clinical use, SERS-enhanced lateral-flow assays might allow more frequent, point-of-care...
The study points to serum protein panels and tissue expression of glypican-6 (GPC6) as potential tools to diagnose or predict intestinal strictures in Crohn disease, which could help detect fibrosis earlier and guide...
A blood test that more reliably distinguishes UC from CD could reduce diagnostic uncertainty and help guide appropriate long‑term management for people with colonic inflammatory bowel disease.
The study will test whether routine point‑of‑care intestinal ultrasound changes clinical decisions compared with standard monitoring, which could make monitoring less invasive and more responsive if effective.
Researchers are testing whether targeting fungi with fluconazole can boost how well IL-23 biologics work for Crohn’s disease — if positive, this could point to a new adjunctive strategy to improve responses to biologic...
The trial could show whether a smart-label app plus clinician alerts improves medication adherence and downstream clinical outcomes for people with Crohn's disease or ulcerative colitis starting oral or subcutaneous...
Researchers are testing whether baseline fecal microbiome profiles can predict who with mild ulcerative colitis will benefit from a specific prebiotic supplement. If validated, this approach could move dietary therapy...
The study suggests acetate (sodium acetate) can protect intestinal cells and reshape the gut microbiota in preclinical models of ulcerative colitis, pointing to a potential microbiome-linked therapeutic avenue that might...
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People with IBD or Crohn's disease considering or taking upadacitinib may worry about rare but serious risks such as heart attacks, strokes, or blood clots. This meta-analysis found no clear increase in those events...
This real-world multicentre study evaluates risankizumab effectiveness and short-term persistence in adults with Crohn's disease, including those previously treated with ustekinumab — information that can help patients...
The study suggests abdominal fat percentage (by DXA) is associated with fracture history in people with IBD, even after accounting for BMI, BMD, and lean mass. If confirmed prospectively, regional fat measures could help...
A new chemiluminescent probe may help researchers detect and visualize peroxynitrite, a reactive species linked to inflammation in ulcerative colitis, which could aid research into disease mechanisms and early detection...
People with IBD on biologics or small molecules who live in or travel to areas where Coccidioides is endemic face a measurable risk of coccidioidomycosis. How the infection is classified (proven/probable/possible)...
The study tests a new mechanism (TL1A inhibition) that may reduce inflammation and fibrosis in IBD. Positive phase 2b results suggest duvakitug could become another treatment option if later trials confirm benefit and...
The study introduces a phylogeny-aware AI method that may improve detection and interpretation of microbiome signatures linked to IBD and colorectal cancer, which could help research into microbial biomarkers relevant to...
If your colonoscopy found inflammation only in the terminal ileum, additional imaging with CTE identified more proximal small-bowel disease in about half of patients and often led to a diagnosis of Crohn’s disease.
If validated, blood protein signatures that appear years before symptoms could help identify people at higher risk of Crohn’s disease and point to lifestyle or dietary measures that alter early biology.
Depression is common in people with IBD and can worsen quality of life and disease outcomes. This trial explores whether mirtazapine—an antidepressant thought to have favorable gastrointestinal tolerability—can be...
This analysis suggests upadacitinib works and has a similar safety and pharmacokinetic profile in East Asian patients with moderately to severely active ulcerative colitis as in the global trials, which may reassure...
A new molecular finding (PTPRK::RSPO3 fusion) in a serrated colorectal lesion from a person with ulcerative colitis may be relevant to understanding dysplasia and cancer pathways in IBD, and could prompt further study of...
Coexistence of ulcerative colitis and collagenous colitis is rare but can change diagnosis and management. Stool calprotectin and biopsies helped identify and monitor disease activity, and adjusting mesalazine coincided...
Using TDM to optimize vedolizumab could improve outcomes but may raise treatment costs; patients and clinicians should know cost-effectiveness depends heavily on drug price and local healthcare thresholds.
Standardized intestinal ultrasound scoring could help non-invasively monitor Crohn’s disease activity and reduce reliance on colonoscopy for some assessments. A high-sensitivity IUS score may be useful to rule out...
Anemia is a common complication of IBD and can worsen quality of life. This study suggests endotoxins leaking from an inflamed gut may drive anemia through TLR4 on tissue-resident macrophages, highlighting a possible new...
Auto-brewery syndrome can cause unexplained intoxication-like symptoms and may be under-recognized in people with Crohn’s disease. Recognizing gut fermentation as a possible cause can affect diagnostic testing and...
Accurate measurement of physical activity matters because it’s linked to symptoms, fitness, and overall health.
Many women with UC use hormonal contraception and worry it might worsen disease activity. This study provides evidence that HCT was not linked to more recurrent flares or higher cumulative inflammatory burden in the...
Accurate, reliable measurement of ulcers and polyps during endoscopy can improve disease assessment and tracking for people with Crohn’s disease and ulcerative colitis and may better align visual findings with symptoms...
Diagnosis between UC, Crohn’s disease, and unclassified IBD can change in a meaningful minority of patients over years. Awareness of common reasons for reclassification (segmental disease, strictures) helps guide...
Sarcopenia (low muscle mass) was linked with worse outcomes in Crohn’s disease and, combined with fecal calprotectin and disease behaviour, formed a score that better predicted unfavourable courses. Identifying at-risk...
People with ulcerative colitis taking etrasimod may have higher drug levels if they have certain CYP2C9 genotypes or significant liver impairment; dose adjustments could be needed to avoid increased exposure.
