Article Archive

Page 71 of 100 · 4799 patient-friendly summaries

Spatial genetic mapping links shared inflammatory bowel disease liability to adult immune-epithelial lesion contexts.
Frontiers in immunology

Spatial genetic mapping links shared inflammatory bowel disease liability to adult immune-epithelial lesion contexts.

Links between IBD genetic risk and specific adult tissue lesion contexts help researchers understand which cell types and tissue programs may mediate inherited susceptibility. That can guide future biomarker and...

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Effectiveness and Safety of Risankizumab in Crohn Disease After Failure of a First Line of Advanced Therapy: A Long-Term, Real-Life Study.
American journal of therapeutics

Effectiveness and Safety of Risankizumab in Crohn Disease After Failure of a First Line of Advanced Therapy: A Long-Term, Real-Life Study.

This real-world, multicenter study suggests risankizumab can induce clinical and steroid-free remission and mucosal healing in many patients with Crohn disease who previously failed advanced therapies, which may be...

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Classifications of rheumatological extraintestinal manifestations in inflammatory bowel disease: Unmet needs in clinical practice and trials.
Inflammatory bowel diseases

Classifications of rheumatological extraintestinal manifestations in inflammatory bowel disease: Unmet needs in clinical practice and trials.

Rheumatological EIMs (notably joint inflammation) are frequent in IBD and affect quality of life; inconsistent definitions and lack of validated PROs make it harder for patients and clinicians to understand and compare...

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Antibiotic Class-Specific Effects on Inflammatory Bowel Disease: Microbiome Disruption, Risk, and Recovery
International Journal of Molecular Sciences

Antibiotic Class-Specific Effects on Inflammatory Bowel Disease: Microbiome Disruption, Risk, and Recovery

Antibiotics can change the gut microbiome in ways that may raise IBD risk or worsen disease for some people. Knowing which antibiotic classes and approaches may be less harmful could help patients and clinicians reduce...

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Expression patterns of miR-21 and miR-146 in ulcerative colitis: implications for disease progression and therapeutic strategies
Journal of Genetic Engineering and Biotechnology

Expression patterns of miR-21 and miR-146 in ulcerative colitis: implications for disease progression and therapeutic strategies

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Journal of Genetic...

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A Study Investigating Oral Ozanimod (RPC1063) in Pediatric Participants With Moderate to Severe Active Ulcerative Colitis
ClinicalTrials.gov

A Study Investigating Oral Ozanimod (RPC1063) in Pediatric Participants With Moderate to Severe Active Ulcerative Colitis

This trial explores whether oral ozanimod can induce and maintain remission in children and adolescents with moderate to severe ulcerative colitis who have not responded to standard therapies. Pediatric-specific evidence...

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An Early-Stage Study in Multiple Clinics of How Afimkibart May Affect the Body's Processing of Medicines That Rely on Cytochrome P450 Enzymes in Participants With Ulcerative Colitis
ClinicalTrials.gov

An Early-Stage Study in Multiple Clinics of How Afimkibart May Affect the Body's Processing of Medicines That Rely on Cytochrome P450 Enzymes in Participants With Ulcerative Colitis

Patients with UC often take multiple medicines that rely on CYP enzymes. This study is checking if afimkibart affects how those drugs are processed, which could matter for safety or dosing if the drug proceeds in...

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Development and External Validation of a Machine Learning Model for Pre-Endoscopic Prediction of Montreal Disease Extent (E1/E2/E3) in Ulcerative Colitis Using Symptoms, Signs, and Laboratory Tests: A Multicenter Retrospective Observational Study
ClinicalTrials.gov

Development and External Validation of a Machine Learning Model for Pre-Endoscopic Prediction of Montreal Disease Extent (E1/E2/E3) in Ulcerative Colitis Using Symptoms, Signs, and Laboratory Tests: A Multicenter Retrospective Observational Study

A validated pre-endoscopic model could help estimate UC disease extent before colonoscopy, aiding clinical triage and planning without replacing endoscopy.

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Predictive Efficacy of Fecal Calprotectin Assay by Magnetic Particle Chemiluminescence for Mucosal Healing in Moderate-to-Severe Ulcerative Colitis Patients Undergoing Initial Biologic Therapy(PRECAL)
ClinicalTrials.gov

Predictive Efficacy of Fecal Calprotectin Assay by Magnetic Particle Chemiluminescence for Mucosal Healing in Moderate-to-Severe Ulcerative Colitis Patients Undergoing Initial Biologic Therapy(PRECAL)

If validated, an early drop in fecal calprotectin could help identify patients on biologic therapy who are likely to achieve mucosal healing without waiting for invasive endoscopy, allowing earlier decisions about...

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Developing a Self-Management Intervention to Improve Health Outcomes for Patients With Inflammatory Bowel Disease
ClinicalTrials.gov

Developing a Self-Management Intervention to Improve Health Outcomes for Patients With Inflammatory Bowel Disease

Digital self-management programs could help people with active IBD build skills to manage symptoms and quality of life between clinic visits. This trial tests whether such a program is feasible, acceptable, and practical...

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Subcutaneous infliximab in the treatment of patients with perianal fistulizing Crohn's disease: current evidence and emerging roles.
Therapeutic advances in gastroenterology

Subcutaneous infliximab in the treatment of patients with perianal fistulizing Crohn's disease: current evidence and emerging roles.

Perianal fistulizing Crohn's disease is a disabling complication; a subcutaneous form of infliximab could lower treatment burden and expand options if its effectiveness and safety in this specific setting are confirmed.

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Patient Preferences for Inflammatory Bowel Disease Treatment: Results from a Global Survey Conducted in Partnership with the European Federation of Crohn’s & Ulcerative Colitis Associations
The Patient - Patient-Centered Outcomes Research

Patient Preferences for Inflammatory Bowel Disease Treatment: Results from a Global Survey Conducted in Partnership with the European Federation of Crohn’s & Ulcerative Colitis Associations

This global survey shows that people with IBD prioritize symptom relief and psychological well-being over treatment features like administration route or speed of onset. That matters for shared decision-making, trial...

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Spatiotemporally optimized heterotopic transplantation of early-stage small intestinal organoids ameliorates murine ulcerative colitis.
International immunopharmacology

Spatiotemporally optimized heterotopic transplantation of early-stage small intestinal organoids ameliorates murine ulcerative colitis.

If organoid transplantation can be translated to people, it could offer a new way to repair inflamed colonic lining and promote mucosal healing when current therapies are insufficient. The approach also highlights links...

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Reduced fecal GP2 levels in ulcerative colitis associate with inflammatory activity and microbial composition.
Clinica chimica acta; international journal of clinical chemistry

Reduced fecal GP2 levels in ulcerative colitis associate with inflammatory activity and microbial composition.

If fecal GP2 reliably reflects UC activity and microbial changes, it could become a noninvasive marker to track inflammation or to study disease mechanisms that differ between UC and CD.

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New Diagnostic Criteria for Acute Severe Ulcerative Colitis in the Modern Treatment Era: A Modified Delphi Consensus by REFINED-ASUC.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

New Diagnostic Criteria for Acute Severe Ulcerative Colitis in the Modern Treatment Era: A Modified Delphi Consensus by REFINED-ASUC.

The 1955 Truelove and Witts criteria do not account for patients already on modern outpatient therapies. Updated consensus criteria could change how ASUC is recognized and triaged in current clinical practice.

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Yiyi Fuzi Baijiang formula protects against DSS-induced colitis by orchestrating the gut barrier-microbiota-metabolism axis
Chinese Medicine

Yiyi Fuzi Baijiang formula protects against DSS-induced colitis by orchestrating the gut barrier-microbiota-metabolism axis

The study suggests a multi-component herbal formula may affect inflammation, the intestinal barrier, epithelial repair, the gut microbiome, and fecal metabolites in a mouse colitis model—topics relevant to understanding...

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SR9009 regulates macrophage polarization via the NR1D1/NF-κB axis to ameliorate obesity-associated ulcerative colitis
Frontiers in Gastroenterology

SR9009 regulates macrophage polarization via the NR1D1/NF-κB axis to ameliorate obesity-associated ulcerative colitis

This study identifies NR1D1 activation by the experimental drug SR9009 as a potential way to reduce inflammation and improve colon pathology in a mouse model of obesity-associated ulcerative colitis.

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Transitional care in pediatric inflammatory bowel disease: current strategies and future directions - a narrative review.
Przeglad gastroenterologiczny

Transitional care in pediatric inflammatory bowel disease: current strategies and future directions - a narrative review.

Transition from pediatric to adult IBD care is a high-risk period; structured programs and better communication can improve adherence and reduce relapse and hospitalization risk for young people with IBD.

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Multicentre retrospective real-world evidence study evaluating the effectiveness and safety of mirikizumab in patients with moderately to severely active ulcerative colitis.
Przeglad gastroenterologiczny

Multicentre retrospective real-world evidence study evaluating the effectiveness and safety of mirikizumab in patients with moderately to severely active ulcerative colitis.

Real-world data show how mirikizumab performs outside clinical trials, especially in patients previously exposed to multiple advanced therapies. That can help patients and clinicians weigh expectations for effectiveness...

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Assessment of kinesiophobia in ulcerative colitis: a case-control study highlighting functional and psychological implications.
Revista da Associacao Medica Brasileira (1992)

Assessment of kinesiophobia in ulcerative colitis: a case-control study highlighting functional and psychological implications.

Fear of movement was more common and more severe in people with ulcerative colitis in this study. Addressing kinesiophobia could help increase physical activity and improve function and quality of life for people with...

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Effectiveness of tofacitinib as rescue therapy in biological-naive patients with steroid-refractory acute severe ulcerative colitis: a multicentric retrospective analysis.
European journal of gastroenterology & hepatology

Effectiveness of tofacitinib as rescue therapy in biological-naive patients with steroid-refractory acute severe ulcerative colitis: a multicentric retrospective analysis.

This study suggests tofacitinib may work quickly as a rescue option for biologic‑naive patients with steroid‑refractory ASUC and that many achieved steroid‑free remission by 24 weeks — information that could matter when...

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Association between life satisfaction and selected socio-demographic factors and social and professional activity - a comparative study between patients with Crohn's disease and patients with ulcerative colitis.
Przeglad gastroenterologiczny

Association between life satisfaction and selected socio-demographic factors and social and professional activity - a comparative study between patients with Crohn's disease and patients with ulcerative colitis.

Life satisfaction and social/work impacts are central to daily functioning for people with IBD. Knowing which social factors relate to lower satisfaction can help patients, caregivers, and clinicians spot who may need...

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Remission duration according to dietary adherence in paediatric mild to moderate Crohn's disease treated with CDED + PEN.
Przeglad gastroenterologiczny

Remission duration according to dietary adherence in paediatric mild to moderate Crohn's disease treated with CDED + PEN.

Dietary therapy (CDED + PEN) was associated with longer remission when families adhered well; since adherence varies, support from a dietitian matters for keeping children in remission.

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Drug-associated inflammatory bowel disease: a real-world pharmacovigilance study using the FAERS and JADER databases.
Frontiers in immunology

Drug-associated inflammatory bowel disease: a real-world pharmacovigilance study using the FAERS and JADER databases.

This paper systematically catalogs drugs that have been reported with new or worsening IBD in two large pharmacovigilance databases. Knowing which medications generate strong reporting signals can help clinicians and...

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Symptom Management Experiences of People Living With Crohn's Disease Through a Journey Map: A Qualitative Study.
Journal of clinical nursing

Symptom Management Experiences of People Living With Crohn's Disease Through a Journey Map: A Qualitative Study.

A patient-centered journey map identifies changing symptom, psychological, and social needs at different stages of Crohn's disease. That can help clinicians and care teams target education, mental-health support, and...

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Ferulic acid - A promising candidate molecule for the treatment of colitis.
European journal of microbiology & immunology

Ferulic acid - A promising candidate molecule for the treatment of colitis.

People with ulcerative colitis may be interested because ferulic acid is a plant-derived compound that, in lab and animal studies, appears to reduce gut inflammation, support the intestinal barrier, and positively...

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