Fistulas, strictures, obstruction, anemia, cancer risk, extraintestinal symptoms, and related complications.
Page 13 of 20 · 922 articles
PSC occurring with IBD changes cancer risk and surveillance needs: patients can have extensive but asymptomatic colitis and a higher colorectal and biliary cancer risk. The review outlines gaps in diagnosis, monitoring,...
The review links macrophage-driven repair mechanisms to chronic inflammation and fibrosis in autoimmune diseases, including IBD, and highlights experimental strategies that aim to promote resolution rather than suppress...
This study evaluated whether blood levels of LRG track endoscopic and clinical disease activity in people with suspected UC or Crohn’s disease, which could point to a noninvasive inflammation biomarker.
Some people with IBD who have respiratory symptoms may have lasting problems with lung gas exchange even when their bowel disease is inactive. Knowing this can prompt clinicians to check lung function rather than...
This study helps distinguish patterns of colorectal dysplasia seen in people without IBD from those seen in IBD, which may affect how pathologists and clinicians interpret biopsy findings and consider cancer risk and...
People with IBD already face higher cardiovascular risk; drugs used to treat IBD (anti-TNF and JAK inhibitors) may differently affect small-vessel endothelial function, a possible contributor to heart and vascular...
People with Crohn’s or ulcerative colitis can rarely develop lung problems related to their disease or its treatments, and this review collates what is known about clinical features and therapies.
A person with Crohn disease on multiple immunosuppressive drugs was reported to have tracheobronchial wall thickening, an extraintestinal finding that could reflect infection or inflammation. This may be relevant for...
Based on the title and source metadata, this appears to be a case report related to Ulcerative colitis and Complications. The original article is from Cureus.
This research links a specific gut-associated yeast to activation of innate immune pathways (Dectin-1–Card9) that drive inflammatory signaling. For people with Crohn disease, it suggests fungal members of the gut...
FAP appears linked to both inflammation and fibrosis in IBD; distinguishing cellular versus extracellular FAP might help develop or validate fibrosis biomarkers that detect fibrostenotic disease.
Shorter height at IBD diagnosis was more common in Hispanic/Latino children and those without private insurance, which may reflect inequities in timely diagnosis and access to nutrition and care—issues that can affect...
FDA drug-label updates change how a medicine should be used and monitored. For people with ulcerative colitis and other immune-mediated diseases, this label highlights safety risks and limits on combining tofacitinib...
The appendix in conventional UC appears to be inflamed early and then remodels to fibrous obliteration over decades, which could influence thinking about timing or rationale for appendectomy-based interventions.
Older adults with UC face different risks and treatment trade-offs than younger patients — higher infection and cancer risks, medication toxicities, and challenges with diagnosis and colonoscopy. Understanding these...
The study links a common environmental pollutant (UV-328) to worsened experimental colitis and altered cholesterol metabolism, suggesting environmental exposures might influence IBD activity and could point to new...
Surgery for IBD has become less common since modern biologic therapies, but a noticeable number of patients—especially with Crohn’s disease and poor nutrition—still progress to operations. Understanding who remains at...
Identifying simple features at diagnosis that predict a disabling 5‑year course could help patients and clinicians plan monitoring and treatment intensity earlier after Crohn’s diagnosis.
The study identifies macrophage-derived microvesicles as modulators of intestinal barrier function and ER stress in ulcerative colitis models, suggesting a new mechanism that could be relevant to mucosal healing...
Based on the title and source metadata, this appears to be a case report related to Ulcerative colitis, Inflammatory bowel disease, and Complications. The original article is from Cureus.
People with IBD may face higher-than-expected rates of hypertensive disorders in pregnancy; identifying predictors could help target monitoring and preventive strategies. The study suggests prior HDP and gestational...
Mesalamine can rarely cause myocarditis, creating a challenge for ongoing UC treatment. This report shows upadacitinib was used successfully as an alternative when biologics were considered higher cardiac risk and...
Environmental exposures from agricultural chemicals may affect the gut microbiome and intestinal inflammation, which could be one factor influencing IBD risk or flares. Understanding these links could point to preventive...
Researchers are studying necroptosis — a form of inflammatory cell death — because it appears to contribute to inflammatory bowel disease and other inflammatory conditions. Understanding the molecular steps could point...
People with PsD or IBD — or both — may develop the other condition years later, and the order of diagnoses appears linked to timing of the second disease and to differences in mortality for some groups. That could affect...
People with both IBD and another immune-mediated disease (psoriatic disease) had more hospital admissions and higher inpatient costs over ten years in this population.
Severe ulcerative colitis can be linked to rare cardiac rhythm disturbances; recognizing bradycardia during flares may prompt appropriate evaluation and monitoring. The case signals clinicians to consider cardiac causes...
Cure8 could only read part of this source from PubMed Central, so this card uses cautious topic tags instead of a full summary. It is tagged for Ulcerative colitis, Inflammatory bowel disease, and Research and clinical...
Perianal fistulas in Crohn’s disease are hard to treat and preserving continence is important. Long-term data suggesting laser ablation can achieve sustained healing in some patients are relevant for treatment decisions.
The study highlights factors linked to needing another operation after ileocecal resection for Crohn’s disease and suggests postoperative biologic therapy may lower long-term reoperation risk. That directly affects...
The study provides real-world effectiveness and safety data for risankizumab in a largely difficult-to-treat Crohn's population, showing about half achieved corticosteroid-free clinical remission at 24 weeks —...
This helps people with IBD and their care teams make delivery plans: if perianal disease is not active, having IBD alone was not linked to higher perineal injury risk in first-time vaginal births in this study.
Adding partial enteral nutrition to ustekinumab was associated with better clinical, endoscopic, radiologic, and nutritional outcomes at 52 weeks in this multicentre real-world cohort of Crohn’s disease patients. This...
This study suggests that genetic risk for Crohn disease and ulcerative colitis may causally increase the risk of developing ankylosing spondylitis, an inflammatory joint condition that commonly co-occurs with IBD.
If true, a causal link between IBD and pancreatitis could help explain why people with Crohn’s disease or ulcerative colitis sometimes develop acute or chronic pancreatitis and could guide research into shared biological...
Frailty is linked to worse outcomes in older people with IBD, so knowing how common it is—and which patients are at higher risk—can influence monitoring and treatment planning.
Patients with IBD who are frail appear to have a substantially higher risk of infections while on biologic therapies compared with fit patients. Recognizing frailty before and during treatment could improve risk...
People with IBD sometimes are excluded from or uncertain about immune checkpoint inhibitor cancer trials because of concerns about triggering autoimmune flares. This trial explicitly studies safety and disease impact in...
Intestinal fibrosis is a serious complication of long-standing ulcerative colitis. Identifying NET-related biomarkers (IL1RN, MUC1, SERPINA1) could help researchers develop better diagnostic tools or treatments targeting...
HLH is a rare but life‑threatening complication that can be triggered by herpesvirus infection in immunosuppressed IBD patients. Awareness may speed diagnosis and treatment for symptomatic patients on therapies like JAK...
CDI occurs more often in hospitalized people with IBD than in those without IBD. Understanding which patients are at higher risk for death or complications can help hospitals prioritize early testing and management to...
Extraintestinal manifestations (EIMs) can significantly affect people with IBD and may require multidisciplinary care. Knowing how often EIMs are documented and which patients are more likely to have them helps...
Researchers found distinct microbial and host molecular features in the appendices of children with IBD, which could help explain local immune activation and guide future studies of disease mechanisms or biomarkers.
Low zinc levels were linked with higher one-year relapse risk in UC patients in remission; knowing zinc status might add prognostic information beyond standard labs.
Older adults with ulcerative colitis can rarely develop large-vessel giant cell arteritis as an extraintestinal complication.
Lung involvement is an underrecognized extraintestinal complication in IBD and can reflect disease activity, altered gut–lung immune signaling, or medication toxicity — distinguishing the cause is important for...
CDI is a common and important complication in people with IBD; which antibiotic is used can affect recurrence risk and subsequent need for surgery. This review pools available studies and suggests vancomycin may reduce...
HLH is a rare but serious complication in immunosuppressed IBD patients; visceral leishmaniasis can trigger HLH and may be overlooked outside endemic areas. Early bone marrow assessment can speed diagnosis and treatment.
