Article Archive

Page 76 of 100 · 4789 patient-friendly summaries

Letter to the Editor to "Volatomics-based biomarkers for non-invasive diagnosis and monitoring of inflammatory bowel disease".
Journal of gastroenterology

Letter to the Editor to "Volatomics-based biomarkers for non-invasive diagnosis and monitoring of inflammatory bowel disease".

Cure8 found this source from Journal of gastroenterology, but the page could not be read reliably yet. It is tagged for Inflammatory bowel disease, Biomarkers, and Research and clinical trials. Open the original article...

Read Summary
Fusobacterium nucleatum-derived succinic acid aggravates colitis by triggering macrophage pro-inflammatory phenotypic transformation via SUCNR1/NF-κB axis.
Gut microbes

Fusobacterium nucleatum-derived succinic acid aggravates colitis by triggering macrophage pro-inflammatory phenotypic transformation via SUCNR1/NF-κB axis.

The paper identifies a specific bacterial metabolite-receptor pathway (succinic acid → SUCNR1 → NF-κB) by which Fusobacterium nucleatum may worsen intestinal inflammation, suggesting new targets for IBD research and...

Read Summary
Revisiting the Oral–Gut Axis: Microbial Symbiosis, Dysbiosis, and Bidirectional Links Between Periodontitis and Inflammatory Bowel Disease
Microorganisms

Revisiting the Oral–Gut Axis: Microbial Symbiosis, Dysbiosis, and Bidirectional Links Between Periodontitis and Inflammatory Bowel Disease

The oral microbiome can influence gut microbes and inflammation; understanding this link could lead to new diagnostic markers (saliva) or combined dental–gastroenterology care approaches relevant to people with IBD.

Read Summary
‘We need to highlight as a community that these are avoidable’: exploring clinician perspectives on healthcare access and avoidable admissions in inflammatory bowel disease
Frontline Gastroenterology

‘We need to highlight as a community that these are avoidable’: exploring clinician perspectives on healthcare access and avoidable admissions in inflammatory bowel disease

Avoidable unplanned hospital admissions are common and costly for people with IBD. This study suggests many such admissions stem from healthcare access and service delivery problems—not just disease severity—so system...

Read Summary
Fluorescent Probes for Intestinal Diseases: Design Strategies, Imaging Mechanisms and Biomedical Applications
Advanced Functional Materials

Fluorescent Probes for Intestinal Diseases: Design Strategies, Imaging Mechanisms and Biomedical Applications

New or improved fluorescent probes could enable more sensitive, noninvasive imaging of biochemical changes in the gut, which may aid research, earlier diagnosis, or monitoring of IBD and colorectal cancer.

Read Summary
Atopic Dermatitis and Risk of Inflammatory Bowel Disease in Children: A Systematic Review and Meta-Analysis
Cureus

Atopic Dermatitis and Risk of Inflammatory Bowel Disease in Children: A Systematic Review and Meta-Analysis

This review found that children with atopic dermatitis have a modestly higher risk of later developing IBD (both Crohn’s disease and ulcerative colitis). Awareness of this association may help clinicians and families...

Read Summary
Severe Pancolitis Presenting with Sacroiliitis: A Case Highlighting the Gut-Joint Axis in Ulcerative Colitis
Case Reports in Gastroenterology

Severe Pancolitis Presenting with Sacroiliitis: A Case Highlighting the Gut-Joint Axis in Ulcerative Colitis

This case shows that ulcerative colitis can first appear with inflammatory back pain (sacroiliitis) rather than bowel symptoms; recognizing this link can lead to earlier diagnosis and treatment that may help both gut and...

Read Summary
Endoplasmic reticulum stress in the logic of ulcerative colitis development
Experimental and Clinical Gastroenterology

Endoplasmic reticulum stress in the logic of ulcerative colitis development

ER stress in intestinal epithelial cells is proposed as a key molecular mechanism in UC development; targeting ER pathways (notably IRE1β) could eventually lead to new treatments that strengthen the gut barrier and...

Read Summary
Bowel Urgency in Ulcerative Colitis Is Associated With Clinical Endpoints, Health-Related Quality of Life, and Biomarkers: Data From the Etrasimod ELEVATE UC 52 Trial
Crohn's & Colitis 360

Bowel Urgency in Ulcerative Colitis Is Associated With Clinical Endpoints, Health-Related Quality of Life, and Biomarkers: Data From the Etrasimod ELEVATE UC 52 Trial

Bowel urgency is a common, disruptive UC symptom; this trial analysis shows urgency improvements with etrasimod track with clinical remission, endoscopic improvement, better quality of life, and lower inflammatory...

Read Summary
Demographic Analysis of Patients With Ulcerative Colitis Undergoing Restorative Proctocolectomy With Ileal Pouch-Anal Anastomosis: A Single-Center Retrospective Study.
Cureus

Demographic Analysis of Patients With Ulcerative Colitis Undergoing Restorative Proctocolectomy With Ileal Pouch-Anal Anastomosis: A Single-Center Retrospective Study.

Pouch surgery is a key restorative option for people with ulcerative colitis, but pouchitis, chronic antibiotic-refractory pouchitis (CARP), pouch failure, and occasional reclassification to Crohn’s disease can cause...

Read Summary
Causal Insights Into Crohn's Disease: The Role of Oxidative Stress and Genetic Variants.
Journal of cellular and molecular medicine

Causal Insights Into Crohn's Disease: The Role of Oxidative Stress and Genetic Variants.

People with Crohn’s may be interested because the study links oxidative stress and specific genes to disease activity, which could inform future biomarkers or treatments. It helps explain biological pathways behind...

Read Summary
Clinical efficacy analysis of acupuncture combined with anti-tumor necrosis factor treatment for spleen and kidney yang deficiency type ulcerative colitis.
Frontiers in medicine

Clinical efficacy analysis of acupuncture combined with anti-tumor necrosis factor treatment for spleen and kidney yang deficiency type ulcerative colitis.

The report suggests adding acupuncture to anti-TNF therapy may improve short-term symptom control and mucosal healing and reduce early colectomy risk for a TCM-defined subgroup of ulcerative colitis patients, which could...

Read Summary
Hepatic and splenic tuberculosis following infliximab therapy for refractory ulcerative colitis: a case report and literature review
BMC Gastroenterology

Hepatic and splenic tuberculosis following infliximab therapy for refractory ulcerative colitis: a case report and literature review

Extrapulmonary TB can be triggered or revealed during immunosuppressive biologic therapy and may mimic other causes of liver injury; early recognition and TB-specific testing are important for timely treatment and to...

Read Summary
Association of interleukin-38 and its polymorphism (rs7599662) with ulcerative colitis
The Egyptian Journal of Internal Medicine

Association of interleukin-38 and its polymorphism (rs7599662) with ulcerative colitis

IL-38 and a genetic variant (rs7599662) were linked to ulcerative colitis in this study, suggesting a possible new biomarker or therapeutic target. If validated, this could help researchers better understand UC...

Read Summary
Study of Oral Upadacitinib to Assess Change in Disease Activity in Adult Participants With Ulcerative Colitis
ClinicalTrials.gov

Study of Oral Upadacitinib to Assess Change in Disease Activity in Adult Participants With Ulcerative Colitis

This study will collect real-world data on adults with moderate-to-severe ulcerative colitis who start upadacitinib, tracking symptom remission and imaging response over one to two years — information that can help...

Read Summary
A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis
ClinicalTrials.gov

A Study of Long-acting Antibodies Alone and in Combinations for Moderate to Severe Ulcerative Colitis

This trial tests several investigational long-acting antibody treatments (as monotherapies and combinations) for adults with moderate to severe ulcerative colitis using histologic and clinical remission endpoints —...

Read Summary
Linker Engineering toward NIR-II Metal-Organic Framework with Maximal Emission beyond 1000 nm for Inflammatory Bowel Disease Imaging.
Journal of the American Chemical Society

Linker Engineering toward NIR-II Metal-Organic Framework with Maximal Emission beyond 1000 nm for Inflammatory Bowel Disease Imaging.

A new NIR-II-emitting MOF probe could enable deeper, higher-contrast fluorescence imaging of inflamed gut tissue and might be developed as a targeted delivery/imaging agent relevant to IBD research and future...

Read Summary
Partial enteral nutrition combined with an exclusion diet promotes a healthy gut microbiome in patients with mild to moderately active ulcerative colitis: a quasi-experimental study.
Crohn's & colitis 360

Partial enteral nutrition combined with an exclusion diet promotes a healthy gut microbiome in patients with mild to moderately active ulcerative colitis: a quasi-experimental study.

Dietary strategies that change the gut microbiome are of interest because they might modify inflammation without drugs. This study suggests PEN+ED can shift the microbiome toward a healthier profile in UC, though...

Read Summary
Time trends in strategies for postoperative Crohn's disease management and long-term surgical recurrence: ENEIDA registry data.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Time trends in strategies for postoperative Crohn's disease management and long-term surgical recurrence: ENEIDA registry data.

The findings suggest that over three decades more patients receive medical prevention after ileocolic resection — including thiopurines and biologics — and that rates of needing a second surgery have fallen. This matters...

Read Summary
Utility of endoscopic ileocecal valve-plasty for Crohn's disease: a propensity-matched retrospective study.
Surgical endoscopy

Utility of endoscopic ileocecal valve-plasty for Crohn's disease: a propensity-matched retrospective study.

People with Crohn’s disease and fibrotic ileocecal valve strictures sometimes face surgery when endoscopic access is blocked by polypoid tissue. A new endoscopic approach (ICVP) aims to remove obstructing tissue so...

Read Summary
Long-term treatment trajectories and surgical outcomes in Chinese patients with ulcerative colitis
World Journal of Gastroenterology

Long-term treatment trajectories and surgical outcomes in Chinese patients with ulcerative colitis

Shows real-world long-term outcomes in a large Chinese UC cohort and highlights that baseline disease activity predicts need for escalation and colectomy risk; points to opportunities to improve treat-to-target care.

Read Summary
Computational toxicology prioritization of CYP3A4 and DPP7 as candidate triclosan-relevant molecular targets in ulcerative colitis
Toxicology Mechanisms and Methods

Computational toxicology prioritization of CYP3A4 and DPP7 as candidate triclosan-relevant molecular targets in ulcerative colitis

Based on the title and source metadata, this appears to be a basic science related to Ulcerative colitis, Inflammatory bowel disease, and Research and clinical trials. The original article is from Toxicology Mechanisms...

Read Summary
Impact of Inflammatory Activity on Anorectal Function in Patients With Ulcerative Colitis: A Prospective Study
Alimentary Pharmacology & Therapeutics

Impact of Inflammatory Activity on Anorectal Function in Patients With Ulcerative Colitis: A Prospective Study

This study links active UC inflammation to measurable anorectal dysfunction (greater rectal sensitivity, lower compliance/capacity) that helps explain common symptoms such as urgency and fecal incontinence. Some...

Read Summary
Lapatinib mitigates acetic acid-induced ulcerative colitis and hepatic damage in rats
Naunyn-Schmiedeberg's Archives of Pharmacology

Lapatinib mitigates acetic acid-induced ulcerative colitis and hepatic damage in rats

This study suggests the cancer drug lapatinib reduced colon damage and liver changes in a rat model of chemical colitis, which could point to new research directions for IBD treatments or gut–liver injury mechanisms.

Read Summary
Extracellular vesicles produced by Malassezia commensal yeasts.
Extracellular vesicles and circulating nucleic acids

Extracellular vesicles produced by Malassezia commensal yeasts.

Malassezia extracellular vesicles can modulate immune and microbial interactions; if similar mechanisms affect the gut, they could be relevant to inflammatory bowel disease and Crohn’s disease, though current evidence is...

Read Summary
Presentation and Clinical Outcomes of Inflammatory Bowel Disease in Children and Adolescents at a Tertiary Care Center in Lebanon.
Journal of clinical medicine

Presentation and Clinical Outcomes of Inflammatory Bowel Disease in Children and Adolescents at a Tertiary Care Center in Lebanon.

This study describes how IBD presents and early outcomes in children at a tertiary center, noting high rates of inflammation, nutritional problems, and early flares. Findings may help families and clinicians understand...

Read Summary
Efficacy and Safety of Oral Prednisolone and Budesonide MMX for Outpatient Induction Therapy in Active Ulcerative Colitis: A Multicenter Retrospective Cohort Study.
Journal of clinical medicine

Efficacy and Safety of Oral Prednisolone and Budesonide MMX for Outpatient Induction Therapy in Active Ulcerative Colitis: A Multicenter Retrospective Cohort Study.

The study compares two oral steroid therapies used to induce remission in outpatient ulcerative colitis and reports similar short-term efficacy but different safety profiles — information that can inform treatment...

Read Summary
Rescue Vedolizumab Therapy for a Rare Case of Complicated Severe Ulcerative Colitis: A Case Report and Literature Review.
Journal of clinical medicine

Rescue Vedolizumab Therapy for a Rare Case of Complicated Severe Ulcerative Colitis: A Case Report and Literature Review.

This case report describes successful use of vedolizumab to treat severe UC in a patient who also had PSC and SLE — a rare and complex combination. Patients and clinicians may find it relevant when considering biologic...

Read Summary
Microplastics, Gut Dysbiosis, and Inflammatory Pathways in Ulcerative Colitis.
Journal of inflammation research

Microplastics, Gut Dysbiosis, and Inflammatory Pathways in Ulcerative Colitis.

If environmental microplastics contribute to gut dysbiosis and mucosal inflammation, this could help explain environmental triggers of ulcerative colitis and point toward prevention or microbiome-targeted interventions.

Read Summary
Gegen Qinlian Decoction Mitigates DSS-Induced Acute Colitis and Reinstates Gut Barrier Function in Mice, Correlating with Suppressed IL-33/ST2 Signaling.
Journal of inflammation research

Gegen Qinlian Decoction Mitigates DSS-Induced Acute Colitis and Reinstates Gut Barrier Function in Mice, Correlating with Suppressed IL-33/ST2 Signaling.

Researchers used a standard mouse colitis model to show a traditional herbal formula reduced inflammation and improved gut barrier markers, implicating the IL-33/ST2 immune pathway. This could guide future preclinical...

Read Summary
Current and novel biomarkers for predicting and assessing therapeutic response in inflammatory bowel disease: a systematic review.
Therapeutic advances in gastroenterology

Current and novel biomarkers for predicting and assessing therapeutic response in inflammatory bowel disease: a systematic review.

People with IBD and their clinicians want ways to predict which advanced therapy will work best. This review summarizes current evidence and shows that, despite many studies, no biomarker is reliably ready for routine...

Read Summary
Inflammatory Bowel Disease and Its Unique Impact on Body Image: A Qualitative Exploration.
Journal of clinical psychology

Inflammatory Bowel Disease and Its Unique Impact on Body Image: A Qualitative Exploration.

Body-image concerns in IBD are linked with poorer mental health, eating behaviours, and overall quality of life. Understanding these experiences can help clinicians and support services better address emotional and...

Read Summary
Impact of pediatric vs. adult diagnosed IBD on achievement of health care autonomy in emerging adults: a cross-sectional study
Crohn s & Colitis 360

Impact of pediatric vs. adult diagnosed IBD on achievement of health care autonomy in emerging adults: a cross-sectional study

Emerging adults with IBD face distinct challenges managing care. The study shows people diagnosed as children may know about their disease but still need help with practical self-management tasks — a gap that can affect...

Read Summary