Article Archive

Page 48 of 100 · 4787 patient-friendly summaries

A comparative evaluation of new prebiotic candidates. Part 2: In vitro assays using faecal inoculum from IBD patients.
Food research international (Ottawa, Ont.)

A comparative evaluation of new prebiotic candidates. Part 2: In vitro assays using faecal inoculum from IBD patients.

Prebiotics change how gut microbes ferment carbohydrates and produce metabolites that can affect gut health. For people with IBD, a prebiotic that is well fermented by their microbiota, increases beneficial bacteria and...

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Structural characterization of an α-glucan from Dendrobium officinale and its gut microbiota-dependent protective effects against DSS-induced ulcerative colitis in mice.
Food research international (Ottawa, Ont.)

Structural characterization of an α-glucan from Dendrobium officinale and its gut microbiota-dependent protective effects against DSS-induced ulcerative colitis in mice.

The work highlights a dietary polysaccharide that reduced inflammation and improved mucosal barrier function in a mouse colitis model through gut-microbiota changes — a mechanism relevant to IBD research and potential...

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Superb microvascular imaging within intestinal ultrasonography predicts endoscopic ulcers in the terminal ileum of patients with Crohn's disease.
Medicine

Superb microvascular imaging within intestinal ultrasonography predicts endoscopic ulcers in the terminal ileum of patients with Crohn's disease.

Noninvasive intestinal ultrasound with superb microvascular imaging (SMI) may help predict the presence and size of endoscopic ulcers in the terminal ileum of people with Crohn’s disease. That could improve noninvasive...

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Tetrastigma hemsleyanum polysaccharides ameliorate inflammatory bowel disease via sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 -mediated gut vascular barrier repair.
Phytomedicine : international journal of phytotherapy and phytopharmacology

Tetrastigma hemsleyanum polysaccharides ameliorate inflammatory bowel disease via sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 -mediated gut vascular barrier repair.

This preclinical study suggests a plant-derived polysaccharide (THP) can repair the gut vascular barrier and reduce inflammation in experimental colitis via the S1P/S1PR2 pathway, pointing to a novel potential target for...

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Regulatory mechanisms and therapeutic targets of programmed cell death in intestinal epithelial cells in inflammatory bowel disease.
Tissue & cell

Regulatory mechanisms and therapeutic targets of programmed cell death in intestinal epithelial cells in inflammatory bowel disease.

Understanding how different forms of programmed cell death in the gut lining contribute to barrier loss and inflammation could point to new therapeutic targets for IBD. The review also flags natural products and...

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P1.050. Esophageal Ulceration in Suspected Gastrointestinal Behçet Disease: A Diagnostic Challenge
Diseases of the Esophagus

P1.050. Esophageal Ulceration in Suspected Gastrointestinal Behçet Disease: A Diagnostic Challenge

Unexplained mid‑esophageal ulcers with recurrent oral ulcers can reflect rare systemic inflammatory diseases such as gastrointestinal Behçet disease, and they often need broad testing to exclude infections, malignancy,...

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Protective Effect of a Heat-Stabilized Bacteria Probiotic Preparation (VSL#3-HS) in a Mouse Model of Ulcerative Colitis Induced by Dextran Sulfate Sodium.
Molecular nutrition & food research

Protective Effect of a Heat-Stabilized Bacteria Probiotic Preparation (VSL#3-HS) in a Mouse Model of Ulcerative Colitis Induced by Dextran Sulfate Sodium.

If you follow IBD research, this study suggests a heat-stabilized (nonviable) multi-strain bacterial product reduced inflammation and improved some disease measures in a mouse model of ulcerative colitis — a step that...

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Aminosalicylate use Increases Corticosteroid Exposure and Decreases Biologic Durability in Pediatric Crohn's Disease.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Aminosalicylate use Increases Corticosteroid Exposure and Decreases Biologic Durability in Pediatric Crohn's Disease.

This study suggests that using 5‑ASA drugs early in children with Crohn’s disease was common but linked to more steroid use, delayed biologic treatment, and lower biologic durability — outcomes that matter for long‑term...

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Using a Person-Centred Approach to Adapt a Digital Therapy for Inflammatory Bowel Disease (COMPASS-IBD).
Health expectations : an international journal of public participation in health care and health policy

Using a Person-Centred Approach to Adapt a Digital Therapy for Inflammatory Bowel Disease (COMPASS-IBD).

People with IBD often face mental-health challenges, stigma and unpredictability of symptoms. Adapting an established CBT-based digital programme with direct input from patients and clinicians can make the content more...

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Self-Propelling WO3 Nanomotors Restore the Gut-Kidney Axis by Modulating Intestinal Homeostasis in Inflammatory Bowel Disease.
Advanced healthcare materials

Self-Propelling WO3 Nanomotors Restore the Gut-Kidney Axis by Modulating Intestinal Homeostasis in Inflammatory Bowel Disease.

The study presents a novel nanomaterial approach that aims to protect both inflamed intestines and kidneys by restoring intestinal barrier function and microbiome balance—mechanisms relevant to IBD-related systemic...

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Association Between Primary Sclerosing Cholangitis and Faecal Calprotectin Levels in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Cureus

Association Between Primary Sclerosing Cholangitis and Faecal Calprotectin Levels in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

People with IBD and coexisting primary sclerosing cholangitis (PSC) may get faecal calprotectin tests to monitor colon inflammation. If PSC raises FC independently of colitis, FC could mislead decisions about IBD...

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NUDT15 c.415C>T (rs116855232) Allele Frequency and Estimated Thiopurine Metabolizer Phenotype Distribution in the Iranian Population: A Study Based on Public Genomic Data
Europe PMC

NUDT15 c.415C>T (rs116855232) Allele Frequency and Estimated Thiopurine Metabolizer Phenotype Distribution in the Iranian Population: A Study Based on Public Genomic Data

NUDT15 variants strongly affect how people metabolize thiopurine drugs used in IBD; knowing variant frequency helps decide whether routine pre-treatment genotyping is useful in Iran and among specific ethnic groups.

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Microbial and functional shifts between flare and remission in a single-center cohort of children with inflammatory bowel disease.
World journal of clinical pediatrics

Microbial and functional shifts between flare and remission in a single-center cohort of children with inflammatory bowel disease.

The study links changes in gut microbes and microbial functions with disease activity in children with IBD, suggesting the microbiome may play a role in recovery and could be a target to help sustain remission.

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Target Relocalization-Driven Weakly Supervised Segmentation for Crohn's Disease via Auxiliary Anatomical Priors
Europe PMC

Target Relocalization-Driven Weakly Supervised Segmentation for Crohn's Disease via Auxiliary Anatomical Priors

Automated, annotation‑efficient lesion segmentation could speed image review and reduce labeling costs for Crohn’s disease imaging research and tool development. If robust, it may help create better AI tools to support...

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Ultrasound Features Associated with Activity of Perianal Fistulas in Pediatric Patients with Crohn's Disease.
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

Ultrasound Features Associated with Activity of Perianal Fistulas in Pediatric Patients with Crohn's Disease.

Perianal fistulas are a common and morbid complication of Crohn's disease in children; a reliable, less burdensome imaging tool could help assess severity and monitor response to therapy more often than MRI.

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A Centimeter-Scale, Peristaltic Human Intestinal Organoid with Integrated Neuro-Immune-Vascular Systems Recapitulates Enteritis and Orthotopic Colorectal Cancer
Europe PMC

A Centimeter-Scale, Peristaltic Human Intestinal Organoid with Integrated Neuro-Immune-Vascular Systems Recapitulates Enteritis and Orthotopic Colorectal Cancer

This model could improve how researchers study IBD inflammation and early colorectal cancer in a human-derived, multicellular system that reproduces neuromuscular function and immune responses. That may speed preclinical...

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Probiotic-based sequential delivery system for gut-brain co-therapy against inflammatory bowel disease-associated anxiety/depression
Journal of Nanobiotechnology

Probiotic-based sequential delivery system for gut-brain co-therapy against inflammatory bowel disease-associated anxiety/depression

The study presents a novel probiotic-based delivery system that targets both intestinal inflammation and anxiety/depression through the gut–brain axis, a potentially relevant concept for people with IBD who commonly...

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Living with Primary Immunodeficiencies: CVID—Enteropathy from the Perspective of a Gastroenterologist
Journal of Human Immunity

Living with Primary Immunodeficiencies: CVID—Enteropathy from the Perspective of a Gastroenterologist

CVID-related enteropathy can resemble celiac disease or IBD, carries high morbidity and mortality, and often does not respond to standard immunoglobulin therapy — patients and clinicians need awareness of its distinct...

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Nursing‐Led Support Across the Standard Care–Clinical Trial–Standard Care Pathway in Inflammatory Bowel Disease: A Review With Realist‐Informed Interpretation
PubMed Central

Nursing‐Led Support Across the Standard Care–Clinical Trial–Standard Care Pathway in Inflammatory Bowel Disease: A Review With Realist‐Informed Interpretation

Improving nursing support during IBD trial pathways could help people stay engaged, understand what participation involves, and report problems earlier—potentially making trials safer and more equitable.

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Evaluation of subclinical pulmonary involvement in inflammatory bowel disease using spirometry: an observational study
Egyptian Journal of Bronchology

Evaluation of subclinical pulmonary involvement in inflammatory bowel disease using spirometry: an observational study

IBD patients can have lung involvement without symptoms. Simple spirometry focused on small-airway measures might help detect early pulmonary changes and prompt further evaluation or monitoring.

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Association between Ulcerative Colitis, mental health, and Quality of Life in a Pakistani cohort: A cross-sectional analysis
PLOS One

Association between Ulcerative Colitis, mental health, and Quality of Life in a Pakistani cohort: A cross-sectional analysis

The study links worse UC activity with higher rates of anxiety and depression and with poorer quality of life among patients in Pakistan, suggesting mental-health screening could be relevant to overall disease...

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Association of the ITGA4 rs1143674 polymorphism with subclinical atherosclerosis in patients with ulcerative colitis over 40 years of age
Almanac of Clinical Medicine

Association of the ITGA4 rs1143674 polymorphism with subclinical atherosclerosis in patients with ulcerative colitis over 40 years of age

People with UC face higher cardiovascular risk; this study links a specific ITGA4 genetic variant (rs1143674 CC) with subclinical atherosclerosis in UC patients over 40, which could help identify higher-risk individuals...

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Seasonality analysis of inflammatory bowel disease exacerbations requiring hospitalization: a single-center, retrospective study from Poland.
Polish archives of internal medicine

Seasonality analysis of inflammatory bowel disease exacerbations requiring hospitalization: a single-center, retrospective study from Poland.

Based on the title and source metadata, this appears to be a clinical study related to Inflammatory bowel disease and Symptoms and flares. The original article is from Polish archives of internal medicine.

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Blocking the m6Am methyltransferase PCIF1 in macrophages attenuates colitis progression by preventing neuronal damage.
Cellular & molecular immunology

Blocking the m6Am methyltransferase PCIF1 in macrophages attenuates colitis progression by preventing neuronal damage.

These results highlight a new cellular mechanism (macrophage-driven ECM changes) that may protect enteric neurons during intestinal inflammation — a process linked to symptoms and complications in IBD.

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AUF1-Engineered Intestinal Organoids Enhance Epithelial Barrier Repair and Mucosal Regeneration in Experimental Colitis
openRxiv

AUF1-Engineered Intestinal Organoids Enhance Epithelial Barrier Repair and Mucosal Regeneration in Experimental Colitis

The work links a specific post-transcriptional regulator (AUF1) to barrier dysfunction in UC and demonstrates that AUF1-restored organoids can enhance mucosal repair in mice, suggesting a possible new regenerative...

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Zataria multiflora Boiss Expression of Concern on "Benefits ofin Experimental Model of Mouse Inflammatory Bowel Disease".
Evidence-based complementary and alternative medicine : eCAM

Zataria multiflora Boiss Expression of Concern on "Benefits ofin Experimental Model of Mouse Inflammatory Bowel Disease".

Cure8 found this source from Evidence-based complementary and alternative medicine : eCAM, but the page could not be read reliably yet. It is tagged for Inflammatory bowel disease and Research and clinical trials. Open...

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Modulating immune toxicity in ulcerative colitis using a small molecule RAB27A inhibitor
Inflammatory Bowel Diseases

Modulating immune toxicity in ulcerative colitis using a small molecule RAB27A inhibitor

The report describes a novel small-molecule inhibitor (IMYX-3) targeting RAB27A to reduce neutrophil-mediated damage in ulcerative colitis models, which could point to a new therapeutic approach if later validated in...

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Clinical and endoscopic features of checkpoint inhibitor-induced colitis and their association with selective immunosuppressive therapy use.
Inflammatory bowel diseases

Clinical and endoscopic features of checkpoint inhibitor-induced colitis and their association with selective immunosuppressive therapy use.

People receiving immune checkpoint inhibitors who develop colitis may face different risks of needing stronger immunosuppression depending on the ICI drug class. Understanding which features predict escalation could...

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GLP-1 receptor agonist therapy is associated with increased symptomatic remission in ulcerative colitis: a matched cohort study.
Inflammatory bowel diseases

GLP-1 receptor agonist therapy is associated with increased symptomatic remission in ulcerative colitis: a matched cohort study.

This study suggests commonly used GLP-1 receptor agonists (semaglutide, liraglutide) were associated with higher symptomatic and endoscopic remission in ulcerative colitis compared with matched controls. If validated,...

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Inflammatory bowel disease treatment: Mechanisms to clinical translation (Review).
International journal of molecular medicine

Inflammatory bowel disease treatment: Mechanisms to clinical translation (Review).

The article reviews current and emerging IBD treatments and the biological reasons they may work — useful for patients wanting to understand treatment options and future directions. It highlights therapies beyond...

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Early‐life adverse events and risk of inflammatory bowel disease: A Scandinavian birth cohort study
Journal of Pediatric Gastroenterology and Nutrition

Early‐life adverse events and risk of inflammatory bowel disease: A Scandinavian birth cohort study

Parents and clinicians may wonder whether stressful events in early life increase a child’s long-term IBD risk. This large prospective study found no evidence that the measured early maternal or family adverse events...

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3 Self-Propelling WONanomotors Restore the Gut-Kidney Axis by Modulating Intestinal Homeostasis in Inflammatory Bowel Disease.
Advanced healthcare materials

3 Self-Propelling WONanomotors Restore the Gut-Kidney Axis by Modulating Intestinal Homeostasis in Inflammatory Bowel Disease.

This study describes a novel nanoparticle "nanomachine" approach aimed at fixing gut microbial and barrier dysfunction in IBD models and, by doing so, reducing secondary kidney injury—an intersection (gut–kidney axis)...

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