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Page 6 of 9 · 399 articles

Molecular mechanisms of allergic type 2 immunity in the pathogenesis of Crohn's disease: From epithelial alarmins to IgE signaling.
Cellular and molecular biology (Noisy-le-Grand, France)

Molecular mechanisms of allergic type 2 immunity in the pathogenesis of Crohn's disease: From epithelial alarmins to IgE signaling.

The review suggests that allergic-type (type 2) immune pathways may play a meaningful role in some people with Crohn's disease, which could point to new treatment options that target IgE, Th2 cytokines, epithelial...

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Erythritol Exacerbates DSS-Induced Colitis and Influences Behavioral Responses in Mice Through Gut Microbiota and Metabolic Alterations
Microorganisms

Erythritol Exacerbates DSS-Induced Colitis and Influences Behavioral Responses in Mice Through Gut Microbiota and Metabolic Alterations

This study suggests erythritol — a common non-nutritive sweetener — may worsen experimental colitis and depression-like behavior in mice via microbiome and metabolic changes, raising questions about how ultra-processed...

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Features and Outcomes of Inflammatory Bowel Disease among Filipino Children in a Tertiary Hospital: An Eleven-year Review.
Acta medica Philippina

Features and Outcomes of Inflammatory Bowel Disease among Filipino Children in a Tertiary Hospital: An Eleven-year Review.

This study provides region-specific pediatric IBD data from the Philippines, highlighting prevalence of very-early-onset disease, perianal involvement in Crohn's, and factors (diagnostic delay, wasting, pancolitis)...

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Nutrition management and self-perceived relapse triggers in patients with inflammatory bowel disease: results from the 3R web-based survey.
Crohn's & colitis 360

Nutrition management and self-perceived relapse triggers in patients with inflammatory bowel disease: results from the 3R web-based survey.

Patients with Crohn's reported more relapses and are more likely to see diet as a relapse trigger; nutritional therapy (including elemental diets) is used more often in Crohn's than UC in this Japanese sample. This...

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Performance of the 2025 ASAS-Spartan Revised Classification Criteria for Axial Spondyloarthritis in a Canadian Multicenter Inception Cohort with Psoriasis, Uveitis, or Colitis Presenting with Undiagnosed Back Pain

The criteria were tested specifically in patients with psoriasis, uveitis, or IBD presenting with chronic back pain—groups at higher risk of axSpA—so results inform how well the new criteria perform in these real‑world...

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Screening Tools for Spondyloarthropathies Among Patients with Inflammatory Bowel Disease: A Scoping Review

SpA is a frequent but underrecognized extraintestinal manifestation in people with IBD; validated screening tools can help identify patients who need rheumatology evaluation. Earlier detection may address joint symptoms...

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An Observational Prospective Long-term Exposure Registry of Adult Patients With Moderate-to-Severe Ulcerative Colitis
ClinicalTrials.gov

An Observational Prospective Long-term Exposure Registry of Adult Patients With Moderate-to-Severe Ulcerative Colitis

Long-term safety data on biologics and thiopurines are important for people with ulcerative colitis because they help patients and clinicians weigh risks (including malignancies and pregnancy-related outcomes) when...

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Disability among Palestinian patients with inflammatory bowel disease: evaluation using the IBD Disk and identification of associated factors.
Crohn's & colitis 360

Disability among Palestinian patients with inflammatory bowel disease: evaluation using the IBD Disk and identification of associated factors.

Disability related to IBD affects daily functioning and quality of life; identifying factors linked with higher or lower disability (vitamin D status, azathioprine use, smoking) can help patients and clinicians consider...

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Psychosocial Experience, Impacts and Management of Fatigue in Young People With Inflammatory Bowel Disease—A Systematic Review
JCC Plus

Psychosocial Experience, Impacts and Management of Fatigue in Young People With Inflammatory Bowel Disease—A Systematic Review

Fatigue is a common, impactful symptom in pediatric and young-adult IBD but is poorly defined and measured, limiting the ability to design age-appropriate supports. This review highlights gaps that affect patients' daily...

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H7F ameliorates DSS-induced colitis through restoration of intestinal barrier function and inhibition of IL-17/NF-κb signaling.
Frontiers in pharmacology

H7F ameliorates DSS-induced colitis through restoration of intestinal barrier function and inhibition of IL-17/NF-κb signaling.

The study suggests a herbal formula (H7F) may protect intestinal barrier function, modulate the gut microbiome, and suppress IL-17/NF-κB inflammation in a mouse colitis model—mechanisms relevant to IBD pathophysiology.

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Associations between multidimensional sleep health and inflammatory bowel disease onset and activity: A systematic review of the RU-SATED framework
World Journal of Psychiatry

Associations between multidimensional sleep health and inflammatory bowel disease onset and activity: A systematic review of the RU-SATED framework

Sleep disturbance is common in IBD and may relate to disease risk and flares. Understanding which sleep problems are linked to onset or activity could point to new ways to support people with IBD.

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Exploratory Risk Patterns of Steroid Dependency in Ulcerative Colitis: A Multicenter Pilot Study Combining Logistic Regression and Self-Organizing Map Analysis.
Inflammatory intestinal diseases

Exploratory Risk Patterns of Steroid Dependency in Ulcerative Colitis: A Multicenter Pilot Study Combining Logistic Regression and Self-Organizing Map Analysis.

Steroid dependency affects many people with ulcerative colitis and can change long-term treatment plans. This study explores clinical factors and uses an AI clustering method to visualize different risk patterns, which...

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Persistent disease burden despite advanced therapies in inflammatory bowel disease: a real-world patient-reported survey from Greece.
Frontiers in immunology

Persistent disease burden despite advanced therapies in inflammatory bowel disease: a real-world patient-reported survey from Greece.

Many people with IBD still experience active disease, poor quality of life, work impairment, and depression even while on advanced therapies — highlighting gaps in how we measure and manage treatment success. Who this...

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Data-driven subphenotyping uncovers ulcerative colitis subtype with high risk for relapse in Japan: a prospective multicenter cohort study
The Lancet Regional Health - Western Pacific

Data-driven subphenotyping uncovers ulcerative colitis subtype with high risk for relapse in Japan: a prospective multicenter cohort study

The study suggests quality-of-life and patient-reported measures can reveal a subgroup of UC patients in clinical remission who nevertheless have higher relapse risk, which could help personalize monitoring and care.

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Fecal incontinence among patients with ulcerative colitis and relation with disease activity, and extent: A cross-sectional study.
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology

Fecal incontinence among patients with ulcerative colitis and relation with disease activity, and extent: A cross-sectional study.

Fecal incontinence is a distressing symptom that lowers quality of life and appears linked to active disease in UC. Knowing which patients are at higher risk can help clinicians focus assessment and symptom support.

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Serum immune profiling suggests overlap between IBD patients with joint complaints and patients with spondyloarthritis.
Frontiers in immunology

Serum immune profiling suggests overlap between IBD patients with joint complaints and patients with spondyloarthritis.

If you have IBD and joint symptoms, this study suggests your joint complaints may reflect measurable immune changes that partly overlap with spondyloarthritis, not just non-specific pain. That could mean joint symptoms...

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Systemic antibody responses against bacterial and viral antigens associate with fatigue in patients with inflammatory bowel disease.
iScience

Systemic antibody responses against bacterial and viral antigens associate with fatigue in patients with inflammatory bowel disease.

Fatigue is a common, disabling symptom in people with IBD with unclear causes. Finding reproducible immune or infectious signatures related to fatigue could point toward new research directions and, eventually, markers...

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Reduced fecal GP2 levels in ulcerative colitis associate with inflammatory activity and microbial composition.
Clinica chimica acta; international journal of clinical chemistry

Reduced fecal GP2 levels in ulcerative colitis associate with inflammatory activity and microbial composition.

If fecal GP2 reliably reflects UC activity and microbial changes, it could become a noninvasive marker to track inflammation or to study disease mechanisms that differ between UC and CD.

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Assessment of kinesiophobia in ulcerative colitis: a case-control study highlighting functional and psychological implications.
Revista da Associacao Medica Brasileira (1992)

Assessment of kinesiophobia in ulcerative colitis: a case-control study highlighting functional and psychological implications.

Fear of movement was more common and more severe in people with ulcerative colitis in this study. Addressing kinesiophobia could help increase physical activity and improve function and quality of life for people with...

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Symptom Management Experiences of People Living With Crohn's Disease Through a Journey Map: A Qualitative Study.
Journal of clinical nursing

Symptom Management Experiences of People Living With Crohn's Disease Through a Journey Map: A Qualitative Study.

A patient-centered journey map identifies changing symptom, psychological, and social needs at different stages of Crohn's disease. That can help clinicians and care teams target education, mental-health support, and...

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Anti-inflammatory efficacy of diosgenin in an oxazolone-induced model of ulcerative colitis in mice via suppression of Th2 pathways and pSTAT3 expression: A prospective study.
Science progress

Anti-inflammatory efficacy of diosgenin in an oxazolone-induced model of ulcerative colitis in mice via suppression of Th2 pathways and pSTAT3 expression: A prospective study.

A natural compound (diosgenin) reduced disease signs and inflammatory markers in a mouse model of ulcerative colitis, suggesting a possible anti-inflammatory mechanism that could inform future preclinical research.

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Disorders of Gut-Brain Interaction like symptoms in Children with Inflammatory Bowel Disease: A Multicenter Prospective Study from the Pediatric IBD Porto Group of the ESPGHAN.
The American journal of gastroenterology

Disorders of Gut-Brain Interaction like symptoms in Children with Inflammatory Bowel Disease: A Multicenter Prospective Study from the Pediatric IBD Porto Group of the ESPGHAN.

Children with IBD can have persistent gut–brain interaction symptoms even when inflammation is quiescent; these symptoms are linked with worse quality of life and higher anxiety. Recognizing DGBI-like symptoms may help...

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Artemisia rupestris Improves the Microbiota–Barrier Axis in DSS Colitis
International Journal of Molecular Sciences

Artemisia rupestris Improves the Microbiota–Barrier Axis in DSS Colitis

The study suggests Artemisia rupestris extract can reduce inflammation, repair the intestinal barrier, and shift the gut microbiota and metabolites in a mouse colitis model — pathways that are important in IBD. These...

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Synergistic synbiotic therapies for ulcerative colitis: mechanistic insights from multi-targeted pathways in animal models
Inflammopharmacology

Synergistic synbiotic therapies for ulcerative colitis: mechanistic insights from multi-targeted pathways in animal models

People with ulcerative colitis may be interested because synbiotic approaches aim to change the gut microbiome and intestinal barrier and therefore could become a future therapeutic option or adjunct. The paper...

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Meta-analysis: safety and efficacy of ustekinumab in pediatric inflammatory bowel disease patients with anti-TNF failure.
BMC gastroenterology

Meta-analysis: safety and efficacy of ustekinumab in pediatric inflammatory bowel disease patients with anti-TNF failure.

This review pools available pediatric data showing ustekinumab can induce and maintain remission after anti‑TNF failure, offering a treatment option for children with refractory IBD. Results are most robust for Crohn’s...

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Clinical characteristics and treatment patterns of older and younger patients with inflammatory bowel disease
World Journal of Gastroenterology

Clinical characteristics and treatment patterns of older and younger patients with inflammatory bowel disease

This study suggests that older-onset IBD is managed more conservatively and experiences fewer extraintestinal manifestations. Patients and clinicians should be aware that age can influence treatment choices and that...

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Association of serological markers with endoscopic mucosal healing and disease activity in patients with inflammatory bowel disease: a retrospective study
Frontiers in Immunology

Association of serological markers with endoscopic mucosal healing and disease activity in patients with inflammatory bowel disease: a retrospective study

Blood markers that correlate with endoscopic healing could help track inflammation noninvasively and may reduce the frequency of endoscopy if validated. For people with IBD, better blood-based tools could make monitoring...

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Hierarchical correlates of sexual dysfunction in inflammatory bowel disease: Psychological burden outweighs disease activity and sarcopenia.
Journal of psychosomatic research

Hierarchical correlates of sexual dysfunction in inflammatory bowel disease: Psychological burden outweighs disease activity and sarcopenia.

Sexual dysfunction is common in IBD and—according to this study—appears more strongly linked to psychological and demographic factors than to disease activity or muscle loss. Recognizing and treating mental-health issues...

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Lowering the C‐Reactive Protein ( CRP ) Threshold Improves Risk Stratification in Acute Ulcerative Colitis: A Propensity‐Matched Analysis
Alimentary Pharmacology & Therapeutics

Lowering the C‐Reactive Protein ( CRP ) Threshold Improves Risk Stratification in Acute Ulcerative Colitis: A Propensity‐Matched Analysis

Lowering the CRP cutoff could help hospitals identify hospitalized UC patients at higher risk of needing surgery who are currently classified as less severe. That may affect monitoring and treatment decisions during...

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Underevaluation of bowel urgency in clinical care: patient experiences and outcomes in ulcerative colitis: a retrospective cohort study
Inflammatory Bowel Diseases

Underevaluation of bowel urgency in clinical care: patient experiences and outcomes in ulcerative colitis: a retrospective cohort study

Bowel urgency is a common symptom that may predict higher risk of treatment escalation, hospitalization, or surgery in UC even when bleeding and stool frequency look controlled. Better assessment of urgency in clinic...

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Role of Fatty Acid Oxidation in Crohn's Disease and Ulcerative Colitis: Metabolomics Analysis and Experimental Evidence
PubMed Central

Role of Fatty Acid Oxidation in Crohn's Disease and Ulcerative Colitis: Metabolomics Analysis and Experimental Evidence

The study links depleted fatty acid oxidation metabolites—especially butyrate—to impaired regulatory T cell development in IBD, suggesting a metabolic pathway that may influence immune tolerance and disease activity.

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Diagnostic performance of fecal eosinophil-derived neurotoxin and lipocalin-2 in pediatric inflammatory bowel disease
BMC Gastroenterology

Diagnostic performance of fecal eosinophil-derived neurotoxin and lipocalin-2 in pediatric inflammatory bowel disease

Cure8 found this source from BMC Gastroenterology, but the page could not be read reliably yet. It is tagged for Inflammatory bowel disease and Tests and monitoring. Open the original article for the full details.

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