Nutrition, food, supplements, exercise, sleep, stress, and lifestyle research for Crohn's disease and IBD.
Page 16 of 24 · 1124 articles
The review links macrophage-driven repair mechanisms to chronic inflammation and fibrosis in autoimmune diseases, including IBD, and highlights experimental strategies that aim to promote resolution rather than suppress...
The microbiome is increasingly viewed as an influence on IBD development and persistence, and microbiome-directed therapies (like FMT and engineered bacteria) are an active area of research that could one day add to...
This study reports a new colon-targeted delivery system for unconjugated bilirubin that reduced inflammation and improved mucosal healing in a mouse model of ulcerative colitis; it could inform future drug-development...
Diet can change gut microbes and their metabolites; this trial tests whether a high-protein, high-fiber diet can lower a microbe-derived compound (H2S) thought to be relevant in UC. If effective, diet-based approaches...
The study examines real-world activity and sedentary patterns in people with Crohn’s disease compared with matched controls and highlights sitting-time differences that could be modified without formal exercise programs.
Depression is common in people with ulcerative colitis and affects quality of life and disease outcomes. Knowing research trends helps patients and clinicians see where evidence and care approaches are focused,...
The study shows a probiotic strain reduced inflammation and improved gut barrier and microbiome/metabolite profiles in a mouse colitis model, indicating a possible new avenue for UC therapies worth further research.
This study identifies a plant-derived compound that reduced inflammation and promoted intestinal healing in mouse models by modulating the Wnt/β-catenin pathway and ILC3-driven IL-22 production—pathways relevant to...
XOR is linked to oxidative stress, inflammation, drug (thiopurine) metabolism, microbiome interactions, and inflammation-associated colorectal cancer — all processes relevant to IBD pathogenesis and complications....
This review describes a novel, targeted microbiome approach (phage therapy) aimed at bacteria linked to Crohn’s disease. If effective and proven safe in trials, phage therapy could offer a more precise way to reduce...
Epigenetic control of intestinal epithelial cells can shape gut microbes and influence colitis severity; understanding SETD2’s role could point to new mechanistic targets for IBD research and microbiome-directed...
This profile shows how someone with Crohn’s disease can continue competitive athletic pursuits while managing the condition. It highlights common issues for people with IBD—remission, stress-related flares,...
Dietary patterns are being studied as therapies for pediatric IBD because they may help induce remission or improve disease control without drugs.
Diet-based therapies like CDED + PEN may help control Crohn’s symptoms and improve nutrition without adding medications. This study suggests some adults can maintain remission and gain nutritional benefits over a year...
This review examines a noninvasive neuromodulation strategy (ta‑VNS) that might modulate immune and gut‑barrier biomarkers in IBD and could become an adjunctive therapy if validated in trials. Patients and clinicians may...
EEN is being evaluated as a non‑pharmacologic induction therapy in adults with active and complicated Crohn’s disease; results could inform whether EEN helps induce remission, improve nutrition, and impact inflammation...
The study identifies a specific gut microbe and a bile-acid metabolite that reduced inflammation in a mouse colitis model and implicates STAT3/NF-κB pathways — a potential new avenue for microbiome-based therapeutics for...
Krill oil improved colitis signs and intestinal barrier markers in a mouse model and changed colon gene expression linked to cell adhesion—findings that may interest people tracking dietary or supplemental approaches for...
Older adults with UC face different risks and treatment trade-offs than younger patients — higher infection and cancer risks, medication toxicities, and challenges with diagnosis and colonoscopy. Understanding these...
The study links a common environmental pollutant (UV-328) to worsened experimental colitis and altered cholesterol metabolism, suggesting environmental exposures might influence IBD activity and could point to new...
This review suggests SSRIs and SNRIs may influence both brain and gut pathways relevant to symptom burden in IBD and DGBI — potentially improving mood, pain, motility, and aspects of inflammation. That could matter for...
The study identifies Gardenia-derived pectic polysaccharides that reduced inflammation and restored colon health in a mouse colitis model, suggesting a possible microbiome-mediated protective effect relevant to IBD...
The study explores a multi-herb formula that the authors report reduces inflammation and alters gut microbiota in a mouse model of ulcerative colitis, suggesting possible biological mechanisms worth further study.
People with IBD may have a higher-than-expected rate of biopsy-confirmed celiac disease in this Northern Indian cohort, and standard anti-tTG blood tests can be falsely positive in IBD. Confirmatory duodenal biopsy is...
This study suggests plant-derived exosome-like nanoparticles from a traditional herbal decoction may reduce inflammation, oxidative stress, and alter gut microbiota in a mouse model of colitis — an early preclinical step...
This study suggests erythritol — a common non-nutritive sweetener — may worsen experimental colitis and depression-like behavior in mice via microbiome and metabolic changes, raising questions about how ultra-processed...
This study suggests that in IBD (and other diseases) the gut microbiome may lose long-associated symbionts and shift toward larger-genome, metabolically flexible microbes—an evolutionary perspective that could help...
Patients with Crohn's reported more relapses and are more likely to see diet as a relapse trigger; nutritional therapy (including elemental diets) is used more often in Crohn's than UC in this Japanese sample. This...
Identifies genetic and immune-pathway differences that may explain why Behçet's disease shows more intestinal involvement in some populations—insight that could inform research into IBD-like gut inflammation and future...
This meta-analysis pools randomized trial data and finds that FMT increased both clinical and endoscopic remission in ulcerative colitis versus placebo, which could matter to patients and clinicians exploring...
Environmental exposures from agricultural chemicals may affect the gut microbiome and intestinal inflammation, which could be one factor influencing IBD risk or flares. Understanding these links could point to preventive...
The article connects everyday activities like gardening and spending time in nature to microbial exposure that some researchers link to lower rates of autoimmune and inflammatory conditions, including Crohn’s disease and...
Vitamin D may support intestinal barrier integrity and immune regulation—pathways central to mucosal healing and disease control in IBD. Understanding the evidence helps patients and clinicians consider vitamin D as a...
Researchers are developing a novel drug-discovery approach to degrade GATA3, a protein that drives Th2 inflammation in ulcerative colitis. New therapies that more directly target immune drivers could eventually help...
Frequent, accurate assessment of bowel inflammation and fibrosis is critical for Crohn's disease care. Ultrasound is safe, accessible, and could provide a low-cost biomarker to monitor disease activity, fibrosis, and...
Oral problems and periodontal disease can affect quality of life and may be more common in people with IBD; this study suggests many patients report oral health needs and gaps in dental care.
The paper presents integrated preclinical evidence that a multi-herb formula (GQG) can reduce inflammation and alter gut microbiota and metabolites in a mouse model of ulcerative colitis, highlighting possible mechanisms...
People with Crohn’s may be interested because the review discusses novel natural compounds that target oxidative stress and inflammation — pathways involved in disease activity — and highlights formulation challenges...
The oral microbiome in children with Crohn's disease appears to reflect disease severity and changes with treatment, suggesting a potential noninvasive biomarker for monitoring response to nutritional therapies like CDED...
IBD and other lower-GI disorders may benefit from oral hydrogel platforms that improve local drug delivery while deliberately engaging the gut microbiota. Understanding this research direction helps patients and...
Adding partial enteral nutrition to ustekinumab was associated with better clinical, endoscopic, radiologic, and nutritional outcomes at 52 weeks in this multicentre real-world cohort of Crohn’s disease patients. This...
People with IBD may see growing interest in nonpharmacologic approaches like acupuncture; this review summarizes preclinical evidence suggesting acupuncture can reduce inflammation and support intestinal barrier proteins...
This preclinical study suggests cigarette smoke alters gut microbes and metabolites in ways that can either protect or worsen colitis depending on the model; it identifies 4-HBA as a metabolite that reduced inflammation...
Adolescents and young adults with IBD commonly face pain and may receive opioids; a digital tool designed with patient and clinician input could help reduce opioid-related risks and improve coordination of pain care.
Market shifts — including more biosimilars, expanding biologic and small-molecule options, and wider online pharmacy access — can affect how quickly and affordably new Crohn’s treatments reach patients. Patients on...
The study suggests a common food (edible bird's nest) may influence gut inflammation, barrier function, and microbiota in ways that could be relevant to IBD research and future dietary interventions.
People with IBD commonly have extraintestinal symptoms (mood disorders, fatigue, pain, nutritional problems) that affect quality of life and need proactive identification and management in primary care.
This trial tests whether pomegranate juice can lower fecal calprotectin, a commonly used marker of intestinal inflammation, in people with IBD in remission. If effective, such a dietary approach could be of interest to...
