Nutrition, food, supplements, exercise, sleep, stress, and lifestyle research for Crohn's disease and IBD.
Page 15 of 24 · 1124 articles
This review pools available human and animal studies on sodium butyrate for ulcerative colitis and highlights promising signals—especially for oral microencapsulated formulations—while noting that clinical evidence is...
The study explores a novel, combined nanozyme + microbiome-derived vesicle approach aimed at reducing oxidative stress and modulating inflammation in IBD — mechanisms that are relevant to disease pathways and future...
People with UC often seek dietary strategies to help manage inflammation; this study uses AI and docking to prioritize polyphenols and foods for future testing, which could guide research and eventually inform dietary...
This review organizes and grades causal evidence linking individual gut bacteria, their metabolites, and host pathways in IBD—helping researchers and clinicians see which microbe–metabolite mechanisms are best supported...
Nutrition affects disease course, symptom burden, complications, and quality of life in IBD. A phenotype-based framework could help clinicians and patients personalize dietary and nutrition interventions more...
If true, the study suggests that long-term air pollution exposure may raise the risk of developing IBD and that greater adherence to a plant-based diet could be linked with a lower pollution-related risk. That may be...
Researchers are exploring non-drug enzyme-like catalysts to reduce oxidative stress in IBD—this study reports a new artificial antioxidase that helped reduce inflammation in cell and animal models, which could point to...
This project seeks to clarify how gut microbes and diet drive CD4+ T cell responses—mechanisms that are central to intestinal tolerance and to diseases like IBD. A better map of TCR–antigen pairs and how tolerance breaks...
Researchers are exploring a way to deliver biologic drugs directly in the gut using engineered B cells that become long-lived plasma cells. If successful, this could allow sustained, localized anti-inflammatory protein...
Researchers are studying whether everyday microplastic exposure could worsen gut barrier injury in IBD and contribute to inflammatory or mental-health effects linked by the gut–brain axis.
Noninvasive stool metabolite patterns could eventually help predict which people with Crohn’s disease are more likely to develop strictures or penetrating complications, and may offer markers of disease activity and...
ILD is a potentially serious extraintestinal complication that appears more often with ulcerative colitis than with Crohn’s disease in this cohort study. Patients with both IBD and ILD had higher healthcare use and...
This preclinical study links cod skin–derived collagen peptides to reduced colitis severity in mice through changes in the gut microbiota and suppression of the NLRP3 inflammasome — pathways that could be relevant to...
Researchers are exploring ways to produce anti-inflammatory proteins directly at inflamed gut sites; this study describes a nanomaterial system intended to protect plasmid drugs and supply oxygen to sustain local protein...
This study explores a multi-component traditional medicine that the authors report can reduce experimental colitis and modulate inflammatory signaling and the gut microbiome — findings that could guide future preclinical...
This study reports an early-stage nanoplatform that combines targeted colon delivery of an aminosalicylate prodrug with scavenging of proinflammatory cfDNA, a dual strategy that reduced colitis severity in mice and could...
This is relevant because a treatable infection (intestinal tuberculosis) can present like colorectal cancer or IBD and lead to emergency surgery. Recognizing it earlier could change management and avoid unnecessary...
This study examines whether patterns of body size from birth through adulthood add information about IBD risk beyond adult BMI and genetic susceptibility. Results suggest life-course size trajectories may be more related...
People with IBD face higher rates of anxiety, depression and other psychiatric disorders that often begin years before diagnosis and can persist long term. Recognizing and treating mental-health issues early can improve...
People with IBD are often interested in new, less toxic therapies that restore gut health. PEVs are an emerging microbiome-based approach that could one day offer targeted immune and barrier benefits without live...
This study describes a new clay-based nanotherapy that reduced inflammation and oxidative stress in a common mouse model of colitis, suggesting a potential local treatment approach that targets multiple disease...
Virtual care reduced long-distance travel for IBD patients in remote Ontario, which both improves access to specialty care and appears to meaningfully lower travel-related CO2 emissions. Patients and clinics interested...
First‑degree relatives of people with IBD may worry about their own risk and consider diet as a way to reduce that risk. The study suggests how beliefs about genetics and diet influence whether relatives make preventive...
The study presents a new edible nanoparticle that delivers resveratrol to the colon and improved disease markers in a mouse model of ulcerative colitis, which could inform future delivery strategies for plant-derived...
The review connects microbiome-targeted therapies (diet, probiotics, FMT, antibiotics, and newer approaches) to mechanisms relevant to IBD and systemic health, highlighting why these strategies are of interest to...
The paper describes a new immunometabolic mechanism that strengthened intestinal barrier function and reduced colitis in mice, suggesting a potential pathway to develop therapies that boost ILC3-driven IL-22 production...
The study investigates how specific gut bacterial strains can change colitis severity in experimental models — important because microbes are a focus of IBD research and potential therapies.
A structured ERP adapted for children could shorten hospital stays and improve recovery after pediatric GI surgery; this trial tested both clinical effectiveness and real-world implementation across many pediatric...
Dietary strategies like the Mediterranean diet and time-restricted feeding could be low-risk ways to influence gut microbiota, short-chain fatty acids, and inflammation in people with ulcerative colitis; this trial will...
The study suggests a Moringa-derived polysaccharide may reduce inflammation in a mouse model of ulcerative colitis by altering gut microbiota, metabolites, and inflammatory/antioxidant signaling — a potential preclinical...
This review links lactic acid bacteria ecology in engineered communities to potential applications in gut health and IBD research, which could guide future microbiome-based interventions.
Crohn's-like disease of the pouch is a meaningful complication after IPAA that can impair quality of life and risk pouch failure; knowing which drug classes show promise for specific pouch phenotypes can guide...
If you have PSC-IBD or care for someone who does, this study suggests the gut microbiota and its ability to make secondary bile acids may help drive inflammation and colorectal dysplasia risk.
Researchers are exploring natural compounds that may modulate gut microbes, barrier function, and immune signaling relevant to ulcerative colitis.
This pooled analysis compares multiple microbiota-directed therapies and suggests FMT, probiotics, and synbiotics may improve clinical remission in adults with IBD, with FMT also showing benefit for endoscopic remission....
This study suggests a new, non‑live (“postbiotic”) approach—extracellular vesicles from pasteurized Akkermansia muciniphila—may reduce inflammation and improve barrier function in an experimental colitis model, which...
Researchers and clinicians are exploring how fucose metabolism affects gut barrier function, immunity, and microbiota — processes central to IBD and colorectal cancer. If validated, fucosylation biomarkers or treatments...
This review outlines BEVs as a microbiome-derived, engineered nanotherapy concept that could influence gut barrier repair and immune regulation—areas directly relevant to managing IBD activity and treatment resistance.
Many people with Crohn’s disease have ongoing inflammation despite stable medication. If dietary personalization can reduce inflammation, it could offer a nonpharmacologic add-on to help bridge gaps without immediate...
This study describes a new plant-derived nanoparticle (EBDEVs) that reduced inflammation and improved colon health in a mouse model of ulcerative colitis and altered the gut microbiota — early evidence that may guide...
The study proposes a targeted oral delivery method that could help concentrate anti-inflammatory natural compounds at inflamed colon sites, potentially improving treatment effectiveness for ulcerative colitis while...
Antibiotics commonly used against anaerobes affected opportunistic IBD-associated strains and beneficial commensals differently in lab cultures; this could influence thinking about using broad‑spectrum antibiotics to...
Patients on anti-TNF biologics often seek safe ways to support gut microbial health. This trial tests a prebiotic supplement (2'-FL) for safety and whether it increases beneficial bacteria and butyrate in young people...
This work describes a novel engineered probiotic designed to survive the gastrointestinal tract and act specifically at inflamed colitis sites, which could lead to new targeted therapies for IBD if validated in humans.
Immigrants with IBD reported substantial barriers to care — language gaps, work-related limits on attending appointments, and cultural concerns — which can hinder disease management. Recognizing these issues can help...
The study suggests a combined probiotic-plus-nutrient approach may improve intestinal barrier integrity, reduce inflammation, and restore epithelial metabolism in an IBD model—areas not fully addressed by current...
Researchers tested a ginger-derived glucan that reduced inflammation and reshaped the gut microbiota in a mouse colitis model — a potential prebiotic approach that could inform future IBD therapies or dietary strategies.
PSC occurring with IBD changes cancer risk and surveillance needs: patients can have extensive but asymptomatic colitis and a higher colorectal and biliary cancer risk. The review outlines gaps in diagnosis, monitoring,...
